Annual Review of Pharmacology and Toxicology

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
INHIBITION OF NITRIC OXIDE SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET
Annual Review of Pharmacology and Toxicology - Tập 39 Số 1 - Trang 191-220 - 1999
Adrian J. Hobbs, Annie Higgs, Salvador Moncada
▪ Abstract  Nitric oxide (NO) regulates numerous physiological processes, including neurotransmission, smooth muscle contractility, platelet reactivity, and the cytotoxic activity of immune cells. Because of the ubiquitous nature of NO, inappropriate release of this mediator has been linked to the pathogenesis of a number of disease states. This provides the rationale for the design of the...... hiện toàn bộ
Thioredoxin Reductase Inhibition for Cancer Therapy
Annual Review of Pharmacology and Toxicology - Tập 62 Số 1 - Trang 177-196 - 2022
Radosveta Gencheva, Elias S.J. Arnér
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic compounds. Many such compounds also yield cytotoxicity toward cancer cells in culture or in mouse models, and most compounds are likely to irreversibly modify the easily accessible selenocysteine residue in TrxR1, thereby in...... hiện toàn bộ
Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs
Annual Review of Pharmacology and Toxicology - Tập 24 Số 1 - Trang 387-423 - 1984
Luc M. Hondeghem, Bertram G. Katzung
Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts
Annual Review of Pharmacology and Toxicology - Tập 43 Số 1 - Trang 149-173 - 2003
Xinxin Ding, Laurence S. Kaminsky
Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in target tissue metabolic activation of xenobiotic compounds. They may also determine drug efficacy and influence the tissue burden of foreign chemicals or bioavailability of therapeutic agents. This review focuses on xenobiotic-metabolizing CYPs of the human respiratory and gastrointestinal tracts, includin...... hiện toàn bộ
DƯỢC LÝ HỌC VÀ CHỨC NĂNG CỦA THỤ THỂ GLUTAMATE METABOTROPIC Dịch bởi AI
Annual Review of Pharmacology and Toxicology - Tập 37 Số 1 - Trang 205-237 - 1997
P. Jeffrey Conn, Jean‐Philippe Pin
▪ Tóm tắt: Khoảng giữa cho đến cuối thập niên 1980, các nghiên cứu đã được công bố chứng minh sự tồn tại của các thụ thể glutamate không phải là kênh cation điều khiển ligan mà được kết nối với hệ thống hiệu ứng thông qua các protein liên kết với GTP. Kể từ những báo cáo ban đầu đó, đã có sự tiến bộ vượt bậc trong việc đặc trưng hóa các thụ thể glutamate metabotropic (mGluRs), bao gồm việ...... hiện toàn bộ
#thụ thể glutamate metabotropic #GTP-binding proteins #nhân bản cDNA #chất chủ vận và chất đối kháng #não động vật có vú #dược lý thần kinh
Efficient Analysis of Experimental Observations
Annual Review of Pharmacology and Toxicology - Tập 20 Số 1 - Trang 441-462 - 1980
W. J. Dixon
Angiotensin Receptors and Their Therapeutic Implications
Annual Review of Pharmacology and Toxicology - Tập 36 Số 1 - Trang 281-306 - 1996
Kathy K. Griendling
Lipid vs Protein Theories of Alcohol Action in the Nervous System
Annual Review of Pharmacology and Toxicology - Tập 36 Số 1 - Trang 185-201 - 1996
Robert W. Peoples, Chaoying Liu, Forrest F. Weight
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
Annual Review of Pharmacology and Toxicology - Tập 47 Số 1 - Trang 89-116 - 2007
Thomas W. Kensler, Nobunao Wakabayashi, Shyam Biswal
Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from endogenous and exogenous stresses. The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway. These mice are more sensitive to the hepatic, pulmonary, ovarian, and neurotoxic consequences of acute exposures to environmental agents and drugs, inflammatory stres...... hiện toàn bộ
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
Annual Review of Pharmacology and Toxicology - Tập 47 Số 1 - Trang 629-656 - 2007
Michael P. Murphy, Robin A.J. Smith
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Consequently, the selective inhibition of mitochondrial oxidative damage is a promising therapeutic strategy. One way to do this is to invent antioxidants that are selectively accumulated into mitochondria within patients. Such mitochondria-targeted antioxidants have been developed by conjugating the lipophilic...... hiện toàn bộ
Tổng số: 130   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10