BMC Molecular and Cell Biology
SCIE-ISI SCOPUS (2019-2023)
2661-8850
Cơ quản chủ quản: BMC , BioMed Central Ltd.
Lĩnh vực:
Cell BiologyMolecular Biology
Các bài báo tiêu biểu
Differential contribution of p300 and CBP to regulatory element acetylation in mESCsAbstract
Background
The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters. Although in most cases, CBP and p300 are considered to be functionally identical, both protei... ...
- 2020
PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growthAbstract
Background
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms.
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Tập 21 Số 1 - 2020
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches
- 2019
PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and diseaseAbstract
Background
Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently with the embryological gastrulation organizer that orchestrates vertebra... ...
Tập 21 Số 1 - 2020
Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiationAbstract
Background
Human induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons have emerged as potentially viable therapies for spinal cord injuries and neurodegenerative disorders including Amyotrophic Lateral Sclerosis. H... ...
- 2021
Isolation, culture, and characterization of chicken intestinal epithelial cellsAbstract
Background
Enterocytes exert an absorptive and protective function in the intestine, and they encounter many different challenging factors such as feed, bacteria, and parasites. An intestinal epithelial in vitro model can help to understand how enterocytes are affected by these factors and ... ...
- 2021
Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokinesAbstract
Background
Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degenerative changes and low-grade inflammation within the joint transform the behaviour and metabolism of ch... ...
Tập 21 Số 1 - 2020
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionAbstract
Background
SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry.... ...
Tập 23 Số 1 - 2022