Annual Review of Medicine

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The Mechanisms of Action of PPARs
Annual Review of Medicine - Tập 53 Số 1 - Trang 409-435 - 2002
Joel P. Berger, David E. Moller
▪ Abstract  The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs) within promoters. PPARs bind as heterodimers with a retinoid X receptor and, upon binding agoni...... hiện toàn bộ
Serum Creatinine and Renal Function
Annual Review of Medicine - Tập 39 Số 1 - Trang 465-490 - 1988
Andrew S. Levey, Ronald D. Perrone, Nicolaos E. Madias
Infant Botulism
Annual Review of Medicine - Tập 31 Số 1 - Trang 541-560 - 1980
Stephen S. Arnon
Pathophysiology of Preeclampsia
Annual Review of Medicine - Tập 32 Số 1 - Trang 273-289 - 1981
M. D. Lindheimer, Adrian I. Katz
Diagnosis and Therapy of Acute Myeloid Leukemia in the Era of Molecular Risk Stratification
Annual Review of Medicine - Tập 67 Số 1 - Trang 59-72 - 2016
Krishna V. Komanduri, Ross L. Levine
The diagnosis and risk stratification of acute myeloid leukemia (AML) primarily rely on morphologic analysis and assessment of karyotype by chromosome banding analysis. For decades, standard AML induction therapy has utilized the combination of anthracyclines and cytarabine. Despite the use of postremission therapy, less than half of patients with AML will be cured of their disease. Allog...... hiện toàn bộ
mRNA Vaccines in the COVID-19 Pandemic and Beyond
Annual Review of Medicine - Tập 73 Số 1 - Trang 17-39 - 2022
Michael J. Hogan, Norbert Pardi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. This extraordinary situation prompted entities in government, industry, and academia to work together at unprecedented speed to develop...... hiện toàn bộ
APOPTOSIS AND DISEASE: Regulation and Clinical Relevance of Programmed Cell Death
Annual Review of Medicine - Tập 48 Số 1 - Trang 267-281 - 1997
Charles M. Rudin, Craig B. Thompson
▪ Abstract  Regulation of the homeostatic balance between cell proliferation and cell death is essential for development and maintenance of multicellular organisms. Physiologic, or programmed, cell death is dependent on a genetically encoded and evolutionarily conserved pathway that induces a form of cellular suicide known as apoptosis. In the past decade, it has become clear that the regu...... hiện toàn bộ
Post-Transplant Lymphoproliferative Disorders
Annual Review of Medicine - Tập 56 Số 1 - Trang 29-44 - 2005
Stephen Gottschalk, Cliona M. Rooney, Helen E. Heslop
Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after hematopoietic stem cell or solid organ transplantation. The majority of PTLD is of B-cell origin and associated with Epstein-Barr virus (EBV). During the past decade progress has been made in better understanding the pathogenesis of PTLD, and early detection strategies, such as serial measurement o...... hiện toàn bộ
Cellular Mechanisms of Cholestasis
Annual Review of Medicine - Tập 37 Số 1 - Trang 297-318 - 1986
David G. Oelberg, Roger Lester
Advances in Autism
Annual Review of Medicine - Tập 60 Số 1 - Trang 367-380 - 2009
Daniel H. Geschwind
Autism is a common childhood neurodevelopmental disorder with strong genetic liability. It is not a unitary entity but a clinical syndrome, with variable deficits in social behavior and language, restrictive interests, and repetitive behaviors. Recent advances in the genetics of autism emphasize its etiological heterogeneity, with each genetic susceptibility locus accounting for only a sm...... hiện toàn bộ
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