Biomaterials Research

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Recent advances in stem cell therapeutics and tissue engineering strategies
Biomaterials Research - Tập 22 - Trang 1-8 - 2018
Seong Gyu Kwon, Yang Woo Kwon, Tae Wook Lee, Gyu Tae Park, Jae Ho Kim
Tissue regeneration includes delivering specific types of cells or cell products to injured tissues or organs for restoration of tissue and organ function. Stem cell therapy has drawn considerable attention since transplantation of stem cells can overcome the limitations of autologous transplantation of patient’s tissues; however, it is not perfect for treating diseases. To overcome the hurdles as...... hiện toàn bộ
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae
Biomaterials Research - Tập 26 - Trang 1-15 - 2022
Bojan Žunar, Taiga Ito, Christine Mosrin, Yoshiyuki Sugahara, Hélène Bénédetti, Régis Guégan, Béatrice Vallée
Engineered living materials (ELMs) combine living cells with non-living scaffolds to obtain life-like characteristics, such as biosensing, growth, and self-repair. Some ELMs can be 3D-printed and are called bioinks, and their scaffolds are mostly hydrogel-based. One such scaffold is polymer Pluronic F127, a liquid at 4 °C but a biocompatible hydrogel at room temperature. In such thermally-reversib...... hiện toàn bộ
Review of bone graft and bone substitutes with an emphasis on fracture surgeries
Biomaterials Research - Tập 23 - Trang 1-7 - 2019
Hoon-Sang Sohn, Jong-Keon Oh
Autogenous bone graft is the gold standard bone graft material. However, due to limitations of supply and morbidity associated with autograft harvest, various bone substitutes have been considered. This article aims to review the properties of the bone graft and various bone substitutes currently available in orthopedic surgery. Synthetic bone substitutes consist of hydroxyapatite, tricalcium phos...... hiện toàn bộ
Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model
Biomaterials Research - Tập 25 - Trang 1-10 - 2021
Minh Khai Le Thieu, Amin Homayouni, Lena Ringsby Hæren, Hanna Tiainen, Anders Verket, Jan Eirik Ellingsen, Hans Jacob Rønold, Johan Caspar Wohlfahrt, Antonio Gonzalez Cantalapiedra, Fernando Maria Guzon Muñoz, Maria Permuy Mendaña, Ståle Petter Lyngstadaas, Håvard Jostein Haugen
Insufficient bone volume around an implant is a common obstacle when dental implant treatment is considered. Limited vertical or horizontal bone dimensions may lead to exposed implant threads following placement or a gap between the bone and implant. This is often addressed by bone augmentation procedures prior to or at the time of implant placement. This study evaluated bone healing when a synthe...... hiện toàn bộ
In vitro photodynamic therapy of methylene blue-loaded acetyl resistant starch nanoparticles
Biomaterials Research - Tập 26 - Trang 1-12 - 2022
In-Kyu Park, Do-Bin Ju, Amal Babu, Jeong-Cheol Lee, Young Jin Pyung, Chong-Su Cho, Hyun-Joong Kim
Combination therapies comprising multiple methods, such as photodynamic therapy have been applied to be complements chemotherapy as they increase the therapeutic efficiency by enabling the intelligent drug delivery to target sites by exposing the photosensitizer to light and activating it in the tumor tissue. This study evaluated in vitro photodynamic therapy of methylene blue (MB)-loaded acetyl r...... hiện toàn bộ
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model
Biomaterials Research - Tập 27 - Trang 1-17 - 2023
Jie Dai, Jianmei Li, Yuqin Zhang, Qian Wen, Yun Lu, Yu Fan, Fancai Zeng, Zhiyong Qian, Yan Zhang, Shaozhi Fu
Hypoxia is a frequent characteristic observed in solid tumors and is strongly associated with tumor metastasis, angiogenesis, and drug resistance. While the vasculature of hypoxic tumor tissues poses obstacles to the efficient administration of conventional drugs, it may prove advantageous in sustaining hyperthermia. Photothermal therapy (PTT) offers a promising treatment strategy that utilizes th...... hiện toàn bộ
Effect of alginate concentration on chondrogenesis of co-cultured human adipose-derived stem cells and nasal chondrocytes: a biological study
Biomaterials Research - Tập 21 - Trang 1-11 - 2017
Y. W. Ewa-Choy, B. Pingguan-Murphy, N. A. Abdul-Ghani, J. Jahendran, K. H. Chua
The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogels system has previously been shown to potentially promote chondrogenesis. The chondrocytic differentiation of co-cultured adipose-derived stem cells (ADSCs) and nasal chondrocytes (NCs) withi...... hiện toàn bộ
Schwann cell durotaxis can be guided by physiologically relevant stiffness gradients
Biomaterials Research - Tập 22 Số 1 - 2018
Elizabeth Evans, Samantha Brady, Anubhav Tripathi, Diane Hoffman–Kim
Abstract Background Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann cells in response to chemical or topographic cues, the current unde...... hiện toàn bộ
Natural bone-mimicking nanopore-incorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration
Biomaterials Research - - 2022
Chansong Kim, Jun Hyuk Heo, Cheolhyun Park, Dai-Hwan Kim, Gyu Sung Yi, Ho Chang Kang, Hyun Suk Jung, Hyun Young Shin, Jung Heon Lee
Abstract Background A considerable number of studies has been carried out to develop alloplastic bone graft materials such as hydroxyapatite (HAP) that mimic the hierarchical structure of natural bones with multiple levels of pores: macro-, micro-, and nanopores. Although nanopores are known to p...... hiện toàn bộ
Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA
Biomaterials Research - Tập 26 - Trang 1-20 - 2022
Chunping Yu, Yi Zhang, Ning Wang, Wensu Wei, Ke Cao, Qun Zhang, Peiying Ma, Dan Xie, Pei Wu, Biao Liu, Jiahao Liu, Wei Xiang, Xing Hu, Xuewen Liu, Jianfei Xie, Jin Tang, Zhi Long, Long Wang, Hongliang Zeng, Jianye Liu
Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has ...... hiện toàn bộ
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