Biomarker Research
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Lymphocyte antigen 6 superfamily member D is a marker of urothelial and squamous differentiation: implications for risk stratification of bladder cancer
Biomarker Research - Tập 8 - Trang 1-12 - 2020
Screening across a multitude of normal and malignant tissues revealed an enhanced expression of lymphocyte antigen 6 superfamily member D (LY6D) in squamous epithelium and urothelium, as well as in malignancies derived therefrom. The aim of this study was to further delineate the protein expression of LY6D in urothelial bladder cancer, with particular attention to its relationship with clinicopath...... hiện toàn bộ
Biomarkers as targets for CAR-T/NK cell therapy in AML
Biomarker Research - Tập 11 - Trang 1-19 - 2023
The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell transplantation (HSCT). However, some patients continue to develop relapsed or refractory AML (R/R-AML). Small molecular targeted drugs require long-time administration. Not all the patients hol...... hiện toàn bộ
Biomarkers in individualized management of chimeric antigen receptor T cell therapy
Biomarker Research - Tập 8 - Trang 1-13 - 2020
The development of chimeric antigen receptor (CAR) T cell immunotherapy has achieved promising results, both in clinical studies and in commercial products for patients with hematologic malignancies. Despite high remission rates of CAR-T cell therapy in previously untreatable, refractory and/or relapsed patients, several challenges in CAR-T therapy remain to be overcome, especially in integrating ...... hiện toàn bộ
Length of hospitalization is associated with selected biomarkers (albumin and lymphocytes) and with co-morbidities: study on 4000 patients
Biomarker Research - Tập 5 - Trang 1-10 - 2017
Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation between low blood levels of albumin, low lymphocytes, and length of stay. The secondary aim was to identify other co-morbidities associated with prolonged hospital stay. Retrospective pilot study w...... hiện toàn bộ
Nuclear protein IK undergoes dynamic subcellular translocation and forms unique nuclear bodies during the cell cycle
Biomarker Research - - 2013
IK is a nuclear protein containing a unique domain named RED due to the presence of a repetitive arginine (R), aspartic (E), and glutamic acid (D) sequence. To date, the function of this protein remains largely unknown despite of a couple of previous studies in the literature. Here we report that depletion of IK via RNA interference results in mitotic arrest. We also demonstrate that IK undergoes ...... hiện toàn bộ
Verification of prognostic expression biomarkers is improved by examining enriched leukemic blasts rather than mononuclear cells from acute myeloid leukemia patients
Biomarker Research - Tập 11 - Trang 1-12 - 2023
Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myeloid leukemia. We hypothesized that examining the homogenous leukemic blasts will yield different biological information and may improve prognostic performance of expression biomarkers. To ass...... hiện toàn bộ
Deubiquitinases in hematological malignancies
Biomarker Research - Tập 9 - Trang 1-23 - 2021
Deubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of most cellular proteins by removing their ubiquitin modification. In recent years, some DUBs, such as USP7, USP9X and USP10, have been identified as promising therapeutic targets in hematological malignancies. Importantly, some potent inhibitors targeting the oncogenic DUBs have been developed, showing pr...... hiện toàn bộ
Autoimmune hemolytic anemia associated with babesiosis
Biomarker Research - Tập 5 - Trang 1-4 - 2017
Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is known to be caused by parasitic and viral infections but has not been well characterized. We describe two cases diagnosed with babesiosis triggering severe AIHA. One case had history of splen...... hiện toàn bộ
Genetic methylation and lymphoid malignancies: biomarkers of tumor progression and targeted therapy
Biomarker Research - Tập 1 - Trang 1-9 - 2013
Lymphoid malignancies, mainly including lymphocytic leukemia and lymphoma, are a group of heterogeneous diseases. Although the clinical outcome of patients has been significantly improved with current immuno-chemotherapy, definitive biomarkers remain to be investigated, particularly those reflecting the malignant behavior of tumor cells and those helpful for developing optimal targeted therapy. Re...... hiện toàn bộ
Triptolide potentiates lung cancer cells to cisplatin-induced apoptosis by selectively inhibiting the NER activity
Biomarker Research - Tập 3 - Trang 1-10 - 2015
Cisplatin and many other platinum-based compounds are important anticancer drugs that are used in treating many cancer types. The development of cisplatin-resistant cancer cells, however, quickly diminishes the effectiveness of these drugs and causes treatment failure. New strategies that reverse cancer cell drug resistance phenotype or sensitize cancer cells to these drugs, therefore, need to be ...... hiện toàn bộ
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