Polyphosphates as an energy source for growth of Saccharomyces cerevisiaeBiochemistry (Moscow) - Tập 79 - Trang 478-482 - 2014
L. V. Trilisenko, T. V. Kulakovskaya
Cells of the yeast Saccharomyces cerevisiae with a low content of polyphosphates (polyP) are characterized by disturbance of growth in medium with 0.5% glucose. The parent strain with polyP level reduced by phosphate starvation had a longer lag phase. The growth rate of strains with genetically determined low content of polyP due to their enhanced hydrolysis (CRN/pMB1_PPN1 Sc is a superproducer of...... hiện toàn bộ
Klotho protein: Its role in aging and central nervous system pathologyBiochemistry (Moscow) - - 2017
I. S. Boksha, T. A. Prokhorova, O. K. Savushkina, E. B. Tereshkina
This review is devoted to Klotho protein and recent evidences for its functions in the brain. Information on transcriptional regulation of the klotho gene and posttranslational modifications of the protein resulting in multiple forms of Klotho is reviewed. Evidence is summarized that Klotho regulates the activity of protein factors, enzymes, and receptors, including data suggesting the importance ...... hiện toàn bộ
Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeletonBiochemistry (Moscow) - Tập 80 - Trang 1288-1297 - 2015
E. L. Vilitkevich, A. Y. Khapchaev, D. S. Kudryashov, A. V. Nikashin, J. P. Schavocky, T. J. Lukas, D. M. Watterson, V. P. Shirinsky
High molecular weight myosin light chain kinase (MLCK210) is a multifunctional protein involved in myosin II activation and integration of cytoskeletal components in cells. MLCK210 possesses actin-binding regions both in the central part of the molecule and in its N-terminal tail domain. In HeLa cells, mitotic protein kinase Aurora B was suggested to phosphorylate MLCK210 N-terminal tail at serine...... hiện toàn bộ
HuR stabilizes lnc-Sox5 mRNA to promote tongue carcinogenesisBiochemistry (Moscow) - Tập 82 - Trang 438-445 - 2017
Lifang Wang, Shucheng Ye, Junye Wang, Zhenfang Gu, Yanhui Zhang, Chunmei Zhang, Xuezhen Ma
Long noncoding RNAs (lncRNAs) have been recently regarded as systemic regulators in multiple biological processes including tumorigenesis. In this study, we report an ultra-highly expressed lncRNA, lnc-Sox5, in tongue tumor tissues. The results imply that lnc-Sox5 may play vital role in tongue carcinoma progression. We observed that the growth of Tca8113 cells was suppressed by lnc-Sox5 downregula...... hiện toàn bộ
Macrophage/foam cell is an attribute of inflammation: Mechanisms of formation and functional roleBiochemistry (Moscow) - Tập 77 - Trang 327-338 - 2012
M. I. Dushkin
Transformation of macrophages into foam cells is traditionally considered in the context of atherogenesis, because lipid accumulation is believed to be a consequence of uptake of oxidized low density lipoproteins (oxLDL) through scavenger receptors (SR) of macrophages. However, an excessive uptake of oxLDL is recently shown to trigger compensatory mechanisms of cholesterol elimination from macroph...... hiện toàn bộ