Annual Review of Medicine

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The Mechanisms of Action of PPARs
Annual Review of Medicine - Tập 53 Số 1 - Trang 409-435 - 2002
Joel P. Berger, David E. Moller
▪ Abstract  The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs) within promoters. PPARs bind as heterodimers with a retinoid X receptor and, upon binding agoni...... hiện toàn bộ
RU486 (MIFEPRISTONE): Các Cơ Chế Hoạt Động và Ứng Dụng Lâm Sàng Dịch bởi AI
Annual Review of Medicine - Tập 48 Số 1 - Trang 129-156 - 1997
F. Cadepond, A Ulmann, E.E. Baulieu
▪ Tóm tắt  RU486 (mifepristone) đã chứng minh là một tác nhân kháng progesterone và kháng glucocorticosteroid rất hiệu quả ở người. Cơ chế hoạt động liên quan đến các thụ thể nội bào của các hormone bị đối kháng (progesterone và glucocorticosteroid). Ở mức độ phân tử, các đặc điểm quan trọng nhất là độ bám dính cao với thụ thể, sự tương tác của nhóm phenylaminodimethyl tại vị trí 11β với m...... hiện toàn bộ
Cellular Mechanisms of Cholestasis
Annual Review of Medicine - Tập 37 Số 1 - Trang 297-318 - 1986
David G. Oelberg, Roger Lester
GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS
Annual Review of Medicine - Tập 45 Số 1 - Trang 391-405 - 1994
P. Michael Conn, William F. Crowley
▪ Abstract  GnRH and its analogues have led to exciting new avenues of therapy in virtually every subspecialty of internal medicine as well as in gynecology, pediatrics, and urology. Since their discovery in 1971, it has been demonstrated that GnRH and its analogues enable medical professionals to influence the hypothalamic-pituitary-gonadal axis in two distinct classes of therapeutic app...... hiện toàn bộ
Novel Platelet Inhibitors
Annual Review of Medicine - Tập 52 Số 1 - Trang 161-184 - 2001
Joel Bennett
▪ Abstract  Platelet-inhibitory drugs are of proven benefit to individuals who suffer from atherosclerotic cardiovascular disease. Despite substantial effort to identify more potent platelet-inhibitory agents, aspirin, an irreversible inhibitor of platelet cyclooxygenase activity, remains the standard against which other drugs are judged. Drugs that appear to be at least as efficacious as...... hiện toàn bộ
Surgical Implications of Obesity
Annual Review of Medicine - Tập 49 Số 1 - Trang 215-234 - 1998
Louis Flancbaum, Patricia S. Choban
Obesity is perhaps the most significant public health problem facing the United States today. Obese patients are at increased risk for numerous medical problems, which can adversely affect surgical outcome. However, these risks have not uniformly translated into increased or prohibitive operative morbidity and mortality in this population. With appropriate perioperative precautions and mon...... hiện toàn bộ
Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates
Annual Review of Medicine - Tập 62 Số 1 - Trang 333-345 - 2011
David H. Perlmutter
Alpha-1-antitrypsin (AT) deficiency is the most common genetic cause of liver disease in children. The primary pathological issue is a point mutation that renders an abundant hepatic secretory glycoprotein prone to altered folding and a tendency to polymerize and aggregate. However, the expression of serious liver damage among homozygotes is dependent on genetic and/or environmental modif...... hiện toàn bộ
The Autonomic Nervous System in Congestive Heart Failure
Annual Review of Medicine - Tập 37 Số 1 - Trang 235-247 - 1986
Gary S. Francis, Jay N. Cohn
Nanoparticle Delivery of Cancer Drugs
Annual Review of Medicine - Tập 63 Số 1 - Trang 185-198 - 2012
Andrew Z. Wang, Róbert Langer, Omid C. Farokhzad
Nanomedicine, the application of nanotechnology to medicine, enabled the development of nanoparticle therapeutic carriers. These drug carriers are passively targeted to tumors through the enhanced permeability and retention effect, so they are ideally suited for the delivery of chemotherapeutics in cancer treatment. Indeed, advances in nanomedicine have rapidly translated into clinical pr...... hiện toàn bộ
Circulating Tumor Cells and Circulating Tumor DNA
Annual Review of Medicine - Tập 63 Số 1 - Trang 199-215 - 2012
Catherine Alix‐Panabières, Heidi Schwarzenbach, Klaus Pantel
Solid tumors derived from epithelial tissues (carcinomas) are responsible for 90% of all new cancers in Europe, and the main four tumor entities are breast, prostate, lung, and colon cancer. Present tumor staging is mainly based on local tumor extension, metastatic lymph node involvement, and evidence of overt distant metastasis obtained by imaging technologies. However, these staging proc...... hiện toàn bộ
Tổng số: 80   
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