Biomedicines

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Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)
Biomedicines - Tập 10 Số 1 - Trang 118
Shima Tavakoli, Marta Kisiel, Thomas Biedermann, Agnes S. Klar
The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells...... hiện toàn bộ
Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology
Biomedicines - Tập 10 Số 5 - Trang 1012
Gabriela Elena Lupusoru, Ioana Ailincăi, Georgiana Frățilă, Oana Ungureanu, Andreea Andronesi, Mircea Lupușoru, Mihaela Banu, Ileana Adela Văcăroiu, Constantin Dina, I. Sinescu
Tumor lysis syndrome (TLS) is a common cause of acute kidney injury in patients with malignancies, and it is a frequent condition for which the nephrologist is consulted in the case of the hospitalized oncological patient. Recognizing the patients at risk of developing TLS is essential, and so is the prophylactic treatment. The initiation of treatment for TLS is a medical emergency that mu...... hiện toàn bộ
Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer
Biomedicines - Tập 6 Số 2 - Trang 40
Γεώργιος Μαρκόπουλος, Eugenia Roupakia, Maria Tokamani, Georgia Alabasi, Raphael Sandaltzopoulos, Kenneth B. Marcu, Evangelos Kolettas
The NF-κB family of transcription factors regulate the expression of genes encoding proteins and microRNAs (miRNA, miR) precursors that may either positively or negatively regulate a variety of biological processes such as cell cycle progression, cell survival, and cell differentiation. The NF-κB-miRNA transcriptional regulatory network has been implicated in the regulation of proinflammat...... hiện toàn bộ
The Thioredoxin System of Mammalian Cells and Its Modulators
Biomedicines - Tập 10 Số 7 - Trang 1757
Aseel Ali Hasan, Elena Kalinina, Victor V. Tatarskiy, Аlexander А. Shtil
Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS), which are produced as by-products of aerobic respiration. ROS play a significant role in cell homeostasis through redox signaling and are capable of eliciting damage to macromolecules. Multiple antioxidant defense...... hiện toàn bộ
IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications?
Biomedicines - Tập 9 Số 7 - Trang 799
Alişan Kayabölen, Ebru Yilmaz, Tugba Bagcı-Önder
Discovery of point mutations in the genes encoding isocitrate dehydrogenases (IDH) in gliomas about a decade ago has challenged our view of the role of metabolism in tumor progression and provided a new stratification strategy for malignant gliomas. IDH enzymes catalyze the conversion of isocitrate to alpha-ketoglutarate (α-KG), an intermediate in the citric acid cycle. Specific mutations ...... hiện toàn bộ
Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation
Biomedicines - Tập 8 Số 8 - Trang 246
Anders Askeland, Anne Borup, Ole Østergaard, Jesper V. Olsen, Sigrid Marie Lund, Gunna Christiansen, Søren Risom Kristensen, Niels H. H. Heegaard, Shona Pedersen
Extracellular vesicles (EVs) are small membrane-enclosed particles released by cells under various conditions specific to cells’ biological states. Hence, mass-spectrometry (MS) based proteome analysis of EVs in plasma has gained much attention as a method to discover novel protein biomarkers. MS analysis of EVs in plasma is challenging and EV isolation is usually necessary. Therefore, we ...... hiện toàn bộ
Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment
Biomedicines - Tập 9 Số 8 - Trang 940
Hye One Kim, Seok Young Kang, Jin Cheol Kim, Chun Wook Park, Bo Young Chung
Psoriasis is a chronic inflammatory systemic disease primarily affecting the skin, but which often involves considerable comorbidities as well. One-third of psoriasis cases start during childhood. In pediatric psoriasis, an association with several medical comorbidities is also indicated. Furthermore, because of its chronic nature and frequent relapses, psoriatic patients tend to require l...... hiện toàn bộ
Severe COVID-19 Illness and α1-Antitrypsin Deficiency: COVID-AATD Study
Biomedicines - Tập 11 Số 2 - Trang 516
Juan Luis Rodríguez Hermosa, Gianna Vargas Centanaro, María Estela González Castro, Marc Miravitlles, Lourdes Lázaro-Asegurado, Beatriz María Jiménez-Rodríguez, Rosanel Amaro Rodríguez, Rosaly Moreno Méndez, María Torres‐Durán, José María Hernández Pérez, Ana Navarro, Myriam Calle
Background: Epidemiologic studies have reported that the geographical distribution of the prevalence of allelic variants of serine protein inhibitor-A1 (SERPINA1) and severe cases of COVID-19 were similar. Methods: A multicenter, cross-sectional, observational study to evaluate the frequency of alpha-1 antitrypsin deficiency (AATD) in patients with COVID-19 and whether it was associated wi...... hiện toàn bộ
The Liquid Biopsy in the Management of Colorectal Cancer: An Overview
Biomedicines - Tập 8 Số 9 - Trang 308
Marco Vacante, Roberto Ciuni, Francesco Basile, Antonio Biondi
Currently, there is a crucial need for novel diagnostic and prognostic biomarkers with high specificity and sensitivity in patients with colorectal cancer. A “liquid biopsy” is characterized by the isolation of cancer-derived components, such as circulating tumor cells, circulating tumor DNA, microRNAs, long non-coding RNAs, and proteins, from peripheral blood or other body fluids and thei...... hiện toàn bộ
Zebrafish Larvae as a Behavioral Model in Neuropharmacology
Biomedicines - Tập 7 Số 1 - Trang 23
Ram Manohar Basnet, Daniela Zizioli, Somrat Taweedet, Dario Finazzi, Maurizio Memo
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark conditions, following the development of a swim bladder at 4 days post fertilization. This swimming behavior is increasingly employed in the screening of neuroactive drugs. The recent emergence of high-throughput techniques for the automatic tracking of zebrafish larvae has further allowed an objec...... hiện toàn bộ
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