Arteriosclerosis, Thrombosis, and Vascular Biology

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eNOS Gene Transfer Inhibits Smooth Muscle Cell Migration and MMP-2 and MMP-9 Activity
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 19 Số 12 - Trang 2871-2877 - 1999
Milind V. Gurjar, Ram V. Sharma, Ramesh C. Bhalla
Abstract —Vascular smooth muscle cell (SMC) migration is a critical step in the development of neointima after angioplasty. Matrix metalloproteinases (MMPs) degrade the basement membrane and the extracellular matrix, facilitating SMC migration. Transfer of the endothelial nitric oxide synthase (eNOS) gene to the injury site inhibits neoin...... hiện toàn bộ
Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 24 Số 7 - Trang 1297-1302 - 2004
Nadine Baroukh, Eric Baugé, Jennifer A. Akiyama, Jessie Chang, Veena Afzal, Jean‐Charles Fruchart, Edward M. Rubin, Jamila Fruchart‐Najib, L Pennacchio
Objective—Both the apolipoprotein A5 and C3 genes have repeatedly been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. In mice, transgenic and knockout experiments indicate that plasma triglyceride levels are strongly altered by changes in the expression of either of these 2 genes. In hu...... hiện toàn bộ
Mutations in Promoter Region of Thrombomodulin and Venous Thromboembolic Disease
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 19 Số 4 - Trang 1098-1104 - 1999
Léna Le Flem, Véronique Picard, Joseph Emmerich, Sophie Gandrille, Jean‐Noël Fiessinger, Martine Aiach, Martine Alhenc‐Gelas
Abstract —The present study was designed to analyze the thrombomodulin proximal promoter region spanning nucleotides −293 to −12 to search for polymorphisms that could modify thrombomodulin gene expression in patients with venous thromboembolic disease. The study population comprised 205 patients and 394 healthy subjects of similar age an...... hiện toàn bộ
Importance of a Novel Oxidative Mechanism for Elimination of Intracellular Cholesterol in Humans
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 16 Số 2 - Trang 208-212 - 1996
Erik Lund, Olof Andersson, Jie Zhang, Amir Babiker, Gunvor Ahlborg, Ulf Diczfalusy, Kurt Einarsson, Jan Sjövall, Ingemar Björkhem
Abstract We have recently demonstrated that cultured human alveolar macrophages efficiently convert cholesterol into excretable 27-oxygenated products. We show here that increasing the intracellular concentration of cholesterol by a factor of 10 leads to about a twofold increase in the excretion of 27-oxygenated products from cultured mac...... hiện toàn bộ
Zinc Finger Transcription Factor Egr-1 Activates Flt-1 Gene Expression in THP-1 Cells on Induction for Macrophage Differentiation
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 20 Số 2 - Trang 377-384 - 2000
Nobuhiro Akuzawa, Masahiko Kurabayashi, Yoshio Ohyama, Masashi Arai, Ryozo Nagai
Abstract —Activation of macrophages is a hallmark of atherosclerosis. Stimulation of human monocytic leukemia THP-1 cells with phorbol 12-myristate 13-acetate (PMA) is known to induce a variety of genes whose function is relevant to activated macrophages. Flt-1, a receptor tyrosine kinase for vascular endothelial growth factor, is express...... hiện toàn bộ
Chlamydia pneumoniae Burden in Carotid Arteries Is Associated With Upregulation of Plaque Interleukin-6 and Elevated C-Reactive Protein in Serum
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 25 Số 12 - Trang 2648-2653 - 2005
S. Claiborne Johnston, Hui Zhang, Louis M. Messina, Michael T. Lawton, Deborah Dean
Objective— Chlamydia pneumoniae (Cpn) infection of vascular smooth muscle cells increases interleukin-6 (IL-6) secretion in vitro. In vivo, IL-6 stimulates liver C-reactive protein (CRP) production. Because serum levels of IL-6 and CRP are independen...... hiện toàn bộ
Fatty Liver
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 28 Số 1 - Trang 27-38 - 2008
Anna Kotronen, Hannele Yki‐Järvinen
Although the epidemic of obesity has been accompanied by an increase in the prevalence of the metabolic syndrome, not all obese develop the syndrome and even lean individuals can be insulin resistant. Both lean and obese insulin resistant individuals have an excess of fat in the liver which is not attributable to alcohol or other known causes of liver disease, a condition defined as nonalc...... hiện toàn bộ
A Variant of Recombinant Factor VIIa With Enhanced Procoagulant and Antifibrinolytic Activities in an In Vitro Model of Hemophilia
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 27 Số 3 - Trang 683-689 - 2007
Geoffrey Allen, Egon Persson, Robert A. Campbell, Mirella Ezban, Ulla Hedner, Alisa S. Wolberg
Objective— Recombinant factor VIIa (rFVIIa, NovoSeven) has proven efficacy in treating bleeding in hemophilia patients with inhibitors. A rFVIIa analog with mutations V158D/E296V/M298Q (NN1731) exhibits increased procoagulant activity in in vitro and in vivo models. The aim of this work w...... hiện toàn bộ
Mechanistic View of Risk Factors for Venous Thromboembolism
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 32 Số 3 - Trang 563-568 - 2012
Pieter H. Reitsma, Henri H. Versteeg, Saskia Middeldorp
Venous thromboembolism is an episodic disease with an annual incidence of 2 to 3/1000 per year that is associated with a high morbidity and mortality. Risk factors for venous thromboembolism come in many guises. They fit into an extended version of Virchow's triad and they tilt the hemostatic balance toward clot formation. This can be achieved by decreasing blood flow and lowering oxygen t...... hiện toàn bộ
Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 19 Số 10 - Trang 2286-2297 - 1999
Paraskevi Andriopoulou, Pilar Navarro, Adriana Zanetti, Maria Grazia Lampugnani, Elisabetta Dejana
Abstract —Endothelial adherens junctions (AJ) promote intercellular adhesion and may contribute to the control of vascular permeability. These structures are formed by a transmembrane and cell-specific adhesive protein, vascular endothelial (VE)-cadherin, which is linked by its cytoplasmic tail to intracellular proteins called catenins (α...... hiện toàn bộ
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