BMC Molecular and Cell Biology
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Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency
BMC Molecular and Cell Biology - Tập 21 - Trang 1-10 - 2020
Deficiency in thymidine kinase 2 (TK2) or p53 inducible ribonucleotide reductase
small subunit (p53R2) is associated with tissue specific mitochondrial DNA
(mtDNA) depletion. To understand the mechanisms of the tissue specific mtDNA
depletion we systematically studied key enzymes in dTMP synthesis in
mitochondrial and cytosolic extracts prepared from adult rat tissues. In
addition to mitochondrial...
Intracellular pH regulation: characterization and functional investigation of H+ transporters in Stylophora pistillata
BMC Molecular and Cell Biology - Tập 22 - Trang 1-19 - 2021
Reef-building corals regularly experience changes in intra- and extracellular H+
concentrations ([H+]) due to physiological and environmental processes.
Stringent control of [H+] is required to maintain the homeostatic acid-base
balance in coral cells and is achieved through the regulation of intracellular
pH (pHi). This task is especially challenging for reef-building corals that
share an endosym...
Glutantβase: a database for improving the rational design of glucose-tolerant β-glucosidases
BMC Molecular and Cell Biology - Tập 21 - Trang 1-15 - 2020
Β-glucosidases are key enzymes used in second-generation biofuel production.
They act in the last step of the lignocellulose saccharification, converting
cellobiose in glucose. However, most of the β-glucosidases are inhibited by high
glucose concentrations, which turns it a limiting step for industrial
production. Thus, β-glucosidases have been targeted by several studies aiming to
understand the...
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction
BMC Molecular and Cell Biology - Tập 23 Số 1 - 2022
Abstract Background SARS-CoV-2, the causative agent of COVID-19 pandemic is a
RNA virus prone to mutations. Formation of a stable binding interface between
the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and
Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry. RBD
has been shown to mutate frequently during pandemic. Although, a few mutations
in RBD exhibit e...
Bigram-PGK: phosphoglycerylation prediction using the technique of bigram probabilities of position specific scoring matrix
BMC Molecular and Cell Biology - Tập 20 - Trang 1-9 - 2019
The biological process known as post-translational modification (PTM) is a
condition whereby proteomes are modified that affects normal cell biology, and
hence the pathogenesis. A number of PTMs have been discovered in the recent
years and lysine phosphoglycerylation is one of the fairly recent developments.
Even with a large number of proteins being sequenced in the post-genomic era,
the identifi...
Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing
BMC Molecular and Cell Biology - Tập 23 - Trang 1-13 - 2022
The single-cell platform provided revolutionary way to study cellular biology.
Technologically, a sophistic protocol of isolating qualified single cells would
be key to deliver to single-cell platform, which requires high cell viability,
high cell yield and low content of cell aggregates or doublets. For
musculoskeletal tissues, like bone, cartilage, nucleus pulposus and tendons, as
well as their ...
Effect of bacterial infection on sperm quality and DNA fragmentation in subfertile men with Leukocytospermia
BMC Molecular and Cell Biology - Tập 22 - Trang 1-10 - 2021
Although bacterial infections have been recognized as a possible cause of male
infertility, the effect of bacterial infections on sperm quality and sperm DNA
fragmentation remains controversial. The current study aimed to investigate the
prevalence rate of bacterial infection in subfertile men and its effect on semen
quality. Seminal fluid was collected from 172 male members of infertile couples
a...
Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
BMC Molecular and Cell Biology - Tập 21 - Trang 1-10 - 2020
The SMC5/6 complex, cohesin and condensin are the three mammalian members of the
structural maintenance of chromosomes (SMC) family, large ring-like protein
complexes that are essential for genome maintenance. The SMC5/6 complex is the
least characterized complex in mammals; however, it is known to be involved in
homologous recombination repair (HRR) and chromosome segregation. In this study,
a ye...
Using parallelized incremental meta-docking can solve the conformational sampling issue when docking large ligands to proteins
BMC Molecular and Cell Biology - Tập 20 - Trang 1-15 - 2019
Docking large ligands, and especially peptides, to protein receptors is still
considered a challenge in computational structural biology. Besides the issue of
accurately scoring the binding modes of a protein-ligand complex produced by a
molecular docking tool, the conformational sampling of a large ligand is also
often considered a challenge because of its underlying combinatorial complexity.
In ...
Correction to: Influence of mechanical and TGF-β3 stimulation on the tenogenic differentiation of tonsil-derived mesenchymal stem cells
BMC Molecular and Cell Biology - Tập 23 Số 1 - 2022
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