Anti-Cancer Agents in Medicinal Chemistry
SCIE-ISI SCOPUS (2006-2025)
1871-5206
1875-5992
Các Tiểu vuơng quốc Ả Rập Thống nhất
Cơ quản chủ quản: Bentham Science Publishers B.V. , BENTHAM SCIENCE PUBL LTD
Lĩnh vực:
PharmacologyMolecular MedicineCancer Research
Các bài báo tiêu biểu
Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
Tập 10 Số 10 - Trang 753-768 - 2010
Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for
treatment of glioblastomas and in phase II for several other tumors. This drug
is the first anti-angiogenic small molecule targeting the integrins αvβ3, αvβ5
and α5β1. It was developed by us in the early 90s by a novel procedure, the
spatial screening. This strategy resulted in c(RGDfV), the first superactive
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Silibinin – A Promising New Treatment for Cancer
Tập 10 Số 3 - Trang 186-195 - 2010
Silymarin and its major constituent, Silibinin, are extracts from the medicinal
plant Silybum marianum (milk thistle) and have traditionally been used for the
treatment of liver diseases. Recently, these orally active, flavonoid agents
have also been shown to exert significant anti-neoplastic effects in a variety
of in vitro and in vivo cancer models, including skin, breast, lung, colon,
bladder, ...
Discovery of Small Molecule c-Met Inhibitors: Evolution and Profiles of Clinical Candidates
Tập 10 Số 1 - Trang 7-27 - 2010
Urea Derivatives as Anticancer Agents
Tập 9 Số 4 - Trang 471-480 - 2009
Within the past ten years, a huge volume of research on the synthesis,
structure-activity relationships (SAR), and anticancer activities of the urea
derivatives was reported. Many aromatic urea derivatives such as
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Can We Effectively Degrade Microcystins? - Implications on Human Health
Tập 11 Số 1 - Trang 19-37 - 2011
Astemizole: an Old Anti-histamine as a New Promising Anti-cancer Drug
Tập 11 Số 3 - Trang 307-314 - 2011
Marine Peptides and Related Compounds in Clinical Trial+
Tập 6 Số 1 - Trang 33-40 - 2006
Advances in the sophisticated instruments for the isolation and characterization
of marine natural products, and development in the biological assay systems,
have resulted in the discovery of various compounds of biomedical application.
Marine natural products have been a source of new leads for the treatment of
many deadly diseases such as cancer, acquired immuno-deficiency syndrome (AIDS)
etc. T...