Annual Review of Medicine
SCIE-ISI SCOPUS (1950-1958,1960-2023)
1545-326X
0066-4219
Mỹ
Cơ quản chủ quản: ANNUAL REVIEWS , Annual Reviews Inc.
Lĩnh vực:
Biochemistry, Genetics and Molecular Biology (miscellaneous)Medicine (miscellaneous)
Các bài báo tiêu biểu
The Mechanisms of Action of PPARs ▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs) within promoters. PPARs bind as heterodimers with a retinoid X receptor and, upon binding agoni... ... hiện toàn bộ
Tập 53 Số 1 - Trang 409-435 - 2002
Mechanisms of Cancer Drug Resistance ▪ Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Freque... ... hiện toàn bộ
Tập 53 Số 1 - Trang 615-627 - 2002
The Expanded Biology of Serotonin Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a wide range of neuropsychological processes, and drugs that target serotonin receptors are used widely in psychiatry and neurology. However, most serotonin is found outside the central nervous system, and virtually all of the 15 serotonin receptors are expressed outside as well as within the brain. S... ... hiện toàn bộ
Tập 60 Số 1 - Trang 355-366 - 2009
MicroRNAs in Cancer MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer... ... hiện toàn bộ
Tập 60 Số 1 - Trang 167-179 - 2009
Nanoparticle Delivery of Cancer Drugs Nanomedicine, the application of nanotechnology to medicine, enabled the development of nanoparticle therapeutic carriers. These drug carriers are passively targeted to tumors through the enhanced permeability and retention effect, so they are ideally suited for the delivery of chemotherapeutics in cancer treatment. Indeed, advances in nanomedicine have rapidly translated into clinical pr... ... hiện toàn bộ
Tập 63 Số 1 - Trang 185-198 - 2012
ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING▪ Abstract Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibi... ... hiện toàn bộ
Tập 46 Số 1 - Trang 223-234 - 1995
Cancer Stem Cells: Models and Concepts Although monoclonal in origin, most tumors appear to contain a heterogeneous population of cancer cells. This observation is traditionally explained by postulating variations in tumor microenvironment and coexistence of multiple genetic subclones, created by progressive and divergent accumulation of independent somatic mutations. An additional explanation, however, envisages human tumors ... ... hiện toàn bộ
Tập 58 Số 1 - Trang 267-284 - 2007
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and FrailtyInterleukin-6 (IL-6) is a proinflammatory cytokine that is normally tightly regulated and expressed at low levels, except during infection, trauma, or other stress. Among several factors that down-regulate IL-6 gene expression are estrogen and testosterone. After menopause or andropause, IL-6 levels are elevated, even in the absence of infection, trauma, or stress. IL-6 is a potent mediato... ... hiện toàn bộ
Tập 51 Số 1 - Trang 245-270 - 2000
The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a funda... ... hiện toàn bộ
Tập 66 Số 1 - Trang 311-328 - 2015
Global Epidemiology of Influenza: Past and Present ▪ Abstract Pandemics are the most dramatic presentation of influenza. Three have occurred in the twentieth century: the 1918 H1N1 pandemic, the 1957 H2N2 pandemic, and the 1968 H3N2 pandemic. The tools of molecular epidemiology have been applied in an attempt to determine the origin of pandemic viruses and to understand what made them such successful pathogens. An excellent example of th... ... hiện toàn bộ
Tập 51 Số 1 - Trang 407-421 - 2000