Annual Review of Physiology
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Hypoxia Tolerance in Mammals and Birds: From the Wilderness to the ClinicAll mammals and birds must develop effective strategies to cope with reduced oxygen availability. These animals achieve tolerance to acute and chronic hypoxia by (a) reductions in metabolism, (b) the prevention of cellular injury, and (c) the maintenance of functional integrity. Failure to meet any one of these tasks is detrimental. Birds and mammals accomplish this triple task through a h... ... hiện toàn bộ
Annual Review of Physiology - Tập 69 Số 1 - Trang 113-143 - 2007
Receptor-Mediated Endocytosis of Hormones in Cultured Cells
Annual Review of Physiology - Tập 43 Số 1 - Trang 239-250 - 1981
Intestinal Synthesis, Secretion, and Transport of Lipoproteins
Annual Review of Physiology - Tập 45 Số 1 - Trang 625-636 - 1983
The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic DisordersMitochondrial fatty acid β-oxidation (FAO) is the major pathway for the degradation of fatty acids and is essential for maintaining energy homeostasis in the human body. Fatty acids are a crucial energy source in the postabsorptive and fasted states when glucose supply is limiting. But even when glucose is abundantly available, FAO is a main energy source for the heart, skeletal muscle, an... ... hiện toàn bộ
Annual Review of Physiology - Tập 78 Số 1 - Trang 23-44 - 2016
Central Mechanisms for ThermoregulationMaintenance of a homeostatic body core temperature is a critical brain function accomplished by a central neural network. This orchestrates a complex behavioral and autonomic repertoire in response to environmental temperature challenges or declining energy homeostasis and in support of immune responses and many behavioral states. This review summarizes the anatomical, neurotransmitter, an... ... hiện toàn bộ
Annual Review of Physiology - Tập 81 Số 1 - Trang 285-308 - 2019
The Physiological Significance of the Cardiotonic Steroid/Ouabain-Binding Site of the Na,K-ATPase The Na,K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across the plasma membrane that drives many physiological processes. This enzyme is highly sensitive to inhibition by cardiotonic steroids, most notably the digitalis/ouabain class of compounds, which have been used for centuries to treat congestive heart failure and ar... ... hiện toàn bộ
Annual Review of Physiology - Tập 72 Số 1 - Trang 395-412 - 2010
Regulation of TRP Channels via Lipid Second Messengers ▪ Abstract In Drosophila photoreceptors, the light-sensitive current is mediated downstream of phospholipase C by TRP (transient receptor potential) channels. Recent evidence suggests that Drosophila TRP channels are activated by diacylglycerol (DAG) or its metabolites (polyunsaturated fatty acids), possibly in combination with the reduction in phosphatidyl inositol 4,5 bisphosphate (PIP... ... hiện toàn bộ
Annual Review of Physiology - Tập 65 Số 1 - Trang 735-759 - 2003
Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms Vesicle exocytosis releases content to mediate many biological events, including synaptic transmission essential for brain functions. Following exocytosis, endocytosis is initiated to retrieve exocytosed vesicles within seconds to minutes. Decades of studies in secretory cells reveal three exocytosis modes coupled to three endocytosis modes: (a) full-collapse fusion, in which vesicles col... ... hiện toàn bộ
Annual Review of Physiology - Tập 76 Số 1 - Trang 301-331 - 2014
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