Bioengineering and Translational Medicine
SCOPUS (SonsInc.)SCIE-ISI
2380-6761
Mỹ
Cơ quản chủ quản: John Wiley & Sons Inc. , WILEY
Lĩnh vực:
BiotechnologyPharmaceutical ScienceBiomedical Engineering
Các bài báo tiêu biểu
Nanoparticles in the clinic: An updateAbstract Nanoparticle drug delivery systems have been used in the clinic since the early 1990's. Since that time, the field of nanomedicine has evolved alongside growing technological needs to improve the delivery of various therapeutics. Over these past decades, newer generations of nanoparticles have emerged that are capable of performing additional delivery funct... ...
Tập 4 Số 3 - 2019
TGF‐β–responsive CAR‐T cells promote anti‐tumor immune functionAbstract A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF‐β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T‐cell stimulant. However, clinical translation of TGF‐β CAR‐T cells for cancer therapy requires the ability to productively combine TGF‐β responsiveness with tumor‐targeting... ...
Tập 3 Số 2 - Trang 75-86 - 2018
Reducing neuroinflammation by delivery of IL‐10 encoding lentivirus from multiple‐channel bridgesAbstract The spinal cord is unable to regenerate after injury largely due to growth‐inhibition by an inflammatory response to the injury that fails to resolve, resulting in secondary damage and cell death. An approach that prevents inhibition by attenuating the inflammatory response and promoting its resolution through the transition of macrophages to anti‐inflammat... ...
Tập 1 Số 2 - Trang 136-148 - 2016
Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microgliaAbstract Transplantation of olfactory ensheathing cells (OECs) has been demonstrated to be beneficial for spinal cord injury (SCI) by modulating neuroinflammation, supporting neuronal survival and promoting angiogenesis. Besides OECs, the conditioned medium (CM) from OECs has also been proved to have therapeutic effects for SCI, indicating that the bioactive substan... ...
Tập 7 Số 2 - 2022
Uptake and function of membrane‐destabilizing cationic nanogels for intracellular drug deliveryAbstract The design of intracellular drug delivery vehicles demands an in‐depth understanding of their internalization and function upon entering the cell to tailor the physicochemical characteristics of these platforms and achieve efficacious treatments. Polymeric cationic systems have been broadly accepted to be membrane disruptive thus being beneficial for drug d... ...
Tập 4 Số 1 - Trang 17-29 - 2019
Brain‐targeted exosome‐mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti‐tumor effects in glioblastoma animal modelsAbstract The brain‐targeted delivery of therapeutic oligonucleotides has been investigated as a new treatment modality for various brain diseases, such as brain tumors. However, delivery efficiency into the brain has been limited due to the blood–brain barrier. In this research, brain‐targeted exosome‐mimetic cell membrane nanovesicles (CMNVs) were designed to enhan... ...
Tập 8 Số 2 - 2023