Biochemistry (Moscow)

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Biological effects of 3,5-diiodothyronine (T2)
Biochemistry (Moscow) - Tập 70 Số 2 - Trang 164-172 - 2005
Fernando Goglia
Recombinant Human Cyclophilin A in Combination with Adoptive T-cell Therapy Improves the Efficacy of Cancer Immunotherapy in Experimental Models in vivo
Biochemistry (Moscow) - Tập 88 - Trang 590-599 - 2023
Anastasiia A. Kalinina, Dmitry B. Kazansky, Ludmila M. Khromykh
Adoptive T-cell therapy (ACT) is successfully applied in cancer treatment; however, its efficiency can be limited by a low viability, short persistence time, and loss of functional activity of T-cells after adoptive transfer. The search for novel immunomodulators that can improve the viability, expansion, and functions of T-cells after their infusion with the minimal side effects could contribute ...... hiện toàn bộ
HuR stabilizes lnc-Sox5 mRNA to promote tongue carcinogenesis
Biochemistry (Moscow) - Tập 82 - Trang 438-445 - 2017
Lifang Wang, Shucheng Ye, Junye Wang, Zhenfang Gu, Yanhui Zhang, Chunmei Zhang, Xuezhen Ma
Long noncoding RNAs (lncRNAs) have been recently regarded as systemic regulators in multiple biological processes including tumorigenesis. In this study, we report an ultra-highly expressed lncRNA, lnc-Sox5, in tongue tumor tissues. The results imply that lnc-Sox5 may play vital role in tongue carcinoma progression. We observed that the growth of Tca8113 cells was suppressed by lnc-Sox5 downregula...... hiện toàn bộ
Reproducible Peak Clusters on Differential Mouse Mortality Curves and Their Relation to the Gompertz Model
Biochemistry (Moscow) - Tập 83 - Trang 836-845 - 2018
A. G. Malygin
It is shown that differentiation of mouse mortality curves (number of animals that died at a certain age plotted versus their lifespan) results in the appearance of eight clearly distinguished clusters of peaks corresponding to increased mortality rates. Smoothing of the original mortality curves and subsequent transformation of the differential mortality curves according to the Gompertz model mak...... hiện toàn bộ
Transcription Factor Nrf2 and Mitochondria – Friends or Foes in the Regulation of Aging Rate
Biochemistry (Moscow) - - 2022
Gregory A. Shilovsky, Vasily V. Ashapkin
Properties of mutant reaction centers of Rhodobacter sphaeroides with substitutions of histidine L153, the axial Mg2+ ligand of bacteriochlorophyll BA
Biochemistry (Moscow) - Tập 74 - Trang 452-460 - 2009
M. M. Leonova, L. G. Vasilieva, R. A. Khatypov, V. A. Boichenko, V. A. Shuvalov
Mutant reaction centers (RC) from Rhodobacter sphaeroides have been studied in which histidine L153, the axial ligand of the central Mg atom of bacteriochlorophyll BA molecule, was substituted by cysteine, methionine, tyrosine, or leucine. None of the mutations resulted in conversion of the bacteriochlorophyll BA to a bacteriopheophytin molecule. Isolated H(L153)C and H(L153)M RCs demonstrated spe...... hiện toàn bộ
Heterologous expression and isolation of influenza A virus nuclear export protein NEP
Biochemistry (Moscow) - Tập 82 - Trang 1529-1537 - 2017
A. O. Golovko, O. N. Koroleva, V. L. Drutsa
Influenza A virus nuclear export protein NEP (NS2, 14.4 kDa) plays a key role in various steps of the virus life cycle. Highly purified protein preparations are required for structural and functional studies. In this study, we designed a series of Escherichia coli plasmid constructs for highly efficient expression of the NEP gene under control of the constitutive trp promoter. An efficient method ...... hiện toàn bộ
Resistance of Dextran-Modified Hyaluronidase to Inhibition by Heparin
Biochemistry (Moscow) - - 2001
A. V. Maksimenko, Yu. V. Schechilina, E. G. Tischenko
Properties of native and aldehyde dextran-modified hyaluronidase (with surface amino group modification about 98%) were investigated. Optimal endoglycosidase activity of the native enzyme was observed at 0.15 M NaCl and pH 5.5 and electrostatic interactions influenced the enzyme activity. The inhibitory effect of heparin on hyaluronidase activity slightly differed at pH 5.5 (1.5-fold inhibition) a...... hiện toàn bộ
High salt stress in coupled and uncoupled thylakoid membranes: A comparative study
Biochemistry (Moscow) - Tập 74 - Trang 620-624 - 2009
P. Mehta, A. Jajoo, S. Mathur, S. I. Allakhverdiev, S. Bharti
The effect of high salt concentration on photosystem II (PS II) electron transport rates and chlorophyll a fluorescence induction kinetics was investigated in coupled and uncoupled spinach thylakoid membranes. With increase in salt concentration, the rates of electron transport mediated by PS II and the F v/F m ratio were affected more in uncoupled t...... hiện toàn bộ
How Proteins Pack into Crystals: Nuclei Achieve Translation Symmetries by Growing
Biochemistry (Moscow) - Tập 69 - Trang 742-747 - 2004
Dan Feng, Zong-Hao Zeng
How protein molecules pack into a crystal remains problematic. Packing units are direct materials for packing into crystals. The group generator method is introduced for automatically identifying the packing unit. By introducing deviations into the nucleation stage of crystallization, we proved that these deviations diminish in further packing. This process illustrates how translation symmetries a...... hiện toàn bộ
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