Biomedicines
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Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)
Biomedicines - Tập 10 Số 1 - Trang 118
The immune system has a crucial role in skin wound healing and the application
of specific cell-laden immunomodulating biomaterials emerged as a possible
treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered
skin substitutes have the ability to activate immune pathways, even in the
absence of other immune-stimulating signals. In particular, mesenchymal stem
cells with th...
Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology
Biomedicines - Tập 10 Số 5 - Trang 1012
Tumor lysis syndrome (TLS) is a common cause of acute kidney injury in patients
with malignancies, and it is a frequent condition for which the nephrologist is
consulted in the case of the hospitalized oncological patient. Recognizing the
patients at risk of developing TLS is essential, and so is the prophylactic
treatment. The initiation of treatment for TLS is a medical emergency that must
be ad...
Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer
Biomedicines - Tập 6 Số 2 - Trang 40
The NF-κB family of transcription factors regulate the expression of genes
encoding proteins and microRNAs (miRNA, miR) precursors that may either
positively or negatively regulate a variety of biological processes such as cell
cycle progression, cell survival, and cell differentiation. The NF-κB-miRNA
transcriptional regulatory network has been implicated in the regulation of
proinflammatory, imm...
The Thioredoxin System of Mammalian Cells and Its Modulators
Biomedicines - Tập 10 Số 7 - Trang 1757
Oxidative stress involves the increased production and accumulation of free
radicals, peroxides, and other metabolites that are collectively termed reactive
oxygen species (ROS), which are produced as by-products of aerobic respiration.
ROS play a significant role in cell homeostasis through redox signaling and are
capable of eliciting damage to macromolecules. Multiple antioxidant defense
systems...
IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications?
Biomedicines - Tập 9 Số 7 - Trang 799
Discovery of point mutations in the genes encoding isocitrate dehydrogenases
(IDH) in gliomas about a decade ago has challenged our view of the role of
metabolism in tumor progression and provided a new stratification strategy for
malignant gliomas. IDH enzymes catalyze the conversion of isocitrate to
alpha-ketoglutarate (α-KG), an intermediate in the citric acid cycle. Specific
mutations in the g...
Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation
Biomedicines - Tập 8 Số 8 - Trang 246
Extracellular vesicles (EVs) are small membrane-enclosed particles released by
cells under various conditions specific to cells’ biological states. Hence,
mass-spectrometry (MS) based proteome analysis of EVs in plasma has gained much
attention as a method to discover novel protein biomarkers. MS analysis of EVs
in plasma is challenging and EV isolation is usually necessary. Therefore, we
compared...
Severe COVID-19 Illness and α1-Antitrypsin Deficiency: COVID-AATD Study
Biomedicines - Tập 11 Số 2 - Trang 516
Background: Epidemiologic studies have reported that the geographical
distribution of the prevalence of allelic variants of serine protein
inhibitor-A1 (SERPINA1) and severe cases of COVID-19 were similar. Methods: A
multicenter, cross-sectional, observational study to evaluate the frequency of
alpha-1 antitrypsin deficiency (AATD) in patients with COVID-19 and whether it
was associated with havin...
The Liquid Biopsy in the Management of Colorectal Cancer: An Overview
Biomedicines - Tập 8 Số 9 - Trang 308
Currently, there is a crucial need for novel diagnostic and prognostic
biomarkers with high specificity and sensitivity in patients with colorectal
cancer. A “liquid biopsy” is characterized by the isolation of cancer-derived
components, such as circulating tumor cells, circulating tumor DNA, microRNAs,
long non-coding RNAs, and proteins, from peripheral blood or other body fluids
and their genomi...
Zebrafish Larvae as a Behavioral Model in Neuropharmacology
Biomedicines - Tập 7 Số 1 - Trang 23
Zebrafish larvae show a clear and distinct pattern of swimming in response to
light and dark conditions, following the development of a swim bladder at 4 days
post fertilization. This swimming behavior is increasingly employed in the
screening of neuroactive drugs. The recent emergence of high-throughput
techniques for the automatic tracking of zebrafish larvae has further allowed an
objective and...
β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis
Biomedicines - Tập 10 Số 8 - Trang 1950
The sympathetic nervous system (SNS) has either a pro-inflammatory or
anti-inflammatory effect, depending on the stage of arthritis. In the past,
treatment of arthritic B cells with a β2-adrenergic receptor (β2-ADR) agonist
has been shown to attenuate arthritis. In this study, the expression and
signaling of β2-ADR in B cells during collagen-induced arthritis (CIA) were
investigated to provide an ...
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