Annual Review of Neuroscience
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Neurodegenerative Tauopathies▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent filamentous tau inclusions and brain degeneration in the absence of β-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified by sporadic corticobasal degeneration, progressive supranuclear pa... ...
Annual Review of Neuroscience - Tập 24 Số 1 - Trang 1121-1159 - 2001
Intentional Maps in Posterior Parietal Cortex▪ Abstract The posterior parietal cortex (PPC), historically believed to be a sensory structure, is now viewed as an area important for sensory-motor integration. Among its functions is the forming of intentions, that is, high-level cognitive plans for movement. There is a map of intentions within the PPC, with different subregions dedicated to the planning of eye movements, reaching move... ...
Annual Review of Neuroscience - Tập 25 Số 1 - Trang 189-220 - 2002
Protein Synthesis at Synaptic Sites on Dendrites ▪ Abstract Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous elements are positioned beneath synapses and translate a particular population of dendritic mRNAs. The localization of translation ... ...
Annual Review of Neuroscience - Tập 24 Số 1 - Trang 299-325 - 2001
Establishment of Axon-Dendrite Polarity in Developing Neurons Neurons are among the most highly polarized cell types in the body, and the polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain. Significant progress has been made in the identification of the cellular and molecular mechanisms underlying the establishment of neuronal polarity using primarily in vitro approaches such as dis... ...
Annual Review of Neuroscience - Tập 32 Số 1 - Trang 347-381 - 2009
THE PLASTIC HUMAN BRAIN CORTEX Plasticity is an intrinsic property of the human brain and represents evolution's invention to enable the nervous system to escape the restrictions of its own genome and thus adapt to environmental pressures, physiologic changes, and experiences. Dynamic shifts in the strength of preexisting connections across distributed neural networks, changes in task-related cortico-cortical and corti... ...
Annual Review of Neuroscience - Tập 28 Số 1 - Trang 377-401 - 2005
The Molecular Neurobiology of the Acetylcholine Receptor
Annual Review of Neuroscience - Tập 9 Số 1 - Trang 383-413 - 1986
The Perirhinal Cortex Anatomically, the perirhinal cortex sits at the boundary between the medial temporal lobe and the ventral visual pathway. It has prominent interconnections not only with both these systems, but also with a wide range of unimodal and polymodal association areas. Consistent with these diverse projections, neurophysiological studies reveal a multidimensional set of mnemonic signals that incl... ...
Annual Review of Neuroscience - Tập 37 Số 1 - Trang 39-53 - 2014
NEURONAL CIRCUITS OF THE NEOCORTEX ▪ Abstract We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, ... ...
Annual Review of Neuroscience - Tập 27 Số 1 - Trang 419-451 - 2004
Coupling Mechanism and Significance of the BOLD Signal: A Status Report Functional magnetic resonance imaging (fMRI) provides a unique view of the working human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blood flow and blood oxygenation, which are coupled to underlying neuronal activity by a process termed neurovascular coupling. Over the past 10 years, a ran... ...
Annual Review of Neuroscience - Tập 37 Số 1 - Trang 161-181 - 2014
The Protein Kinase C Family for Neuronal Signaling
Annual Review of Neuroscience - Tập 17 Số 1 - Trang 551-567 - 1994
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