Protein Synthesis at Synaptic Sites on Dendrites

Annual Review of Neuroscience - Tập 24 Số 1 - Trang 299-325 - 2001
Oswald Steward1,2, Erin M. Schuman1,3
1Division of Biology 216-76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, 91125
2Reeve-Irvine Research Center and Departments of Anatomy/Neurobiology and Neurobiology and Behavior, College of Medicine, University of California at Irvine, Irvine, California 92697, USA. [email protected]
3Reeve-Irvine Research Center and Departments of Anatomy/Neurobiology and Neurobiology and Behavior, College of Medicine, University of California at Irvine, Irvine, California 92697;

Tóm tắt

▪ Abstract  Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous elements are positioned beneath synapses and translate a particular population of dendritic mRNAs. The localization of translation machinery and mRNAs at synapses endows individual synapses with the capability to independently control synaptic strength through the local synthesis of proteins. The present review discusses recent studies linking synaptic plasticity to dendritic protein synthesis and mRNA trafficking and considers how these processes are regulated. We summarize recent information about how synaptic signaling is coupled to local translation and to the delivery of newly transcribed mRNAs to activated synaptic sites and how local translation may play a role in activity-dependent synaptic modification.

Từ khóa


Tài liệu tham khảo

10.1038/266736a0

Bagni C, 2000, J. Neurosci., 20, 1, 10.1523/JNEUROSCI.20-10-j0004.2000

10.1073/pnas.93.24.13445

10.1002/(SICI)1097-4547(19960301)43:5<565::AID-JNR6>3.0.CO;2-G

10.1006/mcne.1996.0009

10.1073/pnas.86.20.8113

10.1016/S0092-8674(00)80125-7

10.1523/JNEUROSCI.10-06-01788.1990

10.1016/S0092-8674(00)81653-0

Chicurel ME, 1990, Soc. Neurosci. Abstr., 16, 353

10.1073/pnas.90.23.11411

10.1152/jn.1996.76.2.953

10.1002/(SICI)1098-1063(1998)8:2<160::AID-HIPO8>3.3.CO;2-J

10.1073/pnas.94.10.5401

10.1037/0033-2909.96.3.518

10.1016/0896-6273(92)90133-X

Engert F, 1996, Soc. Neurosci. Abstr., 22, 516

10.1523/JNEUROSCI.13-03-01010.1993

10.1523/JNEUROSCI.17-05-01539.1997

10.1016/0006-8993(88)90008-X

10.1038/385533a0

Furuichi T, 1993, Recept. Channels, 1, 11

10.1038/336674a0

10.1523/JNEUROSCI.17-06-02006.1997

10.1073/pnas.88.5.1808

10.1006/mcne.1996.0594

10.1038/ng0193-36

10.1126/science.288.5469.1254

10.1126/science.7886457

10.1126/science.273.5280.1402

10.1523/JNEUROSCI.19-01-00288.1999

10.1523/JNEUROSCI.16-24-07812.1996

10.1091/mbc.10.9.2945

Laudry CF, 1993, Soc. Neurosci. Abstr., 19, 1745

10.1007/BF02527725

10.1016/0006-8993(79)91003-5

10.1016/0306-4522(83)90010-6

10.1073/pnas.92.12.5734

10.1016/0896-6273(95)90299-6

10.1128/MCB.19.3.2212

10.1016/S0092-8674(00)80484-5

10.1126/science.274.5293.1678

10.1073/pnas.91.23.10800

10.1126/science.3775383

10.1523/JNEUROSCI.16-10-03189.1996

10.1101/lm.4.2.230

10.1523/JNEUROSCI.16-08-02444.1996

10.1016/0304-3940(89)90222-X

10.1016/0306-4522(89)90001-8

10.1523/JNEUROSCI.17-14-05416.1997

10.1523/JNEUROSCI.19-18-07823.1999

10.1016/0306-4522(88)90316-8

Palacios-Pru EL, 1981, J. Submicrosc. Cytol., 13, 145

10.1002/(SICI)1097-4695(199710)33:4<473::AID-NEU10>3.0.CO;2-D

10.1073/pnas.90.5.1741

10.1038/74908

10.1111/j.1460-9568.1997.tb01629.x

10.1523/JNEUROSCI.17-05-01691.1997

10.1523/JNEUROSCI.11-09-02881.1991

Rao A, 1991, Soc. Neurosci. Abstr., 17, 379

10.1523/JNEUROSCI.20-03-00969.2000

10.1523/JNEUROSCI.20-09-03165.2000

10.1016/S0896-6273(01)80023-4

10.1126/science.8290963

Severt WL, 2000, J. Cell. Sci., 112, 3691, 10.1242/jcs.112.21.3691

10.1073/pnas.94.26.14770

10.1038/72915

Smith WB, 1999, Soc. Neurosci. Abstr., 25, 467

10.1007/BF00298517

10.1523/JNEUROSCI.04-12-03080.1984

10.1101/SQB.1983.048.01.077

10.1016/S0896-6273(01)80041-6

10.1523/JNEUROSCI.06-02-00412.1986

10.1007/BF02284837

10.1016/S0079-6123(08)60013-8

10.1523/JNEUROSCI.19-18-07834.1999

10.1523/JNEUROSCI.02-03-00284.1982

10.1002/jnr.490300408

10.1523/JNEUROSCI.08-01-00176.1988

10.1523/JNEUROSCI.06-10-03079.1986

Steward O, Singer RH. 1997. The intracellular mRNA sorting system: postal zones, zip codes, mail bags and mail boxes. InmRNA Metabolism and Post-Transcriptional Gene Regulation, ed. JB Hartford, DR Morris, pp. 127–46. New York: Wiley-Liss

10.1016/S0896-6273(00)80591-7

Tang SJ, 1999, Proc. Annu. Meet. Soc. Neurosci., 25, 468

Tang SJ, 1998, Proc. Annu. Meet. Soc. Neurosci., 24, 328

10.1523/JNEUROSCI.17-24-09492.1997

10.1523/JNEUROSCI.16-19-05967.1996

10.1016/S0169-328X(99)00310-1

10.1002/jnr.490390113

10.1016/1044-7431(91)90060-2

10.1073/pnas.90.15.7168

10.1073/pnas.94.10.5395

10.1073/pnas.85.7.2368

10.1152/jn.1990.64.4.1186

10.1128/MCB.19.3.2220

10.1016/S0896-6273(00)80630-3

Thông tin
Thông tin xuất bản

Annual Review of Neuroscience

Tập 24 Số 1

299-325

Thông tin tác giả