Mechanistic View of Risk Factors for Venous Thromboembolism

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 32 Số 3 - Trang 563-568 - 2012
Pieter H. Reitsma1, Henri H. Versteeg1, Saskia Middeldorp1
1From the Department of Thrombosis and Hemostasis (P.H.R), Einthoven Laboratory for Experimental Vascular Medicine (P.H.R., H.H.V.), and Department of Clinical Oncology (H.H.V.), Leiden University Medical Center, Leiden, the Netherlands; Department of Vascular Medicine (S.M.), Academic Medical Center, Amsterdam, the Netherlands; and Rembrandt Institute of Cardiovascular Science (P.H.R., H.H.V., S.M.), Leiden University Medical Center and the Academic Medical Center, Leiden and Amsterdam, the...

Tóm tắt

Venous thromboembolism is an episodic disease with an annual incidence of 2 to 3/1000 per year that is associated with a high morbidity and mortality. Risk factors for venous thromboembolism come in many guises. They fit into an extended version of Virchow's triad and they tilt the hemostatic balance toward clot formation. This can be achieved by decreasing blood flow and lowering oxygen tension, by activating the endothelium, by activating innate or acquired immune responses, by activating blood platelets, or by increasing the number of platelets and red blood cells or modifying the concentrations of pro- and anticoagulant proteins in the blood. In this narrative review we will discuss the known common risk factors within this pathophysiological framework.

Từ khóa


Tài liệu tham khảo

10.1111/j.1538-7836.2007.02450.x

Virchow R . Thrombose und embolie. Gefässentzündung und septische infektion. Gesammelte Abhandlungen zur wissenschaftlichen Medicin. Frankfurt am Main: Von Meidinger & Sohn. 1856:219–732.

10.1146/annurev-physiol-012110-142305

10.1016/j.cardiores.2006.04.008

10.1182/asheducation-2004.1.439

10.1146/annurev-physiol-042210-121137

10.1073/pnas.0608647104

10.1073/pnas.1005743107

10.1016/j.cell.2009.11.001

10.1001/jama.1983.03330450075032

10.1001/archinte.162.19.2173

10.1001/archinte.158.1.47

10.1111/j.1538-7836.2010.03819.x

10.1055/s-0031-1297369

10.1111/j.1471-0528.1997.tb11043.x

10.1002/ajh.21059

10.1016/S0140-6736(06)68474-2

10.1186/1741-7015-9-1

10.1016/S0140-6736(10)60709-X

Lorenzet R, Napoleone E, Cutrone A, Donati MB . Thrombosis and obesity: cellular bases. Thromb Res. 2011.

10.1161/atvbaha.107.140384

10.1016/j.ajhg.2010.02.011

10.1371/journal.pmed.0030334

10.1136/jcp.s3-4.1.86

10.1111/j.1538-7933.2004.00618.x

10.1001/jama.299.11.1306

10.1016/j.blre.2007.11.001

10.1160/TH08-05-0314

10.1055/s-2007-976165

10.1007/s00277-011-1233-0

10.1056/NEJMp038177

Vaya A, Mira Y, Martinez M, Villa P, Ferrando F, Estelles A, Corella D, Aznar J . Biological risk factors for deep vein trombosis. Clin Hemorheol Microcirc. 2002; 26: 41– 53 .

10.1001/archinte.162.10.1182

10.3324/haematol.2009.008417

10.3324/haematol.2009.017285

10.1161/CIRCRESAHA.110.233056

10.1213/ane.0b013e31819bceb1

10.1055/s-0037-1615646

10.1084/jem.20061302

10.1160/TH09-09-0633

Ye R, Ye C, Huang Y, Kiu L, Wang S . Circulating tissue factor positive microparticles in patients with acute recurrent deep venous thrombosis. Thromb Res. 2011.

10.1111/j.1538-7836.2011.04488.x

10.1016/j.thromres.2005.01.013

10.1024/0301-1526/a000081

10.1016/j.thromres.2010.07.006

10.1016/j.thromres.2009.09.019

10.1111/j.1538-7836.2008.02963.x

10.1111/j.1538-7836.2007.02369.x

10.1111/j.1538-7836.2009.03504.x

10.1158/1078-0432.CCR-09-0371

10.1007/s11060-010-0462-8

10.1084/jem.20082297

10.1159/000324166

10.1161/01.CIR.96.10.3534

10.1111/j.1538-7836.2009.03394.x

10.1182/blood.V78.4.890.890

10.1056/NEJMoa0810739

10.1055/s-0037-1615049

10.1111/j.1538-7836.2004.01071.x

10.1182/blood-2005-05-2180

10.1055/s-0037-1613958

10.1055/s-0037-1613960

10.1055/s-0037-1613959

10.1055/s-0038-1653788

10.1111/j.1538-7836.2008.02863.x

10.1016/S0140-6736(99)06092-4

10.1111/j.1538-7836.2004.00983.x

10.1111/j.1538-7836.2010.04148.x

10.1160/TH06-11-0632

10.1016/j.thromres.2006.10.013

10.1080/13697130701624773

10.1097/gme.0b013e318093e65a

10.1136/bmj.39555.441944.BE

10.1016/j.thromres.2004.08.004

10.1055/s-0037-1613379

10.1046/j.1467-789X.2002.00056.x

10.1160/TH03-01-0014

10.1210/jc.2004-1292

10.1016/j.thromres.2008.07.017

10.1111/j.1538-7836.2010.03766.x

10.1161/01.ATV.13.2.162

Thông tin
Thông tin xuất bản

Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 32 Số 3

563-568

Thông tin tác giả