Estimation of genomic breeding values using the Horseshoe priorBMC Proceedings - Tập 8 - Trang 1-6 - 2014
Ricardo Pong-Wong
A method for estimating genomic breeding values (GEBV) based on the Horseshoe prior was introduced and used on the analysis of the 16th QTLMAS workshop dataset, which resembles three milk production traits. The method was compared with five commonly used methods: Bayes A, Bayes B, Bayes C, Bayesian Lasso and GLUP. The main difference between the methods is the prior distribution assumed during the...... hiện toàn bộ
Genome-wide association studies of rheumatoid arthritis data via multiple hypothesis testing methods for correlated testsBMC Proceedings - Tập 3 - Trang 1-5 - 2009
Guolian Kang, Douglas K Childers, Nianjun Liu, Kui Zhang, Guimin Gao
Genome-wide association studies often involve testing hundreds of thousands of single-nucleotide polymorphisms (SNPs). These tests may be highly correlated because of linkage disequilibrium among SNPs. Multiple testing correction ignoring the correlation among markers, as is done in the Bonferroni procedure, can cause loss of power. Several multiple testing adjustment methods accounting for correl...... hiện toàn bộ
A combined strategy for quantitative trait loci detection by genome-wide associationBMC Proceedings - Tập 3 - Trang 1-8 - 2009
Alex C Lam, Joseph Powell, Wen-Hua Wei, Dirk-Jan de Koning, Chris S Haley
We applied a range of genome-wide association (GWA) methods to map quantitative trait loci (QTL) in the simulated dataset provided by the 12th QTLMAS workshop in order to derive an effective strategy. A variance component linkage analysis revealed QTLs but with low resolution. Three single-marker based GWA methods were then applied: Transmission Disequilibrium Test and single marker regression, fi...... hiện toàn bộ