Biochemical Journal

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Cloning of a lymphatic peptide/histidine transporter
Biochemical Journal - Tập 356 Số 1 - Trang 53-60 - 2001
Kazuko Sakata, Toshihide Yamashita, Mitsuyo MAEDA, Yoshinori Moriyama, Shoichi Shimada, Masaya TOHYAMA
Although peptide transport across the plasma membrane has been characterized well in the kidney and the intestine, the functional relevance of this transport in other organs has not been addressed. Here we report the cloning of a cDNA for a novel peptide/histidine transporter found in the rat (rPHT2), whose mRNA is expressed mainly in the lymphatic system. rPHT2 encodes a protein of 582 amino acid... hiện toàn bộ
Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms
Biochemical Journal - Tập 375 Số 3 - Trang 561-565 - 2003
Emyr Lloyd‐Evans, Dori Pelled, Christian Riebeling, Anthony H. Futerman
Recently, we demonstrated that the GSL (glycosphingolipid), GlcCer (glucosylceramide), modulates Ca2+ release from intracellular stores and from microsomes by sensitizing the RyaR (ryanodine receptor), a major Ca2+-release channel of the endoplasmic reticulum, whereas the lyso derivative of GlcCer, namely GlcSph (glucosylsphingosine), induced Ca2+ release via a mechanism independent of the RyaR [L... hiện toàn bộ
‘Unknown’ proteins and ‘orphan’ enzymes: the missing half of the engineering parts list – and how to find it
Biochemical Journal - Tập 425 Số 1 - Trang 1-11 - 2010
Andrew D. Hanson, Anne Pribat, Jeffrey C. Waller, Valérie de Crécy‐Lagard
Like other forms of engineering, metabolic engineering requires knowledge of the components (the ‘parts list’) of the target system. Lack of such knowledge impairs both rational engineering design and diagnosis of the reasons for failures; it also poses problems for the related field of metabolic reconstruction, which uses a cell's parts list to recreate its metabolic activities in silico. Despite... hiện toàn bộ
Pathways of peroxynitrite oxidation of thiol groups
Biochemical Journal - Tập 322 Số 1 - Trang 167-173 - 1997
Celia Quijano, Beatriz Álvarez, R Gatti, Ohára Augusto, Rafael Radí
Peroxynitrite mediates the oxidation of the thiol group of both cysteine and glutathione. This process is associated with oxygen consumption. At acidic pH and a cysteine/peroxynitrite molar ratio of ≤ 1.2, there was a single fast phase of oxygen consumption, which increased with increasing concentrations of both cysteine and oxygen. At higher molar ratios the profile of oxygen consumption became b... hiện toàn bộ
Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide
Biochemical Journal - Tập 390 Số 3 - Trang 695-702 - 2005
A. A. Malina, Yechiel Shai
Many studies have shown that an amphipathic structure and a threshold of hydrophobicity of the peptidic chain are crucial for the biological function of AMPs (antimicrobial peptides). However, the factors that dictate their cell selectivity are not yet clear. In the present study, we show that the attachment of aliphatic acids with different lengths (10, 12, 14 or 16 carbon atoms) to the N-terminu... hiện toàn bộ
Properties of follicle-stimulating-hormone receptor in cell membranes of bovine testis
Biochemical Journal - Tập 149 Số 1 - Trang 123-132 - 1975
K. W. Cheng
A simple method for preparing plasma membranes from bovine testes is described. Bovine testicular receptor has a high affinity and specificity for 125I-labelled human FSH (follicle-stimulating hormone). The specific binding of 125I-labelled human FSH to the plasma membranes is a saturable process with respect to the amounts of receptor protein and FSH added. The association and dissociation of 125... hiện toàn bộ
Identification of N-acetyl-d-glucosamine-specific lectins from rat liver cytosolic and nuclear compartments as heat-shock proteins
Biochemical Journal - Tập 360 Số 1 - Trang 179 - 2001
Tony Lefebvre, Caroline Cieniewski‐Bernard, Jérôme Lemoine, Yann Guérardel, Y. Leroy, Jean‐Pierre Zanetta, Jean‐Claude Michalski
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
Biochemical Journal - Tập 425 Số 2 - Trang 313-325 - 2010
Andrew G. Cox, Christine C. Winterbourn, Mark B. Hampton
Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from conventional antioxidants, including a susceptibility to inactivation by hyperoxidation in the presence of excess peroxide and the ability to form complex oligomeric structures. These properties, combined with a high cell... hiện toàn bộ
The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication
Biochemical Journal - Tập 381 Số 2 - Trang 437-446 - 2004
Anderson Assunção Andrade, Patrícia N. G. Silva, Anna Carolina Toledo da Cunha Pereira, Lirlândia P. Sousa, Paulo César Peregrino Ferreira, Ricardo T. Gazzinelli, Erna Geessien Kroon, Catherine Ropert, Cláudio Antônio Bonjardim
Early events play a decisive role in virus multiplication. We have shown previously that activation of MAPK/ERK1/2 (mitogen-activated protein kinase/extracellular-signal-regulated kinase 1/2) and protein kinase A are pivotal for vaccinia virus (VV) multiplication [de Magalhães, Andrade, Silva, Sousa, Ropert, Ferreira, Kroon, Gazzinelli and Bonjardim (2001) J. Biol. Chem. 276, 38353–38360]. In the ... hiện toàn bộ
Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana
Biochemical Journal - Tập 363 Số 2 - Trang 365 - 2002
Julie E. Ralton, Kylie A. Mullin, Malcolm J. McConville
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