BCL7A is silenced by hypermethylation to promote acute myeloid leukemiaBiomarker Research - Tập 11 - Trang 1-11 - 2023
Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros, Pedro P. Medina
Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood. To date, SWI/SNF complexes are thought to be oncogenic in AML or, at least, necessary to support leukemogenesis. However, mutation patterns in SWI/SNF genes in AML are consisten...... hiện toàn bộ
Biomarkers as targets for CAR-T/NK cell therapy in AMLBiomarker Research - Tập 11 - Trang 1-19 - 2023
Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu, Xiaofeng Shi
The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell transplantation (HSCT). However, some patients continue to develop relapsed or refractory AML (R/R-AML). Small molecular targeted drugs require long-time administration. Not all the patients hol...... hiện toàn bộ
Development and validation of a novel bioassay to determine glucocorticoid sensitivityBiomarker Research - Tập 4 Số 1 - Trang 1-7 - 2016
Williams, Emily L., Stimpson, Madeleine L., Collins, Peter L., Enki, Doyo G., Sinha, Ashish, Lee, Richard W., Dhanda, Ashwin D.
Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a variable response to GCs with approximately 30% being non-responders. This group of GC resistant patients is typically exposed to high-dose GCs and their side-effects before more appropriate imm...... hiện toàn bộ
Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphomaBiomarker Research - Tập 2 - Trang 1-10 - 2014
Francine Foss, Bertrand Coiffier, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Matthew Greenwood, Adam Lerner, Dolores Caballero, Eugeniusz Baran, Ellen Kim, Jean Nichols, Barbara Balser, Julie Wolfson, Sean Whittaker
Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of novel drug therapies for patients with relapsed/refractory aggressive lymphoma requires not only considerations regarding efficacy but also careful evaluation of toxicities as well as overall c...... hiện toàn bộ
Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLCBiomarker Research - Tập 9 - Trang 1-20 - 2021
Weijie Ma, Jie Zeng, Shuai Chen, Yue Lyu, Kyra A. Toomey, Chinh T. Phan, Ken Y. Yoneda, Tianhong Li
Lack of biomarkers and in vitro models has contributed to inadequate understanding of the mechanisms underlying the inferior clinical response to immune checkpoint inhibitors (ICIs) in patients with oncogene-driven non-small cell lung cancer (NSCLC). The effect of small molecule tyrosine kinase inhibitors (TKIs) on peripheral blood mononuclear cells (PBMCs) in 34 patients with oncogene-driven NSCL...... hiện toàn bộ
Whole genome and RNA sequencing analyses for 254 Taiwanese hepatocellular carcinomasBiomarker Research - Tập 11 - Trang 1-12 - 2023
Ya-Sian Chang, Siang-Jyun Tu, Hong-Da Chen, Chin-Chun Chung, Ming-Hon Hsu, Yu-Pao Chou, Ya-Ting Lee, Ju-Chen Yen, Long-Bin Jeng, Jan-Gowth Chang
Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses. We analyzed 254 HCCs by whole genome sequencing and total RNA sequencing, and then used bioinformatic tools to analyze genomic and transcriptomic alterations in coding and non-coding sequences to explore the clinical importance of each sequenc...... hiện toàn bộ
Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancerBiomarker Research - - 2017
Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancersBiomarker Research - Tập 8 - Trang 1-11 - 2020
Yuhang Xiao, Ta Xiao, Wei Ou, Zhining Wu, Jie Wu, Jinming Tang, Bo Tian, Yong Zhou, Min Su, Wenxiang Wang
Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encoding activity, lncRNAs can mediate endogenous gene expression by serving as chromatin remodeler, transcriptional or post-transcriptional modulator, and splicing regulator during gene modificatio...... hiện toàn bộ