Annual Review of Medicine
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The Mechanisms of Action of PPARs
Annual Review of Medicine - Tập 53 Số 1 - Trang 409-435 - 2002
▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group
of three nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by
different genes. PPARs are ligand-regulated transcription factors that control
gene expression by binding to specific response elements (PPREs) within
promoters. PPARs bind as heterodimers with a retinoid X receptor and, upon
binding agonist, inter...
Asthma Genetics: From Linear to Multifactorial Approaches
Annual Review of Medicine - Tập 59 Số 1 - Trang 327-341 - 2008
Asthma risk has a clear hereditary component but, unexpectedly, the majority of
reported associations between genetic variants and asthma have not been
consistently replicated across studies. Methodological flaws have been indicated
as a possible explanation for these inconsistencies. However, an alternative
explanation is that the effects of genetic variants depend on other factors
whose frequenc...
Toward a Comprehensive Set of Asthma Susceptibility Genes
Annual Review of Medicine - Tập 58 Số 1 - Trang 171-184 - 2007
Epidemiological and twin studies have demonstrated that asthma is under genetic
and environmental influences. Numerous candidate gene association studies as
well as genome-wide linkage scans have followed, aiming to elucidate the genetic
architecture underlying this complex disease. Several promising asthma
susceptibility genes were identified, and a comprehensive catalogue of these
genes seems a ...
Global Epidemiology of Influenza: Past and Present
Annual Review of Medicine - Tập 51 Số 1 - Trang 407-421 - 2000
▪ Abstract Pandemics are the most dramatic presentation of influenza. Three
have occurred in the twentieth century: the 1918 H1N1 pandemic, the 1957 H2N2
pandemic, and the 1968 H3N2 pandemic. The tools of molecular epidemiology have
been applied in an attempt to determine the origin of pandemic viruses and to
understand what made them such successful pathogens. An excellent example of
this avenue...
GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS
Annual Review of Medicine - Tập 45 Số 1 - Trang 391-405 - 1994
▪ Abstract GnRH and its analogues have led to exciting new avenues of therapy
in virtually every subspecialty of internal medicine as well as in gynecology,
pediatrics, and urology. Since their discovery in 1971, it has been demonstrated
that GnRH and its analogues enable medical professionals to influence the
hypothalamic-pituitary-gonadal axis in two distinct classes of therapeutic
applications...
Aspirin in the Prevention of Cardiovascular Disease and Cancer
Annual Review of Medicine - Tập 72 Số 1 - Trang 473-495 - 2021
More than a century after its synthesis, daily aspirin, given at a low dose, is
a milestone treatment for the secondary prevention of cardiovascular disease
(CVD). Its role in primary prevention of CVD is still debated. Older randomized
controlled trials showed that aspirin reduced the low incidence of myocardial
infarction but correspondingly increased the low incidence of serious
gastrointestina...
ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULES IN HUMAN DISEASE
Annual Review of Medicine - Tập 45 Số 1 - Trang 361-378 - 1994
▪ Abstract An effective host response to infection or tissue damage requires
focal accumulation of leukocytes. Leukocyte adhesion to the vessel wall, a key
step in this process, depends on the ordered expression of specific endothelial
cell surface molecules. The endothelial molecules that support adhesion include
selectins that recognize leukocyte cell surface glycoconjugates as well as
members ...
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