Archives of Pharmacal Research

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No role of protected region b of human cytochrome P4501A2 gene (CYP1A2) as an AP-1 response element
Archives of Pharmacal Research - Tập 25 - Trang 375-380 - 2002
Injae Chung, Kihwa Jung
Cytochrome P4501A2 (CYP1A2) is a member of the cytochrome P450 family of isozymes involved in the phase I drug metabolism of vertebrates. CYP1A2 is responsible for the activation of a number of aromatic amines to mutagenic and carcinogenic forms. Thus, the level of CYP1A2, which varies among different populations, may determine an individual's susceptibility to these chemicals. We have previously ...... hiện toàn bộ
Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus
Archives of Pharmacal Research - Tập 37 - Trang 1117-1123 - 2014
Shu-Jen Chang, Su-Hua Huang, Ying-Ju Lin, Yi-Yun Tsou, Cheng-Wen Lin
Rheum palmatum, Chinese traditional herb, exhibits a great variety of anti-cancer and anti-viruses properties. This study rates antiviral activity of R. palmatum extracts and its components against Japanese encephalitis virus (JEV) in vitro. Methanol extract of R. palmatum contained higher levels of aloe emodin, chrysophanol, rhein, emodin and physcion than water extract. Methanol...... hiện toàn bộ
Pharmacokinetic characterization of CK2 inhibitor CX-4945
Archives of Pharmacal Research - Tập 36 - Trang 840-845 - 2013
You Hwa Son, Jin Sook Song, Seong Hwan Kim, Jiyeon Kim
Over-expression of protein kinase CK2 is highly linked to the survival of cancer cells and the poor prognosis of patients with cancers. CX-4945, a potent and selective orally bioavailable ATP-competitive inhibitor of CK2, inhibits the oncogenic cellular events such as proliferation and angiogenesis, and the increase of tumor growth in mouse xenograft model. In this study, the pharmacokinetic infor...... hiện toàn bộ
Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis
Archives of Pharmacal Research - Tập 33 Số 10 - Trang 1567-1574 - 2010
Chang-Wook Lee, Ji Woong Choi, Jerold Chun
Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
Archives of Pharmacal Research - Tập 39 - Trang 1503-1518 - 2016
Je-Wook Yu, Myung-Shik Lee
The NLRP3 inflammasome is assembled and activated in certain types of myeloid cells upon sensing microbe-derived toxins or host-derived danger signals. Activation of the NLRP3 inflammasome by endogenous ligands has been discovered in various disorders, including metabolic syndrome, type 2 diabetes, atherosclerosis, gout, reperfusion injury of the heart, neurodegeneration, such as Alzheimer’s disea...... hiện toàn bộ
Anti-allergic components from the peels ofCitrus unshiu
Archives of Pharmacal Research - Tập 22 - Trang 642-645 - 1999
Dae Keun Kim, Ki Taek Lee, Jae Soon Eun, Ok Pyo Zee, Jong Pil Lim, Sang Sup Eum, Sang Hyun Kim, Tae Yong Shin
In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, polymethoxyflavones, 3′,4′,5,6,7,8-hexamethoxyflavone (I), 5-hydroxy-3′,4′,6,7,8-pentamethoxyflavone (II) and 3′,4′,5,7,8,-pentamethoxyflavone (III) have been isolated from the immature peels ofCitrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. CompoundsI andII i...... hiện toàn bộ
Norlignan derivatives from Curculigo crassifolia and their DPPH radical scavenging activity
Archives of Pharmacal Research - Tập 31 - Trang 1313-1316 - 2008
Kai-Jin Wang, Ning Li
A novel norlignan derivative, crassifogenin C (1), and a known compound, curcapital (2), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Curcapital (2) was isolated from this plant for the first time. The free radical scavenging activity of the isolated c...... hiện toàn bộ
Determination of ampicillin and cloxacillin mixture by NMR
Archives of Pharmacal Research - Tập 4 - Trang 9-17 - 1981
Moon-Hee Shin, Man-Ki Park, Chang-Hwa Yu, Jung-Kap Choi
A simple, accurate and specific NMR procedure is described for the determination of ampicillin and cloxacillin mixtures in injection dosage form and capsules. The solvent was dimethylsulfoxde-d6 and maleic acid was the internal standard. By integrating the peak at 2.68 ppm and 4.57 ppm, cloxacillin and ampicillin could be determined respectively. The relative proton ratio of ampicillin trihydrate ...... hiện toàn bộ
Current status of anti-HBV chemotherapy
Archives of Pharmacal Research - - 1998
Joon Hee Hong, Yongseok Choi, Byoung K. Chun, Kyeong Lee, Chung K. Chu
Pharmacological activities and the constituents of the leaves ofHedera rhombea Bean (II): On the constituents of the leaves
Archives of Pharmacal Research - Tập 16 - Trang 331-335 - 1993
Ihn Rhan Lee, Min Suk Lee, Kyoung Ah Choi, Eun Kyoung Seo
Three phenolic compounds and a dammarane glycoside were isolated from the leaves ofHedera rhombea Bean (Araliaceae). Their structures were characterized as rutin, caffeic acid, 3,5-dicaffeoyl quinic acid and Kizuta saponin K5 by chemical and spectral analysis.
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