BMC Molecular and Cell Biology

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Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction
BMC Molecular and Cell Biology - Tập 23 Số 1 - 2022
Shijulal Nelson-Sathi, Perunthottathu K Umasankar, Easwaran Sreekumar, Radhakrishnan R. Nair, Iype Joseph, Sai Ravi Chandra Nori, Jamiema Sara Philip, Roshny Prasad, K. V. Navyasree, Shikha Ramesh, Heera Pillai, Sanu Ghosh, T. R. Santosh Kumar, M. Radhakrishna Pillai
Abstract Background SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry....... hiện toàn bộ
Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma
BMC Molecular and Cell Biology - Tập 23 - Trang 1-14 - 2022
Marzia Tagliaferro, Paolo Rosa, Gian Carlo Bellenchi, Daniela Bastianelli, Rosa Trotta, Claudia Tito, Francesco Fazi, Antonella Calogero, Donatella Ponti
The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identified in the nucleus and ...... hiện toàn bộ
Isolation, culture, and characterization of chicken intestinal epithelial cells
BMC Molecular and Cell Biology - - 2021
Federico Ghiselli, Barbara Rossi, Martina Felici, Maria Parigi, Giovanni Tosi, L. Fiorentini, Paola Massi, Andrea Piva, Ester Grilli
Abstract Background Enterocytes exert an absorptive and protective function in the intestine, and they encounter many different challenging factors such as feed, bacteria, and parasites. An intestinal epithelial in vitro model can help to understand how enterocytes are affected by these factors and ...... hiện toàn bộ
CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways
BMC Molecular and Cell Biology -
Wenhu Xin, Jian Zhang, Haibin Zhang, Xiaoxing Ma, Yunzhong Zhang, Yufeng Li, Fang Wang
AbstractCervical cancer is an important malignant tumor threatening the physical and mental health of women in the world. As a new calcium activated chloride channel protein, calcium activated chloride channel (CLCA2) plays an important role in tumorigenesis and development. But its role and exact regulatory mechanism in cervical cancer a...... hiện toàn bộ
Correction to: Binding of Brucella protein, Bp26, to select extracellular matrix molecules
BMC Molecular and Cell Biology - Tập 21 - Trang 1-1 - 2020
Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi, Eugene H. Johnson
Following publication of the original article [1], an error was reported in the tagging of Eugene H. Johnson and Remya R. Nair in the author group.
circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis
BMC Molecular and Cell Biology - Tập 22 - Trang 1-15 - 2021
Xing Zhang, Hongwei Yang, Yingdong Jia, Zhengwen Xu, Liuping Zhang, Meng Sun, Jing Fu
Circular RNAs (circRNAs) are endogenous non-coding RNAs, which are associated with various biological processes, including microRNA (miRNA) interaction, protein binding and regulatory splicing. circRNA_0005529 (circ_0005529) is derived from vacuolar protein sorting 33 homologue B (VPS33B), and its biological role in gastric cancer (GC) has not been examined. In this study, the expression and locat...... hiện toàn bộ
Systemic administration of c-Kit+ cells diminished pulmonary and vascular inflammation in rat model of chronic asthma
BMC Molecular and Cell Biology - Tập 23 - Trang 1-10 - 2022
Sajjad Taghizadeh, Rana Keyhanmanesh, Reza Rahbarghazi, Jafar Rezaie, Aref Delkhosh, Mehdi Hassanpour, Hossein Heiran, Arshad Ghaffari-Nasab, Mahdi Ahmadi
To circumvent some pitfalls related to acute status, chronic model of asthma is conceived to be more suitable approach to guarantee the conditions which are similar to human pulmonary disease. Here, possible therapeutic mechanisms were monitored by which c-kit+ bone marrow cells can attenuate vascular inflammation in rat model of chronic asthma. Data revealed c-Kit+ cells could significantly reduc...... hiện toàn bộ
Differential contribution of p300 and CBP to regulatory element acetylation in mESCs
BMC Molecular and Cell Biology - - 2020
Sara Martire, Jennifer P. Nguyen, Aishwarya Sundaresan, Laura A. Banaszynski
Abstract Background The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters. Although in most cases, CBP and p300 are considered to be functionally identical, both protei...... hiện toàn bộ
MicroRNA-145-5p modulates Krüppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma
BMC Molecular and Cell Biology - - 2022
Chien-Han Yuan, Wei‐Chi Hsu, A‐Mei Huang, Ben-Chih Yuan, I-Hung Chen, Chia-An Hsu, Rong-Feng Chen, Yih-Min Chu, Hui‐Hui Lin, Hung‐Lung Ke
Abstract Background In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinoma (NPC) remains poorly understood. In this study, the association betwe...... hiện toàn bộ
Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes
BMC Molecular and Cell Biology -
Soonho Hwang, Sehee Kim, Kwai Han Yoo, Myung‐Hee Chung, Jin Woo Lee, Kuk Hui Son
AbstractDoxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby DOX induces cardiotoxicity involves pyroptosis through the NLR family pyrin domain containing 3 (NLRP3) inflammasome and gasdermin D (GSDMD). Increased NAPDH oxidase (NOX) and oxidative stress trigger pyroptosis. Exogenous 8-hydroxydeox...... hiện toàn bộ
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