Annual Review of Pharmacology and Toxicology

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MOLECULAR DETERMINANTS OF DRUG BINDING AND ACTION ON L-TYPE CALCIUM CHANNELS
Annual Review of Pharmacology and Toxicology - Tập 37 Số 1 - Trang 361-396 - 1997
Gregory H. Hockerman, Blaise Z. Peterson, and Barry D. Johnson, William A. Catterall
▪ Abstract  The crucial role of L-type Ca2+ channels in the initiation of cardiac and smooth muscle contraction has made them major therapeutic targets for the treatment of cardiovascular disease. L-type channels share a common pharmacological profile, including high-affinity voltage- and frequency-dependent block by the phenylalkylamines, the benz(othi)azepines, and ...... hiện toàn bộ
The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease
Annual Review of Pharmacology and Toxicology - Tập 53 Số 1 - Trang 89-106 - 2013
Naval P. Shanware, Kevin Bray, Robert T. Abraham
A fundamental imperative for mammalian cells is to coordinate cell metabolism and growth with environmentally induced stress. This review focuses on three highly integrated networks—the phosphoinositide 3-kinase (PI3K) signaling cascade, intermediate metabolism, and autophagy—that work together to maintain cellular homeostasis under basal conditions and to drive cell-mass accumulation and...... hiện toàn bộ
CO AS A CELLULAR SIGNALING MOLECULE
Annual Review of Pharmacology and Toxicology - Tập 46 Số 1 - Trang 411-449 - 2006
Hong Pyo Kim, Stefan W. Ryter, Augustine M.K. Choi
▪ Abstract  Many biological functions of heme oxygenase (HO), such as cytoprotection against oxidative stress, vasodilation, neurotransmission in the central or peripheral nervous systems, and anti-inflammatory, anti-apoptotic, or anti-proliferative potential, have been attributed to its enzymatic byproduct carbon monoxide (CO), although roles for biliverdin/bilirubin and iron have also be...... hiện toàn bộ
Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation
Annual Review of Pharmacology and Toxicology - Tập 49 Số 1 - Trang 123-150 - 2009
Takao Shimizu
Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal roles in immune regulation and self-defense, and in the maintenance of homeostasis in living systems. They are produced by multistep enzymatic pathways, which are initiated by the de-esterification of memb...... hiện toàn bộ
Neuroendocrine Pharmacology of Serotonergic (5-HT) Neurons
Annual Review of Pharmacology and Toxicology - Tập 31 Số 1 - Trang 289-320 - 1991
Louis D. Van de Kar
The Mechanisms of Acrylamide Axonopathy
Annual Review of Pharmacology and Toxicology - Tập 25 Số 1 - Trang 643-666 - 1985
Matthew S. Miller, Peter S. Spencer
Covalent Modifications of G-Proteins
Annual Review of Pharmacology and Toxicology - Tập 33 Số 1 - Trang 201-241 - 1993
Harvey Yamane, B K Fung
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Annual Review of Pharmacology and Toxicology - Tập 47 Số 1 - Trang 699-729 - 2007
John A. Dani, Daniel Bertrand
Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics. Structural and functional diversity and the broad presynaptic, postsynaptic, and nonsynaptic locations of nAChRs underlie their mainly modulatory roles throughout the mammalian...... hiện toàn bộ
Structure-Function of the G Protein–Coupled Receptor Superfamily
Annual Review of Pharmacology and Toxicology - Tập 53 Số 1 - Trang 531-556 - 2013
Vsevolod Katritch, Vadim Cherezov, Raymond C. Stevens
During the past few years, crystallography of G protein–coupled receptors (GPCRs) has experienced exponential growth, resulting in the determination of the structures of 16 distinct receptors—9 of them in 2012 alone. Including closely related subtype homology models, this coverage amounts to approximately 12% of the human GPCR superfamily. The adrenergic, rhodopsin, and adenosine receptor...... hiện toàn bộ
Anesthetics and Ion Channels: Molecular Models and Sites of Action
Annual Review of Pharmacology and Toxicology - Tập 41 Số 1 - Trang 23-51 - 2001
Tomohiro Yamakura, Edward Bertaccini, James R. Trudell, R. Adron Harris
The mechanisms of general anesthesia in the central nervous system are finally yielding to molecular examination. As a result of research during the past several decades, a group of ligand-gated ion channels have emerged as plausible targets for general anesthetics. Molecular biology techniques have greatly accelerated attempts to classify ligand-gated ion channel sensitivity to general an...... hiện toàn bộ
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