BMC Molecular and Cell Biology
SCIE-ISI SCOPUS (2019-2025)
2661-8850
Cơ quản chủ quản: BMC , BioMed Central Ltd.
Lĩnh vực:
Cell BiologyMolecular Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Differential contribution of p300 and CBP to regulatory element acetylation in mESCs
- 2020
Abstract Background The transcription coactivators CREB binding protein (CBP)
and p300 are highly homologous acetyltransferases that mediate histone 3 lysine
27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters.
Although in most cases, CBP and p300 are considered to be functionally
identical, both proteins are indispensable for development and there is evidence
of tissue...
PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth
Tập 21 Số 1 - 2020
Abstract Background Progesterone Receptor Membrane Component 1 (PGRMC1) is
expressed in many cancer cells, where it is associated with detrimental patient
outcomes. It contains phosphorylated tyrosines which evolutionarily preceded
deuterostome gastrulation and tissue differentiation mechanisms. Results We
demonstrate that manipulating PGRMC1 phosphorylation status in MIA PaCa-2 (MP)
cells imposes...
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches
- 2019
PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease
Tập 21 Số 1 - 2020
Abstract Background Progesterone receptor membrane component 1 (PGRMC1) is often
elevated in cancers, and exists in alternative states of phosphorylation. A
motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently with the
embryological gastrulation organizer that orchestrates vertebrate tissue
differentiation. Results Here, we show that mutagenic manipulation of PGRMC1
phosphorylati...
Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
- 2021
Abstract Background Human induced pluripotent stem cells (iPSC) have opened new
avenues for regenerative medicine. Consequently, iPSC-derived motor neurons have
emerged as potentially viable therapies for spinal cord injuries and
neurodegenerative disorders including Amyotrophic Lateral Sclerosis. However,
direct clinical application of iPSC bears in itself the risk of tumorigenesis
and other unfo...
Isolation, culture, and characterization of chicken intestinal epithelial cells
- 2021
Abstract Background Enterocytes exert an absorptive and protective function in
the intestine, and they encounter many different challenging factors such as
feed, bacteria, and parasites. An intestinal epithelial in vitro model can help
to understand how enterocytes are affected by these factors and contribute to
the development of strategies against pathogens. Results The present study
describes a...
Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines
Tập 21 Số 1 - 2020
Abstract Background Chondrocytes are exposed to an inflammatory
micro-environment in the extracellular matrix (ECM) of articular cartilage in
joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA,
degenerative changes and low-grade inflammation within the joint transform the
behaviour and metabolism of chondrocytes, disturb the balance between ECM
synthesis and degradatio...
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction
Tập 23 Số 1 - 2022
Abstract Background SARS-CoV-2, the causative agent of COVID-19 pandemic is a
RNA virus prone to mutations. Formation of a stable binding interface between
the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and
Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry. RBD
has been shown to mutate frequently during pandemic. Although, a few mutations
in RBD exhibit e...