Bioengineering and Translational Medicine
SCOPUS (2020-2025)SCIE-ISI
2380-6761
Mỹ
Cơ quản chủ quản: John Wiley & Sons Inc. , WILEY
Lĩnh vực:
BiotechnologyPharmaceutical ScienceBiomedical Engineering
Các bài báo tiêu biểu
Nanoparticles in the clinic: An update
Tập 4 Số 3 - 2019
AbstractNanoparticle drug delivery systems have been used in the clinic since
the early 1990's. Since that time, the field of nanomedicine has evolved
alongside growing technological needs to improve the delivery of various
therapeutics. Over these past decades, newer generations of nanoparticles have
emerged that are capable of performing additional delivery functions that can
enable treatment vi...
TGF‐β–responsive CAR‐T cells promote anti‐tumor immune function
Tập 3 Số 2 - Trang 75-86 - 2018
AbstractA chimeric antigen receptor (CAR) that responds to transforming growth
factor beta (TGF‐β) enables the engineering of T cells that convert this
immunosuppressive cytokine into a potent T‐cell stimulant. However, clinical
translation of TGF‐β CAR‐T cells for cancer therapy requires the ability to
productively combine TGF‐β responsiveness with tumor‐targeting specificity.
Furthermore, the po...
Reducing neuroinflammation by delivery of IL‐10 encoding lentivirus from multiple‐channel bridges
Tập 1 Số 2 - Trang 136-148 - 2016
AbstractThe spinal cord is unable to regenerate after injury largely due to
growth‐inhibition by an inflammatory response to the injury that fails to
resolve, resulting in secondary damage and cell death. An approach that prevents
inhibition by attenuating the inflammatory response and promoting its resolution
through the transition of macrophages to anti‐inflammatory phenotypes is
essential for t...
Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia
Tập 7 Số 2 - 2022
AbstractTransplantation of olfactory ensheathing cells (OECs) has been
demonstrated to be beneficial for spinal cord injury (SCI) by modulating
neuroinflammation, supporting neuronal survival and promoting angiogenesis.
Besides OECs, the conditioned medium (CM) from OECs has also been proved to have
therapeutic effects for SCI, indicating that the bioactive substances secreted
by OECs are essentia...
Uptake and function of membrane‐destabilizing cationic nanogels for intracellular drug delivery
Tập 4 Số 1 - Trang 17-29 - 2019
AbstractThe design of intracellular drug delivery vehicles demands an in‐depth
understanding of their internalization and function upon entering the cell to
tailor the physicochemical characteristics of these platforms and achieve
efficacious treatments. Polymeric cationic systems have been broadly accepted to
be membrane disruptive thus being beneficial for drug delivery inside the cell.
However,...
Brain‐targeted exosome‐mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti‐tumor effects in glioblastoma animal models
Tập 8 Số 2 - 2023
AbstractThe brain‐targeted delivery of therapeutic oligonucleotides has been
investigated as a new treatment modality for various brain diseases, such as
brain tumors. However, delivery efficiency into the brain has been limited due
to the blood–brain barrier. In this research, brain‐targeted exosome‐mimetic
cell membrane nanovesicles (CMNVs) were designed to enhance the delivery of
therapeutic ol...