Annual Review of Cell and Developmental Biology

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TRANSPORT VESICLE DOCKING: SNAREs and Associates
Annual Review of Cell and Developmental Biology - Tập 12 Số 1 - Trang 441-461 - 1996
Suzanne R. Pfeffer
▪ Abstract  Proteins that function in transport vesicle docking are being identified at a rapid rate. So-called v- and t-SNAREs form the core of a vesicle docking complex. Additional accessory proteins are required to protect SNAREs from promiscuous binding and to deprotect SNAREs under conditions in which transport vesicle docking should occur. Because access to SNAREs must be regulated, other pr... hiện toàn bộ
Hormonal Modulation of Plant Immunity
Annual Review of Cell and Developmental Biology - Tập 28 Số 1 - Trang 489-521 - 2012
Corné M. J. Pieterse, Dieuwertje van der Does, Christos Zamioudis, Antonio Leon‐Reyes, Saskia C. M. Van Wees
Plant hormones have pivotal roles in the regulation of plant growth, development, and reproduction. Additionally, they emerged as cellular signal molecules with key functions in the regulation of immune responses to microbial pathogens, insect herbivores, and beneficial microbes. Their signaling pathways are interconnected in a complex network, which provides plants with an enormous regulatory pot... hiện toàn bộ
The Evolution, Regulation, and Function of Placenta-Specific Genes
Annual Review of Cell and Developmental Biology - Tập 24 Số 1 - Trang 159-181 - 2008
Saara Rawn, James C. Cross
A number of placenta-specific genes (e.g., Tpbp, Plac1, Syncytin, and retrotransposon-associated genes such as Peg10, Rtl1, Endothelin B receptor, Insl4, Leptin, Midline1, and Pleiotrophin), enhancer elements (e.g., glycoprotein hormone α-subunit) and gene isoforms (e.g., 3βHSD, Cyp19), as well as placenta-specific members of gene families (e.g., Gcm1, Mash2, Rhox, Esx1, Cathepsin, PAG, TKDP, Psg,... hiện toàn bộ
TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress
Annual Review of Cell and Developmental Biology - Tập 32 Số 1 - Trang 255-278 - 2016
Jun Ren, Rosa Puertollano
In recent years, our vision of lysosomes has drastically changed. Formerly considered to be mere degradative compartments, they are now recognized as key players in many cellular processes. The ability of lysosomes to respond to different stimuli revealed a complex and coordinated regulation of lysosomal gene expression. This review discusses the participation of the transcription factors TFEB and... hiện toàn bộ
Centriole Biogenesis: From Identifying the Characters to Understanding the Plot
Annual Review of Cell and Developmental Biology - Tập 33 Số 1 - Trang 23-49 - 2017
Niccoló Banterle, Pierre Gönczy
The centriole is a beautiful microtubule-based organelle that is critical for the proper execution of many fundamental cellular processes, including polarity, motility, and division. Centriole biogenesis, the making of this miniature architectural wonder, has emerged as an exemplary model to dissect the mechanisms governing the assembly of a eukaryotic organelle. Centriole biogenesis relies on a s... hiện toàn bộ
The Biology of Cancer Stem Cells
Annual Review of Cell and Developmental Biology - Tập 23 Số 1 - Trang 675-699 - 2007
Neethan A. Lobo, Yohei Shimono, Dalong Qian, Michael F. Clarke
Cancers originally develop from normal cells that gain the ability to proliferate aberrantly and eventually turn malignant. These cancerous cells then grow clonally into tumors and eventually have the potential to metastasize. A central question in cancer biology is, which cells can be transformed to form tumors? Recent studies elucidated the presence of cancer stem cells that have the exclusive a... hiện toàn bộ
The Cellular Basis of Kidney Development
Annual Review of Cell and Developmental Biology - Tập 22 Số 1 - Trang 509-529 - 2006
Gregory R. Dressler
Mammalian kidney development has helped elucidate the general concepts of mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and branching morphogenesis. Through the use of genetically engineered mouse models, the manipulation of Xenopus and chick embryos, and the identification of human renal disease genes, the molecular bases for many of the early events in t... hiện toàn bộ
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Annual Review of Cell and Developmental Biology - Tập 12 Số 1 - Trang 463-519 - 1996
Keith Burridge, Magdalena Chrzanowska‐Wodnicka
▪ Abstract  Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, ... hiện toàn bộ
Generating Neuronal Diversity in the Mammalian Cerebral Cortex
Annual Review of Cell and Developmental Biology - Tập 31 Số 1 - Trang 699-720 - 2015
Simona Lodato, Paola Arlotta
The neocortex is the part of the brain responsible for execution of higher-order brain functions, including cognition, sensory perception, and sophisticated motor control. During evolution, the neocortex has developed an unparalleled neuronal diversity, which still remains partly unclassified and unmapped at the functional level. Here, we broadly review the structural blueprint of the neocortex an... hiện toàn bộ
Regulation of Terminal Differentiation Programs in the Nervous System
Annual Review of Cell and Developmental Biology - Tập 27 Số 1 - Trang 681-696 - 2011
Oliver Hobert
The generation of individual neuron types in the nervous system is a multistep process whose endpoint is the expression of neuron type–specific batteries of terminal differentiation genes that determine the functional properties of a neuron. This review focuses on the regulatory mechanisms that are involved in controlling the terminally differentiated state of a neuron. I review several case studi... hiện toàn bộ
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