Bioengineering and Translational Medicine

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Reducing neuroinflammation by delivery of IL‐10 encoding lentivirus from multiple‐channel bridges
Bioengineering and Translational Medicine - Tập 1 Số 2 - Trang 136-148 - 2016
Daniel J. Margul, Jonghyuck Park, Ryan M. Boehler, Dominique R. Smith, Mitchell A. Johnson, Dylan A. McCreedy, Ting He, Aishani Ataliwala, Todor V. Kukushliev, Jesse Liang, Alireza Sohrabi, Ashley G. Goodman, Christopher M. Walthers, Lonnie D. Shea, Stephanie K. Seidlits
AbstractThe spinal cord is unable to regenerate after injury largely due to growth‐inhibition by an inflammatory response to the injury that fails to resolve, resulting in secondary damage and cell death. An approach that prevents inhibition by attenuating the inflammatory response and promoting its resolution through the transition of macrophages to anti‐inflammatory phenotypes is essential for t... hiện toàn bộ
Brain‐targeted exosome‐mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti‐tumor effects in glioblastoma animal models
Bioengineering and Translational Medicine - Tập 8 Số 2 - 2023
Youngki Lee, Minkyung Kim, Junkyu Ha, Minhyung Lee
AbstractThe brain‐targeted delivery of therapeutic oligonucleotides has been investigated as a new treatment modality for various brain diseases, such as brain tumors. However, delivery efficiency into the brain has been limited due to the blood–brain barrier. In this research, brain‐targeted exosome‐mimetic cell membrane nanovesicles (CMNVs) were designed to enhance the delivery of therapeutic ol... hiện toàn bộ
Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia
Bioengineering and Translational Medicine - Tập 7 Số 2 - 2022
Hong Fan, Zhe Chen, Hai‐Bin Tang, Lequn Shan, Ziyi Chen, Sheng Wang, Dageng Huang, Shichang Liu, Xun Chen, Hao Yang, Dingjun Hao
AbstractTransplantation of olfactory ensheathing cells (OECs) has been demonstrated to be beneficial for spinal cord injury (SCI) by modulating neuroinflammation, supporting neuronal survival and promoting angiogenesis. Besides OECs, the conditioned medium (CM) from OECs has also been proved to have therapeutic effects for SCI, indicating that the bioactive substances secreted by OECs are essentia... hiện toàn bộ
TGF‐β–responsive CAR‐T cells promote anti‐tumor immune function
Bioengineering and Translational Medicine - Tập 3 Số 2 - Trang 75-86 - 2018
Andrew J. Hou, ZeNan Chang, Michael H. Lorenzini, Eugenia Zah, Yvonne Y. Chen
AbstractA chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF‐β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T‐cell stimulant. However, clinical translation of TGF‐β CAR‐T cells for cancer therapy requires the ability to productively combine TGF‐β responsiveness with tumor‐targeting specificity. Furthermore, the po... hiện toàn bộ
Nanoparticles in the clinic: An update
Bioengineering and Translational Medicine - Tập 4 Số 3 - 2019
Aaron C. Anselmo, Samir Mitragotri
AbstractNanoparticle drug delivery systems have been used in the clinic since the early 1990's. Since that time, the field of nanomedicine has evolved alongside growing technological needs to improve the delivery of various therapeutics. Over these past decades, newer generations of nanoparticles have emerged that are capable of performing additional delivery functions that can enable treatment vi... hiện toàn bộ
Uptake and function of membrane‐destabilizing cationic nanogels for intracellular drug delivery
Bioengineering and Translational Medicine - Tập 4 Số 1 - Trang 17-29 - 2019
William B. Liechty, Rebekah L. Scheuerle, Julia E. Vela Ramirez, Nicholas A. Peppas
AbstractThe design of intracellular drug delivery vehicles demands an in‐depth understanding of their internalization and function upon entering the cell to tailor the physicochemical characteristics of these platforms and achieve efficacious treatments. Polymeric cationic systems have been broadly accepted to be membrane disruptive thus being beneficial for drug delivery inside the cell. However,... hiện toàn bộ
Tổng số: 6   
  • 1