Latest developments in MUC1 immunotherapyBiochemical Society Transactions - Tập 46 Số 3 - Trang 659-668 - 2018
Joyce Taylor‐Papadimitriou, Joy Burchell, Rosalind Graham, Richard Beatson
Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas. Moreover, MUC1 is expressed by some ha...... hiện toàn bộ
Glyoxalase I inhibitors in cancer chemotherapyBiochemical Society Transactions - Tập 31 Số 6 - Trang 1378-1382 - 2003
Donald J. Creighton, Zhe-Bin Zheng, Ronald J. Holewinski, Diana S. Hamilton, Julie L. Eiseman
Several recent developments suggest that the GSH-dependent glyoxalase enzyme system deserves renewed interest as a potential target for antitumour drug development. This summary focuses on the design and development of new classes of tumoricidal agents that specifically target this elementary detoxification pathway in order to induce elevated concentrations of cytotoxic methylglyoxal in tu...... hiện toàn bộ
Systems biology markup language: Level 2 and beyondBiochemical Society Transactions - Tập 31 Số 6 - Trang 1472-1473 - 2003
Andrew Finney, Michael Hucka
The SBML (systems biology markup language) is a standard exchange format for computational models of biochemical networks. We continue developing SBML collaboratively with the modelling community to meet their evolving needs. The recently introduced SBML Level 2 includes several enhancements to the original Level 1, and features under development for SBML Level 3 include model composition,...... hiện toàn bộ
Tau protein in Alzheimer's diseaseBiochemical Society Transactions - Tập 23 Số 1 - Trang 80-86 - 1995
Michel Goedert, Ross Jakes, Maria Grazia Spillantini, R. Anthony Crowther, Phillip Cohen, Eugeen Vanmechelen, A. Probst, Jürgen Götz, Kurt Bürki
Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?Biochemical Society Transactions - Tập 40 Số 5 - Trang 950-954 - 2012
Andrés Binolfi, François‐Xavier Theillet, Philipp Selenko
The notion that human α-synuclein is an intrinsically disordered monomeric protein was recently challenged by a postulated α-helical tetramer as the physiologically relevant protein structure. The fact that this alleged conformation had evaded detection for so many years was primarily attributed to a widely used denaturation protocol to purify recombinant α-synuclein. In the present paper,...... hiện toàn bộ