3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon- γAnnals of Clinical Biochemistry - Tập 38 Số 3 - Trang 242-251 - 2001
Toshiko Morita, Kuniaki Saito, Masao Takemura, Naoya Maekawa, Suwako Fujigaki, Hidehiko Fujii, Hisayasu Wada, Shoji Takeuchi, Akio Noma, Mitsuru Seishima
3-Hydroxyanthranilic acid (3-HAA), a metabolite of L-tryptophan, accumulates in monocyte-derived cells (THP-1),but not in other celllines tested(MRC9, H4, U373MG, Wil-NS), following immune stimulation that induces indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the L-tryptophan-kynurenine pathway. We examined whether metabolites of the L-tryptophan-kynurenine pathway act to i...... hiện toàn bộ
Assays for Follicle Stimulating Hormone and Luteinising Hormone: Guidelines for the Provision of a Clinical Biochemistry ServiceAnnals of Clinical Biochemistry - Tập 24 Số 3 - Trang 246-262 - 1987
G.H. Beastall, K M Ferguson, Denis St J O’Reilly, Surajit Gorai, B. Sheridan
The measurement of serum follicle stimulating hormone (FSH) and luteinising hormone (LH), together with the appropriate sex steroid, is of great value in the investigation of delayed and precocious puberty, hypogonadism, subfertility, polycystic ovarian disease and hypothalamic-pituitary disorders. Dynamic function testing of the hypothalamic-pituitary-gonadal axis should be restricted to ...... hiện toàn bộ
LDLR gene synonymous mutation c.1813C>T results in mRNA splicing variation in a kindred with familial hypercholesterolaemiaAnnals of Clinical Biochemistry - Tập 52 Số 6 - Trang 680-684 - 2015
Clement Ho, Fathel Rahman Musa, Christine Bell, Simon W. Walker
Familial hypercholesterolaemia, one of the most common inherited diseases in the general population, is associated with mutations in at least three different genes including the low density lipoprotein receptor ( LDLR), apolipoprotein B ( APOB) and protein convertase subtilisin/kexin type 9 ( PCSK9) genes. In this report, we describe an unclassified DNA variant (c.1813C>T; p.Leu605Leu)...... hiện toàn bộ
Chemiluminescence Immunoassay for Progesterone in Plasma Incorporating Acridinium Ester Labelled AntigenAnnals of Clinical Biochemistry - Tập 25 Số 1 - Trang 27-34 - 1988
Stuart Miller, Michael S. Scott Morton, A. Turkes
A sensitive, solid-phase chemiluminescence immunoassay suitable for determining progesterone concentrations in plasma has been developed. The solid-phase antiserum was prepared by coupling a monoclonal progesterone-antibody, raised against a progesterone-11α-hemisuccinyl/bovine serum albumin conjugate, to cyanogen bromide activated cellulose. An 11α-progesteryl-2-carboxymethyltyramine-4-(...... hiện toàn bộ
New approaches towards laboratory diagnosis of isolated sulphite oxidase deficiencyAnnals of Clinical Biochemistry - Tập 41 Số 2 - Trang 157-159 - 2004
Jörn Oliver Sass, Toyofumi Nakanishi, Takako Sato, Akira Shimizu
Background: Molybdenum cofactor deficiency (resulting in combined deficiencies of the enzymes sulphite oxidase, xanthine dehydrogenase and aldehyde dehydrogenase) and isolated sulphite oxidase deficiency are inherited metabolic diseases which follow an autosomal recessive trait of inheritance. Detection of these diseases in selective screening for inborn errors of metabolism is not easy b...... hiện toàn bộ
Comparison of Seven Formulae and Isoelectrofocusing for Determination of Intrathecally Produced IgG in Neurological DiseasesAnnals of Clinical Biochemistry - Tập 29 Số 4 - Trang 405-410 - 1992
Sten Öhman, Jan Ernerudh, Pia Forsberg, Annemarie Henriksson, H. von Schenck, Magnus Vrethem
Seven different formulae and agarose isoelectrofocusing (AIF) using immunolabelling for IgG were compared for their ability to discriminate between intrathecally produced IgG and transudated IgG in cerebrospinal fluid. All reference limits were set to a specificity of 97·5% (reference group, n = 211). The probability of a positive test ( p+) was evaluated for 112 pati...... hiện toàn bộ
Effects of Long-Term Haemodialysis on Lipid, Lipoprotein and Apolipoprotein Levels of Black Patients with Chronic Renal FailureAnnals of Clinical Biochemistry - Tập 25 Số 3 - Trang 242-245 - 1988
Nader Rifai, Mary E. King, Domenic A. Sica
Premature coronary artery disease is believed to be a major cause of death in patients undergoing long-term haemodialysis. We investigated the effects of chronic maintenance haemodialysis on lipid, lipoprotein and apolipoprotein levels of 42 black patients with chronic renal failure and compared them with those of 40 age- and sex-matched black controls to determine the changes in the lipop...... hiện toàn bộ