NF-κB p50 facilitates neutrophil accumulation during LPS-induced pulmonary inflammationBMC Immunology - Tập 5 - Trang 1-11 - 2004
Joseph P Mizgerd, Michal M Lupa, Matt S Spieker
Transcription factors have distinct functions in regulating immune responses. During Escherichia coli pneumonia, deficiency of NF-κB p50 increases gene expression and neutrophil recruitment, suggesting that p50 normally limits these innate immune responses. p50-deficient mice were used to determine how p50 regulates responses to a simpler, non-viable bacterial stimulus in the lungs, E. coli lipopo...... hiện toàn bộ
Study of membrane potential in T lymphocytes subpopulations using flow cytometryBMC Immunology - Tập 9 - Trang 1-11 - 2008
Fernanda Mello de Queiroz, Cristiano G Ponte, Adriana Bonomo, Rosane Vianna-Jorge, Guilherme Suarez-Kurtz
Ion channels are involved in the control of membrane potential (ψ) in a variety of cells. The maintenance of ψ in human T lymphocytes is essential for T-cell activation and was suggested to depend mostly on the voltage-gated Kv1.3 channel. Blockage of Kv1.3 inhibits cytokine production and lymphocyte proliferation in vitro and suppresses immune response in vivo. T lymphocytes are a heterogeneous c...... hiện toàn bộ
Characterization of rag 1 mutant zebrafish leukocytesBMC Immunology - Tập 10 - Trang 1-8 - 2009
Lora Petrie-Hanson, Claudia Hohn, Larry Hanson
Zebrafish may prove to be one of the best vertebrate models for innate immunology. These fish have sophisticated immune components, yet rely heavily on innate immune mechanisms. Thus, the development and characterization of mutant and/or knock out zebrafish are critical to help define immune cell and immune gene functions in the zebrafish model. The use of Severe Combined Immunodeficient (SCID) an...... hiện toàn bộ
Identification and characterization of H-2d restricted CD4+ T cell epitopes on Lpp20 of Helicobacter pyloriBMC Immunology - Tập 13 - Trang 1-8 - 2012
Yan Li, Yin Jiang, Yue Xi, Lili Zhang, Jun Luo, Diandian He, Shuang Zeng, Yunshan Ning
Previous investigation has demonstrated that CD4+ T cells play a crucial role in effective immunity against Helicobacter pylori (H.pylori) infection. It has been well proved that Lpp20 is one of major protective antigens that induce immune responses after H.pylori invades host. Therefore it is valuable to identify CD4+ T cell epitopes on Lpp20, which is uncharacterized. Putative epitopes of H-2d r...... hiện toàn bộ
STAT3 và SPI1 có thể dẫn đến rối loạn hệ thống miễn dịch và phát triển xương dị hợp ở viêm khớp dính khớp Dịch bởi AI BMC Immunology - Tập 23 - Trang 1-14 - 2022
Tuo Liang, Jiarui Chen, GuoYong Xu, Zide Zhang, Jiang Xue, Haopeng Zeng, Jie Jiang, Tianyou Chen, Zhaojie Qin, Hao Li, Zhen Ye, Yunfeng Nie, Xinli Zhan, Chong Liu
Nghiên cứu này nhằm mục tiêu xác định các sinh dấu cho chẩn đoán và tiết lộ những thay đổi trong môi trường vi mô miễn dịch ở viêm khớp dính khớp (AS). Bộ dữ liệu GSE73754 được tải xuống để xây dựng mạng đồng biểu hiện và phân tích tế bào miễn dịch. Phân tích tế bào học dòng chảy được thực hiện để xác nhận kết quả của phân tích bioinformatics. Phân tích làm giàu tập gen (GSEA) được thực hiện để đi...... hiện toàn bộ
#viêm khớp dính khớp #sinh dấu #môi trường vi mô miễn dịch #STAT3 #SPI1 #tế bào miễn dịch
Immune correlates of cardiovascular co-morbidity in HIV infected participants from South IndiaBMC Immunology - Tập 23 - Trang 1-14 - 2022
Bagavathi Kausalya, Shanmugam Saravanan, Suresh Pallikkuth, Rajendra Pahwa, Shelly Rani Saini, Syed Iqbal, Sunil Solomon, Kailapuri G. Murugavel, Selvamuthu Poongulali, Nagalingeswaran Kumarasamy, Savita Pahwa
Understanding the immune correlates of cardiovascular disease (CVD) risk in HIV infection is an important area of investigation in the current era of aging with HIV infection. Less is known about CVD risk and HIV infection in developing nations where additional risk factors may be playing a role in the CVD development. In this study, we assessed the effects of systemic inflammation, microbial tran...... hiện toàn bộ
Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamerBMC Immunology - Tập 20 - Trang 1-10 - 2019
Bonnie J. B. Lewis, Jade Ville, Megan Blacquiere, Selena Cen, Rolf Spirig, Adrian W. Zuercher, Fabian Käsermann, Donald R. Branch
High-dose intravenous immunoglobulin (IVIg), and more recently, subcutaneously-delivered Ig (SCIg), are used to treat a variety of autoimmune diseases; however, there are challenges associated with product production, availability, access and efficacy. These challenges have provided incentives to develop a human recombinant Fc as a more potent alternative to IVIg and SCIg for the treatment of auto...... hiện toàn bộ