BMC Bioinformatics
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
srnaMapper: an optimal mapping tool for sRNA-Seq reads
BMC Bioinformatics - Tập 23 - Trang 1-19 - 2022
Sequencing is the key method to study the impact of short RNAs, which include
micro RNAs, tRNA-derived RNAs, and piwi-interacting RNA, among others. The first
step to make use of these reads is to map them to a genome. Existing mapping
tools have been developed for long RNAs in mind, and, so far, no tool has been
conceived for short RNAs. However, short RNAs have several distinctive features
which...
RRCRank: a fusion method using rank strategy for residue-residue contact prediction
BMC Bioinformatics - Tập 18 - Trang 1-12 - 2017
In structural biology area, protein residue-residue contacts play a crucial role
in protein structure prediction. Some researchers have found that the predicted
residue-residue contacts could effectively constrain the conformational search
space, which is significant for de novo protein structure prediction. In the
last few decades, related researchers have developed various methods to predict
res...
A new protein-ligand binding sites prediction method based on the integration of protein sequence conservation information
BMC Bioinformatics - Tập 12 - Trang 1-7 - 2011
Prediction of protein-ligand binding sites is an important issue for protein
function annotation and structure-based drug design. Nowadays, although many
computational methods for ligand-binding prediction have been developed, there
is still a demanding to improve the prediction accuracy and efficiency. In
addition, most of these methods are purely geometry-based, if the prediction
methods improve...
Practical application of a Bayesian network approach to poultry epigenetics and stress
BMC Bioinformatics - Tập 23 - Trang 1-16 - 2022
Relationships among genetic or epigenetic features can be explored by learning
probabilistic networks and unravelling the dependencies among a set of given
genetic/epigenetic features. Bayesian networks (BNs) consist of nodes that
represent the variables and arcs that represent the probabilistic relationships
between the variables. However, practical guidance on how to make choices among
the wide ...
libgapmis: extending short-read alignments
BMC Bioinformatics - Tập 14 - Trang 1-14 - 2013
A wide variety of short-read alignment programmes have been published recently
to tackle the problem of mapping millions of short reads to a reference genome,
focusing on different aspects of the procedure such as time and memory
efficiency, sensitivity, and accuracy. These tools allow for a small number of
mismatches in the alignment; however, their ability to allow for gaps varies
greatly, with ...
Identifying microRNA targets in different gene regions
BMC Bioinformatics - Tập 15 - Trang 1-11 - 2014
Currently available microRNA (miRNA) target prediction algorithms require the
presence of a conserved seed match to the 5' end of the miRNA and limit the
target sites to the 3' untranslated regions of mRNAs. However, it has been noted
that these requirements may be too stringent, leading to a substantial number of
missing targets. We have developed TargetS, a novel computational approach for
predi...
Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver
BMC Bioinformatics - Tập 15 Số 1 - 2014
Abstract Background The circadian clock is a critical regulator of biological
functions controlling behavioral, physiological and biochemical processes.
Because the liver is the primary regulator of metabolites within the mammalian
body and the disruption of circadian rhythms in liver is associated with severe
illness, circadian regulators would play a strong role in maintaining liver
function. Ho...
Automatic plankton image classification combining multiple view features via multiple kernel learning
BMC Bioinformatics - Tập 18 - Trang 1-18 - 2017
Plankton, including phytoplankton and zooplankton, are the main source of food
for organisms in the ocean and form the base of marine food chain. As the
fundamental components of marine ecosystems, plankton is very sensitive to
environment changes, and the study of plankton abundance and distribution is
crucial, in order to understand environment changes and protect marine
ecosystems. This study w...
Fold change rank ordering statistics: a new method for detecting differentially expressed genes
BMC Bioinformatics - Tập 15 - Trang 1-15 - 2014
Different methods have been proposed for analyzing differentially expressed (DE)
genes in microarray data. Methods based on statistical tests that incorporate
expression level variability are used more commonly than those based on fold
change (FC). However, FC based results are more reproducible and biologically
relevant. We propose a new method based on fold change rank ordering statistics
(FCROS...
Consolidating metabolite identifiers to enable contextual and multi-platform metabolomics data analysis
BMC Bioinformatics - Tập 11 - Trang 1-11 - 2010
Analysis of data from high-throughput experiments depends on the availability of
well-structured data that describe the assayed biomolecules. Procedures for
obtaining and organizing such meta-data on genes, transcripts and proteins have
been streamlined in many data analysis packages, but are still lacking for
metabolites. Chemical identifiers are notoriously incoherent, encompassing a
wide range ...
Tổng số: 8,323
- 1
- 2
- 3
- 4
- 5
- 6
- 10