Regulation of Terminal Differentiation Programs in the Nervous System

Annual Review of Cell and Developmental Biology - Tập 27 Số 1 - Trang 681-696 - 2011
Oliver Hobert1
1Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032;

Tóm tắt

The generation of individual neuron types in the nervous system is a multistep process whose endpoint is the expression of neuron type–specific batteries of terminal differentiation genes that determine the functional properties of a neuron. This review focuses on the regulatory mechanisms that are involved in controlling the terminally differentiated state of a neuron. I review several case studies from invertebrate and vertebrate nervous systems that reveal that many terminal differentiation features of a neuron are coregulated via terminal selector transcription factors that initiate and maintain terminal differentiation programs.

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Annual Review of Cell and Developmental Biology

Tập 27 Số 1

681-696

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