Biomarker Research

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BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research - Tập 11 - Trang 1-11 - 2023
Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros, Pedro P. Medina
Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood. To date, SWI/SNF complexes are thought to be oncogenic in AML or, at least, necessary to support leukemogenesis. However, mutation patterns in SWI/SNF genes in AML are consisten... hiện toàn bộ
Biomarkers as targets for CAR-T/NK cell therapy in AML
Biomarker Research - Tập 11 - Trang 1-19 - 2023
Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu, Xiaofeng Shi
The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell transplantation (HSCT). However, some patients continue to develop relapsed or refractory AML (R/R-AML). Small molecular targeted drugs require long-time administration. Not all the patients hol... hiện toàn bộ
Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript
Biomarker Research - Tập 9 - Trang 1-5 - 2021
Sophie Voruz, Sabine Blum, Laurence de Leval, Jacqueline Schoumans, Françoise Solly, Olivier Spertini
Relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) has a very poor prognosis with a median overall survival of four to nine months. Achieving a complete molecular response is most often required to obtain a sustained leukemia-free survival after allogeneic hematopoietic stem cell transplantation. Immunotherapies targeting CD19, CD20, or CD22 are very efficient in achieving this ... hiện toàn bộ
Prognostic significance of miR-194 in endometrial cancer
Biomarker Research - - 2013
Haiyan Zhai, Mihriban Karaayvaz, Peixin Dong, Noriaki Sakuragi, Jingfang Ju
Abstract Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical... hiện toàn bộ
A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature
Biomarker Research - Tập 4 - Trang 1-8 - 2016
Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian, Gary Schiller
Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the ETV6-ABL1 fusion gene are rare in AML and other hematologic malignancies with only thirty-two previously reported cases in the literature, five of which were AML. Herein, we report the cas... hiện toàn bộ
Các dấu hiệu sinh học của hội chứng giải phóng cytokine và độc tính thần kinh liên quan đến liệu pháp tế bào CAR-T Dịch bởi AI
Biomarker Research - Tập 6 - Trang 1-10 - 2018
Zhenguang Wang, Weidong Han
Hội chứng giải phóng cytokine nặng (CRS) và độc tính thần kinh sau liệu pháp tế bào T chimeric antigen receptor (CAR-T) có thể gây nguy hiểm đến tính mạng trong một số trường hợp, và việc quản lý những độc tính này vẫn là một thách thức lớn đối với các bác sĩ. Các nhà nghiên cứu hy vọng hiểu rõ hơn về sinh lý bệnh của CRS và độc tính thần kinh, đồng thời xác định các dấu hiệu sinh học dự đoán có t... hiện toàn bộ
#Hội chứng giải phóng cytokine #độc tính thần kinh #liệu pháp tế bào CAR-T #dấu hiệu sinh học dự đoán.
Update on the first-line treatment for Helicobacter pylori infection - a continuing challenge from an old enemy
Biomarker Research - Tập 5 - Trang 1-6 - 2017
Chih-Chieh Huang, Kuo-Wang Tsai, Tzung-Jiun Tsai, Ping-I Hsu
Because the prevalence of antibiotic resistance markedly increases with time worldwide, anti-H. pylori treatment is continuing to be a great challenge forsphysicians in clinical practice. The Real-world Practice & Expectation of Asia-Pacific Physicians and Patients in Helicobacter Pylori Eradication (REAP-HP) Survey demonstrated that the accepted minimal eradication rate of anti-H. pylori regimen ... hiện toàn bộ
Development and validation of a novel bioassay to determine glucocorticoid sensitivity
Biomarker Research - Tập 4 Số 1 - Trang 1-7 - 2016
Williams, Emily L., Stimpson, Madeleine L., Collins, Peter L., Enki, Doyo G., Sinha, Ashish, Lee, Richard W., Dhanda, Ashwin D.
Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a variable response to GCs with approximately 30% being non-responders. This group of GC resistant patients is typically exposed to high-dose GCs and their side-effects before more appropriate imm... hiện toàn bộ
Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphoma
Biomarker Research - Tập 2 - Trang 1-10 - 2014
Francine Foss, Bertrand Coiffier, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Matthew Greenwood, Adam Lerner, Dolores Caballero, Eugeniusz Baran, Ellen Kim, Jean Nichols, Barbara Balser, Julie Wolfson, Sean Whittaker
Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of novel drug therapies for patients with relapsed/refractory aggressive lymphoma requires not only considerations regarding efficacy but also careful evaluation of toxicities as well as overall c... hiện toàn bộ
Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC
Biomarker Research - Tập 9 - Trang 1-20 - 2021
Weijie Ma, Jie Zeng, Shuai Chen, Yue Lyu, Kyra A. Toomey, Chinh T. Phan, Ken Y. Yoneda, Tianhong Li
Lack of biomarkers and in vitro models has contributed to inadequate understanding of the mechanisms underlying the inferior clinical response to immune checkpoint inhibitors (ICIs) in patients with oncogene-driven non-small cell lung cancer (NSCLC). The effect of small molecule tyrosine kinase inhibitors (TKIs) on peripheral blood mononuclear cells (PBMCs) in 34 patients with oncogene-driven NSCL... hiện toàn bộ
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