Biochemical Journal

SCIE-ISI SCOPUS (1945-2023)

  1470-8728

  0264-6021

  Anh Quốc

Cơ quản chủ quản:  Portland Press, Ltd.

Lĩnh vực:
Molecular BiologyCell BiologyBiochemistry

Các bài báo tiêu biểu

How mitochondria produce reactive oxygen species
Tập 417 Số 1 - Trang 1-13 - 2009
Michael P. Murphy
The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2•−) is the proximal mitochondrial ROS, and in the present review I outline the principles that govern O2•− production within the matrix of ...... hiện toàn bộ
Caspases: the executioners of apoptosis
Tập 326 Số 1 - Trang 1-16 - 1997
Gerald M. Cohen
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes a protein required for developmental cell death. Since the recognition that CED-3 has sequence identity with the mammalian cysteine protease interleukin-1β-converting enzyme (ICE), a family of at least 10 related c...... hiện toàn bộ
Inositol trisphosphate and diacylglycerol as second messengers
Tập 220 Số 2 - Trang 345-360 - 1984
Michael J. Berridge
The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay
Tập 133 Số 3 - Trang 529-538 - 1973
A.E. Bolton, W. M. Hunter
1. A new method is described for labelling proteins to high specific radioactivities with 125I. The protein is treated with a 125I-labelled acylating agent, iodinated 3-(4-hydroxyphenyl)propionic acid N-hydroxysuccinimide ester, which reacts with free amino groups in the protein molecule to attach the 125I-labelled groups by amide bonds. 2. Three protein hormones have been labelled by this...... hiện toàn bộ
A classification of glycosyl hydrolases based on amino acid sequence similarities
Tập 280 Số 2 - Trang 309-316 - 1991
Bernard Henrissat
The amino acid sequences of 301 glycosyl hydrolases and related enzymes have been compared. A total of 291 sequences corresponding to 39 EC entries could be classified into 35 families. Only ten sequences (less than 5% of the sample) could not be assigned to any family. With the sequences available for this analysis, 18 families were found to be monospecific (containing only one EC number)...... hiện toàn bộ
Nguyên Tắc của Dẫn Truyền Tín Hiệu của Cytokine Loại Interleukin (IL)-6 và Sự Điều Hòa của Nó Dịch bởi AI
Tập 374 Số 1 - Trang 1-20 - 2003
Peter C. Heinrich, Iris Behrmann, Elisabeth Letellier, Heike M. Hermanns, Gerhard Müller‐Newen, Fred Schaper
Các cytokine loại IL-6 bao gồm IL-6, IL-11, LIF (yếu tố ức chế bạch cầu), OSM (oncostatin M), yếu tố dưỡng thần kinh mi, cardiotrophin-1 và cytokine giống cardiotrophin là một họ quan trọng của các chất trung gian tham gia điều hòa phản ứng cấp tính đối với tổn thương và nhiễm trùng. Bên cạnh chức năng của chúng trong viêm và đáp ứng miễn dịch, những cytokine này cũng đóng một vai trò quan...... hiện toàn bộ
#IL-6-type cytokines #JAK/STAT signaling #MAPK cascades #cytokine regulation #molecular mechanisms #inflammation #immune response #hematopoiesis #rheumatoid arthritis #cancer
Histone deacetylases (HDACs): characterization of the classical HDAC family
Tập 370 Số 3 - Trang 737-749 - 2003
Annemieke J.M. de Ruijter, Albert H. Gennip, Huib N. Caron, Stephan Kemp, André B. P. Kuilenburg
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetylation is probably the best understood of these modifications: hyperacetylation leads to an increase in the expression of particular genes, and ...... hiện toàn bộ
Nitric oxide synthases in mammals
Tập 298 Số 2 - Trang 249-258 - 1994
Richard G. Knowles, Salvador Moncada
Interleukin-6 and the acute phase response
Tập 265 Số 3 - Trang 621-636 - 1990
Peter C. Heinrich, José V. Castell, Tilo Andus
Arginine metabolism: nitric oxide and beyond
Tập 336 Số 1 - Trang 1-17 - 1998
Guoyao Wu, Sidney M. Morris
Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine. Of the enzymes that catalyse rate-controlling steps in arginine synthesis and catabolism, argininosuccinate synthase, the two arginase isoenzymes, the three nitric oxide syntha...... hiện toàn bộ