Arteriosclerosis, Thrombosis, and Vascular Biology

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A Comparison of Lupus Anticoagulant–Positive Patients With Clinical Picture of Antiphospholipid Syndrome and Those Without
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 27 Số 12 - 2007
Vittorio Pengo, Alessandra Biasiolo, Paolo Gresele, Francesco Marongiu, Nicoletta Erba, Fabio Veschi, Angelo Ghirarduzzi, Doris Barcellona, Armando Tripodi
eNOS Gene Transfer Inhibits Smooth Muscle Cell Migration and MMP-2 and MMP-9 Activity
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 19 Số 12 - Trang 2871-2877 - 1999
Milind V. Gurjar, Ram V. Sharma, Ramesh C. Bhalla
Abstract —Vascular smooth muscle cell (SMC) migration is a critical step in the development of neointima after angioplasty. Matrix metalloproteinases (MMPs) degrade the basement membrane and the extracellular matrix, facilitating SMC migration. Transfer of the endothelial nitric oxide synthase (eNOS) gene to the injury site inhibits neointima formation. Neither the signaling pathways leading to NO... hiện toàn bộ
Dkk1 and Msx2–Wnt7b Signaling Reciprocally Regulate the Endothelial–Mesenchymal Transition in Aortic Endothelial Cells
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 33 Số 7 - Trang 1679-1689 - 2013
Su‐Li Cheng, Jian-Su Shao, Abraham Behrmann, Karen Krchma, Dwight A. Towler
Objective— Endothelial cells (ECs) can undergo an endothelial–mesenchymal transition with tissue fibrosis. Wnt- and Msx2-regulated signals participate in arteriosclerotic fibrosis and calcification. We studied the impact of Wnt7, Msx2, and Dkk1, a Wnt7 antagonist, on endothelial–mesenchymal transition in primary aortic ECs. Approach and Results— Transduction of aortic ECs with vectors expressing D... hiện toàn bộ
Apolipoprotein AV
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 25 Số 12 - Trang 2445-2447 - 2005
Patrick C.N. Rensen, Ko Willems van Dijk, Louis M. Havekes
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 27 Số 6 - Trang 1417-1425 - 2007
Chao‐Qiang Lai, Donna K. Arnett, Dolores Corella, Robert J. Straka, Michael Y. Tsai, James M. Peacock, Xian Adiconis, Laurence D. Parnell, James E. Hixson, Michael A. Province, José M. Ordovás
Objective— Apolipoprotein A5 ( APOA5 ) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy. Methods and Results— We examined the association between tag SNPs (−1131T>C and 56C>G) at APOA5 and TG and HDL-C response to fenofibrate and a postprandial lipid cha... hiện toàn bộ
Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 24 Số 7 - Trang 1297-1302 - 2004
Nadine Baroukh, Eric Baugé, Jennifer A. Akiyama, Jessie Chang, Veena Afzal, Jean‐Charles Fruchart, Edward M. Rubin, Jamila Fruchart‐Najib, L Pennacchio
Objective—Both the apolipoprotein A5 and C3 genes have repeatedly been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. In mice, transgenic and knockout experiments indicate that plasma triglyceride levels are strongly altered by changes in the expression of either of these 2 genes. In humans, common polymorphisms in both genes have also been as... hiện toàn bộ
Targeted Sequencing Study to Uncover Shared Genetic Susceptibility Between Peripheral Artery Disease and Coronary Heart Disease—Brief Report
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 39 Số 6 - Trang 1227-1233 - 2019
Maya Safarova, Xiao Fan, Erin Austin, Natalie Van Zuydam, Jemma C. Hopewell, Daniel J. Schaid, Iftikhar J. Kullo
Objective— It is unclear to what extent genetic susceptibility variants are shared between peripheral artery disease (PAD) and coronary heart disease (CHD), both manifestations of atherosclerotic vascular disease. We investigated whether common and low-frequency/rare variants in loci associated with CHD are also associated with PAD. Approach and Results— Targeted sequencing of 41 genomic regions a... hiện toàn bộ
Deficiency of Glutathione Peroxidase-1 Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 27 Số 4 - Trang 850-857 - 2007
Michael Torzewski, Viola Ochsenhirt, Andrei L. Kleschyov, Matthias Oelze, Andreas Daiber, Huige Li, Heidi Rossmann, Sotirios Tsimikas, Kurt Reifenberg, Fei Cheng, Hans‐Anton Lehr, Stefan Blankenberg, Thomas Münzel, Karl J. Lackner
Background— We have recently demonstrated that activity of red blood cell glutathione peroxidase-1 is inversely associated with the risk of cardiovascular events in patients with coronary artery disease. The present study analyzed the effect of glutathione peroxidase-1 deficiency on atherogenesis in the apolipoprotein E-deficient mouse. Methods and Results— Female apolipoprotein E-deficient mice w... hiện toàn bộ
Mutations in Promoter Region of Thrombomodulin and Venous Thromboembolic Disease
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 19 Số 4 - Trang 1098-1104 - 1999
Léna Le Flem, Véronique Picard, Joseph Emmerich, Sophie Gandrille, Jean‐Noël Fiessinger, Martine Aiach, Martine Alhenc‐Gelas
Abstract —The present study was designed to analyze the thrombomodulin proximal promoter region spanning nucleotides −293 to −12 to search for polymorphisms that could modify thrombomodulin gene expression in patients with venous thromboembolic disease. The study population comprised 205 patients and 394 healthy subjects of similar age and sex distribution. No polymorphisms and only 1 point mutati... hiện toàn bộ
Importance of a Novel Oxidative Mechanism for Elimination of Intracellular Cholesterol in Humans
Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 16 Số 2 - Trang 208-212 - 1996
Erik Lund, Olof Andersson, Jie Zhang, Amir Babiker, Gunvor Ahlborg, Ulf Diczfalusy, Kurt Einarsson, Jan Sjövall, Ingemar Björkhem
Abstract We have recently demonstrated that cultured human alveolar macrophages efficiently convert cholesterol into excretable 27-oxygenated products. We show here that increasing the intracellular concentration of cholesterol by a factor of 10 leads to about a twofold increase in the excretion of 27-oxygenated products from cultured macrophages. Inhibition of the sterol 27-hydroxylase caused a s... hiện toàn bộ
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