Archives of Pharmacal Research

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A new phenolic compound with anticancer activity from the wood of Millettia leucantha
Archives of Pharmacal Research - Tập 34 - Trang 881-886 - 2011
Kanok-on Rayanil, Pastraporn Bunchornmaspan, Pittaya Tuntiwachwuttikul
A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol (1), along with six known compounds, medicarpin (2), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (3), 5,4′-dihydroxy-7,8-dimethoxyisoflavone (4), physcion (5), (R)-(-)-mellein (6) and isoliquiritigenin (7), were isolated from the wood of Millettia leucantha. The structur...... hiện toàn bộ
Inhibitory effect of Kyungohkgo in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice
Archives of Pharmacal Research - Tập 34 - Trang 317-321 - 2011
Lee-Rang Im, Ji-Young Ahn, Jun-Ho Kim, Mingjie Xin, Se-Uk Kwon, Yun-Kyung Kim, Dae-Ki Kim, Young-Mi Lee
Kyungohkgo (KOG) is one of the most important formulas in traditional oriental medicine. We investigated the remedial effect of KOG on the development of atopic dermatitis (AD) in female NC/Nga mice. AD-like lesion was induced by the application of 2,4-Dinitrochlorobenzene on to the back skin repeatedly; KOG was administered orally (12.5 and 25.0 mg/kg) and topically (0.5 and 1.0 mg/mouse) to NC/N...... hiện toàn bộ
Synthesis and pharmacological evaluation of [(4-arylpiperazin-1-yl)-alkyl]-carbamic acid ethyl ester derivatives as potential anxiolytic agents
Archives of Pharmacal Research - Tập 35 - Trang 1143-1152 - 2012
Manisha Khatri, Santosh K. Rai, Ranjit Ranbhor, Krishna Kishore, Manisha Tiwari
On the basis of our earlier studies, a series of N-{4-[4-(aryl) piperazin-1-yl]-phenyl}-amine derivatives containing terminal carbamoyl fragment with alkyl spacer of different lengths (15–20) were synthesized as ligands, for 5-hydroxytryptamine-1A (5-HT1A) receptor. Molecular modeling studies were undertaken to explain the influence of spacer length on ligands affinity towards 5-HT1A receptor. Com...... hiện toàn bộ
Design, synthesis, in vitro cytotoxicity evaluation and structure–activity relationship of Goniothalamin analogs
Archives of Pharmacal Research - Tập 36 - Trang 812-831 - 2013
Mazlin Mohideen, Suraya Zulkepli, Nik-Salmah Nik-Salleh, Mohd Zulkefeli, Jean-Frédéric Faizal Abdullah Weber, A. F. M. Motiur Rahman
A series of six/five member (E/Z)-Goniothalamin analogs were synthesized from commercially available (3,4-dihydro-2H-pyran-2-yl)methanol/5-(hydroxymethyl)dihydrofuran-2(3H)-one in three steps with good to moderate overall yields and their cytotoxicity against lymphoblastic leukemic T cell line (Jurkat E6.1) have been evaluated. Among the synthesized analogs, (Z)-Goniothalamin appeared to be the mo...... hiện toàn bộ
Possible role of arginase 1 positive microglia on depressive/anxiety-like behaviors in atopic dermatitis mouse model
Archives of Pharmacal Research - Tập 45 - Trang 11-28 - 2022
Bohyun Yang, Jae-Sang Ryu, Chan Rim, Jung U. Shin, Min-Soo Kwon
Atopic dermatitis (AD) and mood disorder comorbidities are typical, but the exact mechanism underlying their interplay has not been clarified. In this study, we aimed to identify the possible mechanisms of anxiety/depressive-like behaviors observed in AD, focusing on microglia. AD was induced by Dermatophagoides farinae body extract (Dfb) in NC/Nga mice and anxiety/depressive-like behaviors were a...... hiện toàn bộ
Synthesis of β-hydroxy-propenamide derivatives and the inhibition of human dihydroorotate dehydrogenase
Archives of Pharmacal Research - Tập 26 - Trang 197-201 - 2003
Taek Hyeon Kim, Hye -Sun Na, Monika Löffler
Novel β-hydroxy propenamides as analogues of the active metabolite of leflunomide (A 771726) were synthesized and evaluated for their inhibitory activity on dihydroorotate dehydrogenase (DHODH) in an investigation into their immunosuppressive activity. Compounds2a, 3a, and3h were approximately 4–40 times more potent than leflunomide in their activity while they wereless active than A 771726.
Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects
Archives of Pharmacal Research - Tập 30 Số 3 - Trang 282-289 - 2007
Jeong, Byeong-Seon, Lee, Mi Kyeong, Kim, Young Choong, Lee, Eung-Seok
For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their hepatoprotective effects. Among prepared compounds, com-pounds10 and14 showed better hepatoprotective effects compared to Silymarin.
Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus
Archives of Pharmacal Research - Tập 35 Số 9 - Trang 1673-1683 - 2012
Mi Jeong Heo, Ok Sang Lee, Sung Cil Lim
Bovine lens aldose reductase inhibitory effects of some natural monoterpenes
Archives of Pharmacal Research - - 1985
Chang Kiu Moon, Yong Soo Yun, Jong‐Seok Lim, Chong Kul Ryu
Lignans from Saururus chinensis exhibit anti-inflammatory activity by influencing the Nrf2/HO-1 activation pathway
Archives of Pharmacal Research - Tập 42 - Trang 332-343 - 2019
Yeon Woo Jung, Bo Mi Lee, Manh Tuan Ha, Manh Hung Tran, Jeong Ah Kim, Suhyun Lee, Jeong Hyung Lee, Mi Hee Woo, Byung Sun Min
As part of our ongoing program to develop anti-inflammatory agents, an extract derived from Saururus chinensis collected in Korea was found to inhibit nitric oxide (NO) production in RAW264.7 cells. Bioassay-guided fractionation led to the isolation two new (1 and 2) and six known dineolignans (3–8). To the best of our knowledge, manassatin B1 (3) was isolated from S. chinensis for the first time....... hiện toàn bộ
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