BMC Immunology
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An increase of CD83+ dendritic cells ex vivo correlates with increased regulatory T cells in patients with active eosinophilic granulomatosis and polyangiitis
BMC Immunology - Tập 15 - Trang 1-12 - 2014
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease characterized by the presence of allergic granulomatosis and necrotizing vasculitis with eosinophilic infiltration. The etiology of EGPA is unknown. Dendritic cells (DCs) are not only critical for the induction of primary immune responses; they may also be important for the induction of immunological tolerance and the regulatio......
NF-κB p50 facilitates neutrophil accumulation during LPS-induced pulmonary inflammation
BMC Immunology - Tập 5 - Trang 1-11 - 2004
Transcription factors have distinct functions in regulating immune responses. During Escherichia coli pneumonia, deficiency of NF-κB p50 increases gene expression and neutrophil recruitment, suggesting that p50 normally limits these innate immune responses. p50-deficient mice were used to determine how p50 regulates responses to a simpler, non-viable bacterial stimulus in the lungs, E. coli lipopo......
Study of membrane potential in T lymphocytes subpopulations using flow cytometry
BMC Immunology - Tập 9 - Trang 1-11 - 2008
Ion channels are involved in the control of membrane potential (ψ) in a variety of cells. The maintenance of ψ in human T lymphocytes is essential for T-cell activation and was suggested to depend mostly on the voltage-gated Kv1.3 channel. Blockage of Kv1.3 inhibits cytokine production and lymphocyte proliferation in vitro and suppresses immune response in vivo. T lymphocytes are a heterogeneous c......
Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients
BMC Immunology - Tập 21 - Trang 1-10 - 2020
Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis of the childhood. However, its mechanisms and pathogenesis still need more exploration. Natural killer (NK) cells are innate lymphocytes, and there is a growing appreciation that cellular metabolism is important in determining the immune responsiveness of lymphocytes. Thus, we aimed to analyze the NK cells phenotype and explore ......
Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection
BMC Immunology - Tập 11 - Trang 1-12 - 2010
Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro. MBL deficiency due to gene polymorphism in humans has been associated with infection susceptibility. These clinical observations were confirmed by animal model studies, in which mice genetically lacking MBL were susceptible to certain pathogens, including herpes simplex virus ......
Long-term humoral and cellular immunity after primary SARS-CoV-2 infection: a 20-month longitudinal study
BMC Immunology - - 2023
SARS-CoV-2 remains a world-wide health issue. SARS-CoV-2-specific immunity is induced upon both infection and vaccination. However, defining the long-term immune trajectory, especially after infection, is limited. In this study, we aimed to further the understanding of long-term SARS-CoV-2-specific immune response after infection. We conducted a longitudinal cohort study among 93 SARS-CoV-2 recove......
SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells
BMC Immunology - Tập 16 - Trang 1-11 - 2015
The innate immune response of urinary tract is critically important in the defense to microbial attack. Toll-like receptor 4 (TLR4) controls initial mucosal response to uropathogenic Escherichia coli (UPEC). However, excessive and dysfunctional TLR signaling may result in severe inflammation and inappropriate tissue damage. Previous studies have demonstrated that single immunoglobulin IL-1R-relate......
Genomic organization and phylogenetic utility of deer mouse (Peromyscus maniculatus) lymphotoxin-alpha and lymphotoxin-beta
BMC Immunology - Tập 9 - Trang 1-10 - 2008
Deer mice (Peromyscus maniculatus) are among the most common mammals in North America and are important reservoirs of several human pathogens, including Sin Nombre hantavirus (SNV). SNV can establish a life-long apathogenic infection in deer mice, which can shed virus in excrement for transmission to humans. Patients that die from hantavirus cardiopulmonary syndrome (HCPS) have been found to expre......
In silico prediction of Ebola Zaire GP1,2 immuno-dominant epitopes for the Balb/c mouse
BMC Immunology - Tập 16 - Trang 1-10 - 2015
Ebola is a Filovirus (FV) that induces a highly communicable and deadly hemorrhagic fever. Currently, there are no approved vaccines to treat FV infections. Protection from FV infection requires cell mediated and humoral immunity. Glycoprotein GP1,2 Fc Zaire, a recombinant FV human Fc fusion protein, has been shown to confer protection against mouse adapted Zaire Ebola virus. The present studies a......
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
BMC Immunology - Tập 10 - Trang 1-11 - 2009
Growing knowledge about cellular interactions in the immune system, including the central role of cytokine networks, has lead to new treatments using monoclonal antibodies that block specific components of the immune system. Systemic cytokine concentrations can serve as surrogate outcome parameters of these interventions to study inflammatory pathways operative in patients in vivo. This is now pos......
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