Biomarker Research

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BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research - Tập 11 - Trang 1-11 - 2023
Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros, Pedro P. Medina
Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood. To date, SWI/SNF complexes are thought to be oncogenic in AML or, at least, necessary to support leukemogenesis. However, mutation patterns in SWI/SNF genes in AML are consisten...... hiện toàn bộ
Biomarkers as targets for CAR-T/NK cell therapy in AML
Biomarker Research - Tập 11 - Trang 1-19 - 2023
Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu, Xiaofeng Shi
The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell transplantation (HSCT). However, some patients continue to develop relapsed or refractory AML (R/R-AML). Small molecular targeted drugs require long-time administration. Not all the patients hol...... hiện toàn bộ
Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript
Biomarker Research - Tập 9 - Trang 1-5 - 2021
Sophie Voruz, Sabine Blum, Laurence de Leval, Jacqueline Schoumans, Françoise Solly, Olivier Spertini
Relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) has a very poor prognosis with a median overall survival of four to nine months. Achieving a complete molecular response is most often required to obtain a sustained leukemia-free survival after allogeneic hematopoietic stem cell transplantation. Immunotherapies targeting CD19, CD20, or CD22 are very efficient in achieving this ...... hiện toàn bộ
A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature
Biomarker Research - Tập 4 - Trang 1-8 - 2016
Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian, Gary Schiller
Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the ETV6-ABL1 fusion gene are rare in AML and other hematologic malignancies with only thirty-two previously reported cases in the literature, five of which were AML. Herein, we report the cas...... hiện toàn bộ
Development and validation of a novel bioassay to determine glucocorticoid sensitivity
Biomarker Research - Tập 4 Số 1 - Trang 1-7 - 2016
Williams, Emily L., Stimpson, Madeleine L., Collins, Peter L., Enki, Doyo G., Sinha, Ashish, Lee, Richard W., Dhanda, Ashwin D.
Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a variable response to GCs with approximately 30% being non-responders. This group of GC resistant patients is typically exposed to high-dose GCs and their side-effects before more appropriate imm...... hiện toàn bộ
Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphoma
Biomarker Research - Tập 2 - Trang 1-10 - 2014
Francine Foss, Bertrand Coiffier, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Matthew Greenwood, Adam Lerner, Dolores Caballero, Eugeniusz Baran, Ellen Kim, Jean Nichols, Barbara Balser, Julie Wolfson, Sean Whittaker
Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of novel drug therapies for patients with relapsed/refractory aggressive lymphoma requires not only considerations regarding efficacy but also careful evaluation of toxicities as well as overall c...... hiện toàn bộ
Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC
Biomarker Research - Tập 9 - Trang 1-20 - 2021
Weijie Ma, Jie Zeng, Shuai Chen, Yue Lyu, Kyra A. Toomey, Chinh T. Phan, Ken Y. Yoneda, Tianhong Li
Lack of biomarkers and in vitro models has contributed to inadequate understanding of the mechanisms underlying the inferior clinical response to immune checkpoint inhibitors (ICIs) in patients with oncogene-driven non-small cell lung cancer (NSCLC). The effect of small molecule tyrosine kinase inhibitors (TKIs) on peripheral blood mononuclear cells (PBMCs) in 34 patients with oncogene-driven NSCL...... hiện toàn bộ
Whole genome and RNA sequencing analyses for 254 Taiwanese hepatocellular carcinomas
Biomarker Research - Tập 11 - Trang 1-12 - 2023
Ya-Sian Chang, Siang-Jyun Tu, Hong-Da Chen, Chin-Chun Chung, Ming-Hon Hsu, Yu-Pao Chou, Ya-Ting Lee, Ju-Chen Yen, Long-Bin Jeng, Jan-Gowth Chang
Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses. We analyzed 254 HCCs by whole genome sequencing and total RNA sequencing, and then used bioinformatic tools to analyze genomic and transcriptomic alterations in coding and non-coding sequences to explore the clinical importance of each sequenc...... hiện toàn bộ
Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer
Biomarker Research - - 2017
Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers
Biomarker Research - Tập 8 - Trang 1-11 - 2020
Yuhang Xiao, Ta Xiao, Wei Ou, Zhining Wu, Jie Wu, Jinming Tang, Bo Tian, Yong Zhou, Min Su, Wenxiang Wang
Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encoding activity, lncRNAs can mediate endogenous gene expression by serving as chromatin remodeler, transcriptional or post-transcriptional modulator, and splicing regulator during gene modificatio...... hiện toàn bộ
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