Phosphate Transporters and Their FunctionAnnual Review of Physiology - Tập 75 Số 1 - Trang 535-550 - 2013
Jürg Biber, Nati Hernando, Ian C. Forster
Plasma phosphate concentration is maintained within a relatively narrow range by control of renal reabsorption of filtered inorganic phosphate (Pi). Pi reabsorption is a transcellular process that occurs along the proximal tubule. Pi flux at the apical (luminal) brush border membrane represents the rate-limiting step and is me...... hiện toàn bộ
Lysosomal PhysiologyAnnual Review of Physiology - Tập 77 Số 1 - Trang 57-80 - 2015
Haoxing Xu, Dejian Ren
Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking. Lysosomes also contain more than 50 membrane prot...... hiện toàn bộ
Complementary Roles of the Main and Accessory Olfactory Systems in Mammalian Mate RecognitionAnnual Review of Physiology - Tập 71 Số 1 - Trang 141-160 - 2009
Michael J. Baum, Kevin R. Kelliher
We review studies conducted in mouse and ferret that have specified roles of both the main and the accessory olfactory nervous systems in the detection and processing of body odorants (e.g., urinary pheromones, extraorbital lacrimal gland secretions, major histocompatibility complex peptide ligands, and anal scent gland secretions) that play an essential role in sex discrimination and att...... hiện toàn bộ
Evolution and Physiological Roles of Phosphagen SystemsAnnual Review of Physiology - Tập 63 Số 1 - Trang 289-325 - 2001
W. Ross Ellington
▪ Abstract Phosphagens are phosphorylated guanidino compounds that are linked to energy state and ATP hydrolysis by corresponding phosphagen kinase reactions: phosphagen + MgADP + H+↔ guanidine acceptor + MgATP. Eight different phosphagens (and corresponding phosphagen kinases) are found in the animal kingdom distributed along distinct phylogenetic lines. By far, the ...... hiện toàn bộ
Resurgence of Sodium Channel ResearchAnnual Review of Physiology - Tập 63 Số 1 - Trang 871-894 - 2001
Alan L. Goldin
▪ Abstract A variety of isoforms of mammalian voltage-gated sodium channels have been described. Ten genes encoding sodium channel α subunits have been identified, and nine of those isoforms have been functionally expressed in exogenous systems. The α subunit is associated with accessory β subunits in some tissues, and three genes encoding different β subunits have been identified. The α...... hiện toàn bộ
Nuclear Receptors and the Control of MetabolismAnnual Review of Physiology - Tập 65 Số 1 - Trang 261-311 - 2003
Gordon A. Francis, Elisabeth Fayard, Frédéric Picard, Johan Auwerx
▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling the organism to quickly adapt to environmental changes by inducing the appropriate metabolic genes and pathways. Ligands for these metabolic receptors are compounds from dietary origin, intermediates in metabolic pathways, drugs, or other environmental factors that, unlike classical nuclear rec...... hiện toàn bộ