Biomarker Research
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BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research - Tập 11 - Trang 1-11 - 2023
Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood. To date, SWI/SNF complexes are thought to be oncogenic in AML or, at least, necessary to support leukemogenesis. However, mutation patterns in SWI/SNF genes in AML are consisten......
Biomarkers as targets for CAR-T/NK cell therapy in AML
Biomarker Research - Tập 11 - Trang 1-19 - 2023
The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell transplantation (HSCT). However, some patients continue to develop relapsed or refractory AML (R/R-AML). Small molecular targeted drugs require long-time administration. Not all the patients hol......
A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature
Biomarker Research - Tập 4 - Trang 1-8 - 2016
Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the ETV6-ABL1 fusion gene are rare in AML and other hematologic malignancies with only thirty-two previously reported cases in the literature, five of which were AML. Herein, we report the cas......
Development and validation of a novel bioassay to determine glucocorticoid sensitivity
Biomarker Research - Tập 4 Số 1 - Trang 1-7 - 2016
Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a variable response to GCs with approximately 30% being non-responders. This group of GC resistant patients is typically exposed to high-dose GCs and their side-effects before more appropriate imm......
Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphoma
Biomarker Research - Tập 2 - Trang 1-10 - 2014
Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of novel drug therapies for patients with relapsed/refractory aggressive lymphoma requires not only considerations regarding efficacy but also careful evaluation of toxicities as well as overall c......
Whole genome and RNA sequencing analyses for 254 Taiwanese hepatocellular carcinomas
Biomarker Research - Tập 11 - Trang 1-12 - 2023
Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses. We analyzed 254 HCCs by whole genome sequencing and total RNA sequencing, and then used bioinformatic tools to analyze genomic and transcriptomic alterations in coding and non-coding sequences to explore the clinical importance of each sequenc......
Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer
Biomarker Research - - 2017
Clinical significance of stromal ER and PR expression in periampullary adenocarcinoma
Biomarker Research - Tập 7 - Trang 1-14 - 2019
Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarkers, and the relevance of female hormone signaling in pancreatic or other periampullary adenocarcinoma remains largely unexplored. The aim of this study was to examine the extent and potential......
Correction: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
Biomarker Research - Tập 12 - Trang 1-2 - 2024
Recent advances in systemic therapy for hepatocellular carcinoma
Biomarker Research - Tập 10 - Trang 1-21 - 2022
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors in the world. Therapeutic options for advanced HCC are limited. Systemic treatment, especially with conventional cytotoxic drugs, is usually ineffective. For more than a decade, sorafenib has been the only systemic drug that has been proven to be clinically effective for treating advanced HCC. However, over the pa......
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