Biochemical Society Transactions

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Latest developments in MUC1 immunotherapy
Biochemical Society Transactions - Tập 46 Số 3 - Trang 659-668 - 2018
Joyce Taylor‐Papadimitriou, Joy Burchell, Rosalind Graham, Richard Beatson
Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas. Moreover, MUC1 is expressed by some ha...... hiện toàn bộ
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
Biochemical Society Transactions - Tập 21 Số 2 - Trang 330-334 - 1993
Joseph S. Beckman, John P. Crow
Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident
Biochemical Society Transactions - Tập 21 Số 3 - Trang 314S-314S - 1993
Ludmila G. Korkina, Igor B AFANAS'EF, Anthony T. Diplock
Regulation of pineal serotonin N-acetyltransferase activity
Biochemical Society Transactions - Tập 20 Số 2 - Trang 299-304 - 1992
David C. Klein, Nicolas L. Schaad, M. A. A. Namboordiri, Yu Li, Joan L. Weller
Tau protein in Alzheimer's disease
Biochemical Society Transactions - Tập 23 Số 1 - Trang 80-86 - 1995
Michel Goedert, Ross Jakes, Maria Grazia Spillantini, R. Anthony Crowther, Phillip Cohen, Eugeen Vanmechelen, A. Probst, Jürgen Götz, Kurt Bürki
Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?
Biochemical Society Transactions - Tập 40 Số 5 - Trang 950-954 - 2012
Andrés Binolfi, François‐Xavier Theillet, Philipp Selenko
The notion that human α-synuclein is an intrinsically disordered monomeric protein was recently challenged by a postulated α-helical tetramer as the physiologically relevant protein structure. The fact that this alleged conformation had evaded detection for so many years was primarily attributed to a widely used denaturation protocol to purify recombinant α-synuclein. In the present paper,...... hiện toàn bộ
A new method for measuring antioxidant activity
Biochemical Society Transactions - Tập 21 Số 2 - Trang 95S-95S - 1993
Nicholas J. Miller, Catherine Rice‐Evans, Michael J. Davies
Spatial gradients controlling spindle assembly
Biochemical Society Transactions - Tập 43 Số 1 - Trang 7-12 - 2015
Lesley N. Weaver, Claire Walczak
The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle ...... hiện toàn bộ
Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries
Biochemical Society Transactions - Tập 31 Số 3 - Trang 723-727 - 2003
Nigel M. Hooper
Neprilysin [or neutral endopeptidase (NEP)] and angiotensin-converting enzyme (ACE) are zinc metallopeptidases involved in the extracellular metabolism of biologically active peptides. Recent genomic advances have led to the identification of novel homologues of each of these ectoenzymes and new physiological and pathological roles are emerging for them. The structures of each of these pep...... hiện toàn bộ
Strombine [N-(carboxymethyl)-d-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine] dehydrogenase from the mussel Mytilus edulis L.
Biochemical Society Transactions - Tập 9 Số 4 - Trang 297-298 - 1981
P. R. Dando
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