Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation Tập 10 Số 10 - Trang 753-768 - 2010
Carlos Mas‐Moruno, Florian Rechenmacher, Horst Kessler
Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for treatment of glioblastomas and in phase II for several other tumors. This drug is the first anti-angiogenic small molecule targeting the integrins αvβ3, αvβ5 and α5β1. It was developed by us in the early 90s by a novel procedure, the spatial screening. This strategy resulted in c(RGDf...... hiện toàn bộ
Silibinin – A Promising New Treatment for Cancer Tập 10 Số 3 - Trang 186-195 - 2010
Catherine Cheung, Norma Gibbons, David W. Johnson, David L. Nicol
Silymarin and its major constituent, Silibinin, are extracts from the medicinal plant Silybum marianum (milk thistle) and have traditionally been used for the treatment of liver diseases. Recently, these orally active, flavonoid agents have also been shown to exert significant anti-neoplastic effects in a variety of in vitro and in vivo cancer models, including ...... hiện toàn bộ
Urea Derivatives as Anticancer Agents Tập 9 Số 4 - Trang 471-480 - 2009
Huan‐Qiu Li, Peng‐Cheng Lv, Tao Yan, Hai‐Liang Zhu
Within the past ten years, a huge volume of research on the synthesis, structure-activity relationships (SAR), and anticancer activities of the urea derivatives was reported. Many aromatic urea derivatives such as N-phenyl-N-(2-chloroethyl)ureas (CEUs) and benzoylureas (BUs) show good anticancer activity, and these compounds have mainly been proved to be tubulin...... hiện toàn bộ
Marine Peptides and Related Compounds in Clinical Trial+ Tập 6 Số 1 - Trang 33-40 - 2006
Diwan S. Rawat, Mukesh C. Joshi, Penny Joshi, Himanshu Atheaya
Advances in the sophisticated instruments for the isolation and characterization of marine natural products, and development in the biological assay systems, have resulted in the discovery of various compounds of biomedical application. Marine natural products have been a source of new leads for the treatment of many deadly diseases such as cancer, acquired immu...... hiện toàn bộ