Archives of Pharmacal Research

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A novel in vitro ischemia/reperfusion injury model
Archives of Pharmacal Research - Tập 32 - Trang 421-429 - 2009
Won Hee Lee, Sungkwon Kang, Pavlos P. Vlachos, Yong Woo Lee
The reperfusion of blood flow occurred in a number of conditions such as stroke and organ transplantation immensely augments tissue injury and causes more severe damage than prolonged ischemia. In the present study, we designed a novel double-layer parallel-plate flow chamber (PPFC) to develop an in vitro ischemia/reperfusion (I/R) injury model and examined the effects of I/R on inflammatory respo...... hiện toàn bộ
Protective effects of α-tocopherol and ischemic preconditioning on hepatic reperfusion injury
Archives of Pharmacal Research - Tập 28 - Trang 1392-1399 - 2005
Woo-Yong Lee, Sun Lee
This study evaluated the effect of α-tocopherol (α-TC), íschemic preconditioning (IPC) or combination on the extent of mitochondrial injury caused by hepatic ischemia/reperfusion (I/R). Rats were pretreated with α-TC (20 mg/kg per day, i.p.) for 3 days before sustained ischemia. A rat liver was preconditioned with 10 min of ischemia and 10 min of reperfusion, and was then subjected to 90 min of is...... hiện toàn bộ
Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells
Archives of Pharmacal Research - Tập 37 Số 4 - Trang 452-458 - 2014
Chaewon Kim, Saet‐Byeul Kim, Myung‐Sook Park
Targeting ROCK/LIMK/cofilin signaling pathway in cancer
Archives of Pharmacal Research - Tập 42 - Trang 481-491 - 2019
Mee-Hyun Lee, Joydeb Kumar Kundu, Jung-Il Chae, Jung-Hyun Shim
Rho-associated coiled-coil-containing protein kinase (ROCK)/Lin11, Isl-1 and Mec-3 kinase (LIMK)/cofilin-signaling cascades are stimulated by receptor tyrosine kinases, G protein-coupled receptors, integrins and its ligands, growth factors, hormones, fibronectin, collagen, and laminin. Activated signaling cascades can cause transit from normal cells to cancer cells by modulating actin/filament dyn...... hiện toàn bộ
Cytotoxic isoquinoline alkaloids from the aerial parts ofCorydalis incisa
Archives of Pharmacal Research - Tập 30 - Trang 151-154 - 2007
Sang Un Choi, Nam-ln Baek, Sung-Hoon Kim, Jae Heon Yang, Jae Soon Eun, Tae Yong Shin, Jong Pil Lim, Jae Hyeok Lee, Hoon Jeon, Mi-Young Yun, Kang-Hyun Leem, Hee Wook Park, Dae Keun Kim
Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts ofCorydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV...... hiện toàn bộ
Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo
Archives of Pharmacal Research - Tập 34 Số 12 - Trang 2087-2099 - 2011
Hyun Ah Jung, Seong Eun Jin, Ran Joo Choi, Hung Tran Manh, Yeong Shik Kim, Byung‐Sun Min, You Kyung Son, Bo Ra Ahn, Byung-Woo Kim, Hee Sook Sohn, Jae Sue Choi
Hepatoprotective activity of scopoletin, a constituent ofSolanum lyratum
Archives of Pharmacal Research - - 1998
So Young Kang, Sang Hyun Sung, Jong Hee Park, Young Choong Kim
Changes in the central dopaminergic systems in the streptozotocin-induced diabetic rats
Archives of Pharmacal Research - Tập 17 - Trang 398-404 - 1994
D. K. Lim, K. M. Lee, I. K. Ho
The behavioral response, dopamine metabolism, and characteristics of dopamine subtypes after developing the hyperglycemia were studied in the striata of rats. In animals developed hyperglycemia, the on-set and duration of cataleptic behavior responded to SCH 23390 injection was delayed and shortened, respectively. However, the cataleptic responses to spiperone occurred significantly earlier in on-...... hiện toàn bộ
Differential effects of quercetin glycosides on GABAC receptor channel activity
Archives of Pharmacal Research - Tập 38 - Trang 108-114 - 2014
Hyeon-Joong Kim, Byung-Hwan Lee, Sun-Hye Choi, Seok-Won Jung, Hyun-Sook Kim, Joon-Hee Lee, Sung-Hee Hwang, Mi-Kyung Pyo, Hyoung-Chun Kim, Seung-Yeol Nah
Quercetin, a representative flavonoid, is a compound of low molecular weight found in various colored plants and vegetables. Quercetin shows a wide range of neuropharmacological activities. In fact, quercetin naturally exists as monomer-(quercetin-3-O-rhamnoside) (Rham1), dimer-(Rutin), or trimer-glycosides [quercetin-3-(2G-rhamnosylrutinoside)] (Rham2) at carbon-3 in fruits and vegetables. The ca...... hiện toàn bộ
Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin
Archives of Pharmacal Research - Tập 38 Số 5 - Trang 620-627 - 2015
Hyun Jae Lee, Jiho Ryu, Sang Hyoung Park, Eun Kyoung Seo, Ah Reum Han, Sang Kook Lee, Yeong Shik Kim, Jang Hee Hong, Jeong Ho Seok, Choong Jae Lee
Tổng số: 3,741   
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