Annual Review of Pharmacology and Toxicology

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CYTOCHROME P-450 3A4: Regulation and Role in Drug Metabolism
Annual Review of Pharmacology and Toxicology - Tập 39 Số 1 - Trang 1-17 - 1999
F. Peter Guengerich
▪ Abstract  Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues of bioavailability and drug-drug interactions. The gene is known to be inducible by barbiturates, glucocorticoids, and rifampi...... hiện toàn bộ
LPA Receptors: Subtypes and Biological Actions
Annual Review of Pharmacology and Toxicology - Tập 50 Số 1 - Trang 157-186 - 2010
Ji Woong Choi, Deron R. Herr, Kyoko Noguchi, Yun C. Yung, Chang‐Wook Lee, Tetsuji Mutoh, Mu‐En Lin, Siew T. Teo, Kristine E. Park, Alycia Mosley Austin, Jerold Chun
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signaling molecule by binding to and activating at least five known G protein–coupled receptors (GPCRs): LPA1–LPA5. They are encoded by distinct genes named LPAR1–LPAR5 in humans and Lpar1–Lpar5 in mice. The biological roles of LPA are diverse and include ...... hiện toàn bộ
GLUTATHIONE TRANSFERASES
Annual Review of Pharmacology and Toxicology - Tập 45 Số 1 - Trang 51-88 - 2005
John D. Hayes, Jack U. Flanagan, Ian R. Jowsey
▪ Abstract  This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG. Besides detoxifying electrophilic xenobiotics, such as chemical carcinogens, environmental pollutants, and antitumor agents, these transferases inactivate endogenous α,β-unsaturated aldehydes, quinones, epoxides...... hiện toàn bộ
Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders
Annual Review of Pharmacology and Toxicology - Tập 60 Số 1 - Trang 591-614 - 2020
Zhi‐De Deng, Bruce Luber, Nicholas L. Balderston, Melbaliz Velez Afanador, Michelle M. Noh, Jeena Thomas, William Altekruse, Shannon Exley, Shriya Awasthi, Sarah H. Lisanby
Device-based neuromodulation of brain circuits is emerging as a promising new approach in the study and treatment of psychiatric disorders. This work presents recent advances in the development of tools for identifying neurocircuits as therapeutic targets and in tools for modulating neurocircuits. We review clinical evidence for the therapeutic efficacy of circuit modulation with a range ...... hiện toàn bộ
Cholecystokinin Antagonists
Annual Review of Pharmacology and Toxicology - Tập 31 Số 1 - Trang 469-501 - 1991
G.N. Woodruff, Joel W. Hughes
Mitochondrial Benzodiazepine Receptors and the Regulation of Steroid Biosynthesis
Annual Review of Pharmacology and Toxicology - Tập 32 Số 1 - Trang 211-237 - 1992
Karl E. Krueger, Vasileios Papadopoulos
INHIBITION OF NITRIC OXIDE SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET
Annual Review of Pharmacology and Toxicology - Tập 39 Số 1 - Trang 191-220 - 1999
Adrian J. Hobbs, Annie Higgs, Salvador Moncada
▪ Abstract  Nitric oxide (NO) regulates numerous physiological processes, including neurotransmission, smooth muscle contractility, platelet reactivity, and the cytotoxic activity of immune cells. Because of the ubiquitous nature of NO, inappropriate release of this mediator has been linked to the pathogenesis of a number of disease states. This provides the rationale for the design of the...... hiện toàn bộ
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
Annual Review of Pharmacology and Toxicology - Tập 56 Số 1 - Trang 103-122 - 2016
Maggie Bobbin, John J. Rossi
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this resurgence possible. More than 20 RNAi-based therapeutics are currently in clinical trials, and several of these are Phase III trials. Continued ...... hiện toàn bộ
Therapeutic Oligonucleotides: State of the Art
Annual Review of Pharmacology and Toxicology - Tập 59 Số 1 - Trang 605-630 - 2019
Smith Rjh, Rula Zain
Oligonucleotides (ONs) can interfere with biomolecules representing the entire extended central dogma. Antisense gapmer, steric block, splice-switching ONs, and short interfering RNA drugs have been successfully developed. Moreover, antagomirs (antimicroRNAs), microRNA mimics, aptamers, DNA decoys, DNAzymes, synthetic guide strands for CRISPR/Cas, and innate immunity-stimulating ONs are a...... hiện toàn bộ
Cell Signaling and Neuronal Death
Annual Review of Pharmacology and Toxicology - Tập 47 Số 1 - Trang 117-141 - 2007
Makoto R. Hara, Solomon H. Snyder
The past few decades have revealed that cell death can be precisely programmed with two principal forms, apoptosis and necrosis. Besides pathophysiological alterations, physiologic processes, such as the pruning of neurons during normal development and the involution of the thymus, involve apoptosis. This review focuses on the role of inter- and intracellular signaling systems in cell dea...... hiện toàn bộ
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