BMC Immunology
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Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
BMC Immunology - Tập 9 - Trang 1-8 - 2008
Sand fly saliva contains potent and complex pharmacologic molecules that are able to modulate the host's hemostatic, inflammatory, and immune systems. In this study, we evaluated the effects of salivary gland sonicate (SGS) of Lutzomyia intermedia, the natural vector of Leishmania braziliensis, on monocytes obtained from the peripheral blood mononuclear cells (PBMC) of healthy volunteers. We inves...... hiện toàn bộ
Aquaporin-4 autoantibodies increase vasogenic edema formation and infarct size in a rat stroke model
BMC Immunology - Tập 16 - Trang 1-7 - 2015
Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system, which is characterized by autoantibodies directed against the water channel aquaporin-4 (AQP4). As one of the main water regulators in the central nervous system, APQ4 is supposed to be involved in the dynamics of brain edema. Cerebral edema seriously affects clinical outcome after ischemic stroke; we therefore aim...... hiện toàn bộ
Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in miceAbstract
Background
Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG... ... hiện toàn bộ
BMC Immunology - Tập 22 Số 1
In vitro production of peroxynitrite by haemocytes from marine bivalves: C-ELISA determination of 3-nitrotyrosine level in plasma proteins from Mytilus galloprovincialis and Crassostrea gigas
BMC Immunology - Tập 2 - Trang 1-5 - 2001
Peroxynitrite is increasingly proposed as a contributor to defence system in marine bivalve. It can be formed by combinaison of superoxide and nitric oxide, and can react with tyrosine residues of proteins giving rise to 3-nitrotyrosine. The present article describes a competitive ELISA for the measurement of 3-nitrotyrosine contents of plasma proteins from marine bivalves by means of a monoclonal...... hiện toàn bộ
The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
BMC Immunology - Tập 9 - Trang 1-15 - 2008
The gram-negative bacterium Bordetella pertussis is an important causative agent of pertussis, an infectious disease of the respiratory tract. After introduction of whole-cell vaccines (wP) in the 1950's, pertussis incidence has decreased significantly. Because wP were found to be reactogenic, in most developed countries they have been replaced by acellular vaccines (aP). We have previously shown ...... hiện toàn bộ
Đánh giá cân nặng và chiều cao của bệnh nhân mắc các rối loạn suy giảm miễn dịch nguyên phát và nhóm trẻ em mắc các bệnh nhiễm trùng đường hô hấp tái phát Dịch bởi AI
BMC Immunology - Tập 21 - Trang 1-10 - 2020
Suy giảm miễn dịch nguyên phát (PID) là một nhóm các rối loạn mãn tính nghiêm trọng trong đó phản ứng miễn dịch là không đủ. Do đó, điều này dẫn đến việc tăng nguy cơ mắc các bệnh nhiễm trùng. Tính đến nay, có khoảng 350 rối loạn khác nhau được phân loại trong nhóm này. Cũng có những bệnh nhân bị nhiễm trùng đường hô hấp tái phát (RRTI), tuy nhiên nhóm này không cho thấy bất kỳ bất thường nào liên...... hiện toàn bộ
#suy giảm miễn dịch nguyên phát #trẻ em #điều tra #phát triển thể chất #nhiễm trùng đường hô hấp
Pathogen exposure influences immune parameters around weaning in pigs reared in commercial farmsAbstract
Background
Multiple antigenic stimulations are crucial to immune system training during early post-natal life. These stimulations can be either due to commensals, which accounts for the acquisition and maintenance of tolerance, or to pathogens, which triggers immunity. In pig, only few work... ... hiện toàn bộ
BMC Immunology - Tập 23 Số 1
Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy
BMC Immunology - Tập 23 - Trang 1-12 - 2022
Autophagy is an important mechanism for promoting Mycobacterium clearance from macrophages. Pathogenic and non-pathogenic mycobacterium can activate the mTOR pathway while simultaneously inducing autophagy. M. tuberculosis and M. bovis BCG inhibit autophagy and favor intracellular bacteria survival. We observed that pre-infection of live or heat-killed BCG could prevent autophagy induced by pharma...... hiện toàn bộ
NK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme
BMC Immunology - Tập 20 - Trang 1-9 - 2019
Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intestinal. However, it’s difficult to differ GVHD and its extent just by clinical manifestation. Here we retrospectively analyzed cell immune function in patients implemented allogeneic stem cell t...... hiện toàn bộ
Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
BMC Immunology - Tập 20 - Trang 1-12 - 2019
In this study, seven adjuvants were compared for use with Plasmodium falciparum DiCo-Apical Membrane Antigen 1 (Pf-DiCo-AMA1), with the aim to identify an ideal adjuvant which yields high antibody titres and potentially broadens the responses in clinical trials. The following adjuvant formulations were evaluated: SE, SE-GLA, Liposomes, Liposomes-GLA, CoVaccine HT™, ImSaVac-P and ImSaVac-P o/w. The...... hiện toàn bộ
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