P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions Tập 5 - Trang 1-9 - 2015
Ying-Ju Lin, Tsung-Jung Ho, Ting-Hsu Lin, Wei-Yi Hsu, Shao-Mei Huang, Chiu-Chu Liao, Chih-Ho Lai, Xiang Liu, Hsinyi Tsang, Chien-Chen Lai, Fuu-Jen Tsai
Background: Wilson’s disease (WD) is a genetic disorder involving the metabolism
of copper. WD patients exhibit a wide range of disease phenotypes, including
Kayser-Fleischer rings in the cornea, predominant progressive hepatic disease,
neurological diseases, and/or psychiatric illnesses, among others. Patients with
exon12 mutations of the ATP7B gene have progressive hepatic disease. An ATP7B
gene... hiện toàn bộ
Tissue distribution of naringenin conjugated metabolites following repeated dosing of naringin to rats Tập 4 - Trang 1-6 - 2014
Shiuan-Pey Lin, Yu-Chi Hou, Shang-Yuan Tsai, Meng-Ju Wang, Pei-Dawn Lee Chao
Background: Naringin is a major antioxidant in Citrus fruits and herbs. To
clarify molecular forms distributed to various tissues, we investigated tissue
distribution of naringin and relevant metabolites in rats after repeated dosing.
Methods: Male Sprague-Dawley rats were orally administered naringin (210 mg/kg)
twice daily for eight days. At 6 h post the 17th dose, various tissues including
live... hiện toàn bộ
Cryotherapy: A viable tool to remove broncholiths under flexible bronchoscopy Tập 6 - Trang 1-4 - 2016
Sabrina N. Campbell, Deepa Lala, Edmundo Rubio
Broncholithiasis is the presence of calcific material within the
tracheobronchial tree. Asymptomatic patients can be managed with observation
only, whereas symptomatic disease requires surgery, rigid or flexible
bronchoscopic removal. Recent reports have shown that flexible bronchoscopy can
be a safe and effective option for removal of loose in addition to partially
imbedded broncholiths. We prese... hiện toàn bộ
Personalized medicine in Type 2 Diabetes Tập 4 - Trang 1-8 - 2014
Wen-Ling Liao, Fuu-Jen Tsai
Type 2 diabetes (T2D) is a global public health concern, its prevalence in Asia,
especially Taiwan, rising every year. The risk of developing T2D and diabetes
complications is not only controlled by environmental but also by genetic
factors. Genetic association studies have shown polymorphisms at specific loci
may help identify individuals at greatest risk and response to oral antidiabetic
drugs. ... hiện toàn bộ
Lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia suppress the tumorigenicity of head and neck cancer cells in vivo Tập 4 - Trang 1-5 - 2014
Ching-Wen Chang, Yu-Syuan Chen, Chien-Chih Chen, Chin-Chu Chen, Sen-Je Sheu, Ting-wei Lin, Te-Chang Lee, Jeng-Fan Lo
Head and neck cancer (HNC) is one of the most common forms of cancer in Taiwan.
In addition, head and neck cancer cells (HNCs) are highly tumorigenic and
resistant to conventional therapy. Therefore, development of new therapeutic
regimens that are adjuvant to conventional treatments would benefit future head
and neck cancer therapy. In this study, we found that the lyophilized particles
and ethan... hiện toàn bộ
Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury Tập 6 - Trang 1-8 - 2016
Lung-Che Chen, Li-Hong Hu, Mei-Chin Yin
Protective effects of boswellic acid (BA) against acetaminophen (APAP)-induced
hepatotoxicity in Balb/ cA mice were examined. BA, at 0.05 or 0.1%, was supplied
for 4 weeks. Acute liver injury was induced by APAP treatment. Results showed
that BA intake increased hepatic BA bioavailability. APAP treatment decreased
glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized
glutat... hiện toàn bộ
Wound dressings – a review Tập 5 - Trang 1-5 - 2015
Selvaraj Dhivya, Viswanadha Vijaya Padma, Elango Santhini
Wound healing is a dynamic and complex process which requires suitable
environment to promote healing process. With the advancement in technology, more
than 3000 products have been developed to treat different types of wounds by
targeting various aspects of healing process. The present review traces the
history of dressings from its earliest inception to the current status and also
discusses the a... hiện toàn bộ