Annals of Clinical Biochemistry

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The Use of Cytokine and C-Reactive Protein Measurements in Cerebrospinal Fluid during Acute Infective Meningitis
Annals of Clinical Biochemistry - Tập 31 Số 3 - Trang 255-261 - 1994
M Stearman, H J Southgate
Cerebrospinal fluid (CSF) concentrations of C-reactive protein (CRP), tumour necrosis factor α (TNF), interleukin-6 (IL-6), total protein (TP) and white cell count with differential (WCC) have been measured in 24 patients presenting with acute bacterial or viral meningitis and also in a non-infected, non-inflammed control group ( n = 24). In acute viral meningitis, CRP levels were not rai...... hiện toàn bộ
CSF levels of PSA and PSA–ACT complexes in Alzheimer's disease
Annals of Clinical Biochemistry - Tập 46 Số 6 - Trang 477-483 - 2009
Sandra D. Mulder, Johannes A. Heijst, Cees Mulder, Frans Martens, C. Erik Hack, Philip Scheltens, Marinus A. Blankenstein, Robert Veerhuis
Background Prostate-specific antigen (PSA) is a serine protease that in serum, is predominantly found complexed to the serine protease inhibitor alpha1-antichymotrypsin (ACT). ACT co-localizes with amyloid plaques in Alzheimer's disease (AD) brain and both PSA and ACT are detectable in cerebrospinal fluid (CSF). Therefore, we aimed to determine whether PS...... hiện toàn bộ
Biochemical Differences in Human Glomerular Basement Membrane Related to Diabetes and Age
Annals of Clinical Biochemistry - Tập 19 Số 1 - Trang 17-21 - 1982
A. De Bats, E.L. RHODES, A. H. Gordon, Dennis V. Parke
Preparations of glomerular basement membrane from diabetic and young and aged normal subjects have been isolated and purified and the component carbohydrates and amino acids quantitatively determined. Diabetic membrane preparations, compared with membranes from young normal subjects, show significant increases in total hexoses, mannose, and galactose and decreases in sialic acid and gluco...... hiện toàn bộ
3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon- γ
Annals of Clinical Biochemistry - Tập 38 Số 3 - Trang 242-251 - 2001
Toshiko Morita, Kuniaki Saito, Masao Takemura, Naoya Maekawa, Suwako Fujigaki, Hidehiko Fujii, Hisayasu Wada, Shoji Takeuchi, Akio Noma, Mitsuru Seishima
3-Hydroxyanthranilic acid (3-HAA), a metabolite of L-tryptophan, accumulates in monocyte-derived cells (THP-1),but not in other celllines tested(MRC9, H4, U373MG, Wil-NS), following immune stimulation that induces indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the L-tryptophan-kynurenine pathway. We examined whether metabolites of the L-tryptophan-kynurenine pathway act to i...... hiện toàn bộ
Quality of Performance of Assays for Maternal Serum Alphafetoprotein in the United Kingdom: Evidence from the UK External Quality Assessment Scheme 1980–87
Annals of Clinical Biochemistry - Tập 25 Số 3 - Trang 310-318 - 1988
Surajit Gorai, I Hanning, R R A Bacon, W. M. Hunter
Between-laboratory agreement in the UK EQAS for maternal serum alphafetoprotein has improved steadily since 1976 and the geometric coefficient of variation is now 8 to 9% at levels of 50 to 150 kU/L. The use of a common standard and commercial assay kits appear to have contributed to this trend. Within-laboratory performance is also generally good, about 50% of participants maintain a bia...... hiện toàn bộ
Bacterial Contamination of QC Specimens as a Cause of Artefactually Poor Performance in the UK EQAS
Annals of Clinical Biochemistry - Tập 24 Số 2 - Trang 182-184 - 1987
LaKeta Kemp, K M Ferguson, S.L. Jeffcoate
During 1984–85, users of a solid-phase radioimmunoassay kit for LH and FSH had problems of both variability and bias in the assay of some EQAS specimens despite adequate internal QC. The cause has been identified as contamination of these specimens with Pseudomonas fluorescens.
Improved Performance of Plasma Gonadotrophin Assays Using Common Reagents and Assay Protocols: Evidence from the UK External Quality Assessment Scheme
Annals of Clinical Biochemistry - Tập 22 Số 2 - Trang 179-184 - 1985
Margaret M. Hayes, K M Ferguson, S.L. Jeffcoate, R R A Bacon, Surajit Gorai
Radioimmunoassay kits prepared in the Chelsea Hospital for Women for follicle stimulating hormone (FSH) and luteinising hormone (LH) have been used in 26 UK laboratories for over 2 years. Data from the UK External Quality Assessment Schemes for FSH and LH have been used to provide an independent assessment of the performance of these kits over a 12-month period. For both...... hiện toàn bộ
Assays for Follicle Stimulating Hormone and Luteinising Hormone: Guidelines for the Provision of a Clinical Biochemistry Service
Annals of Clinical Biochemistry - Tập 24 Số 3 - Trang 246-262 - 1987
G.H. Beastall, K M Ferguson, Denis St J O’Reilly, Surajit Gorai, B. Sheridan
The measurement of serum follicle stimulating hormone (FSH) and luteinising hormone (LH), together with the appropriate sex steroid, is of great value in the investigation of delayed and precocious puberty, hypogonadism, subfertility, polycystic ovarian disease and hypothalamic-pituitary disorders. Dynamic function testing of the hypothalamic-pituitary-gonadal axis should be restricted to ...... hiện toàn bộ
LDLR gene synonymous mutation c.1813C>T results in mRNA splicing variation in a kindred with familial hypercholesterolaemia
Annals of Clinical Biochemistry - Tập 52 Số 6 - Trang 680-684 - 2015
Clement Ho, Fathel Rahman Musa, Christine Bell, Simon W. Walker
Familial hypercholesterolaemia, one of the most common inherited diseases in the general population, is associated with mutations in at least three different genes including the low density lipoprotein receptor ( LDLR), apolipoprotein B ( APOB) and protein convertase subtilisin/kexin type 9 ( PCSK9) genes. In this report, we describe an unclassified DNA variant (c.1813C>T; p.Leu605Leu)...... hiện toàn bộ
Chemiluminescence Immunoassay for Progesterone in Plasma Incorporating Acridinium Ester Labelled Antigen
Annals of Clinical Biochemistry - Tập 25 Số 1 - Trang 27-34 - 1988
Stuart Miller, Michael S. Scott Morton, A. Turkes
A sensitive, solid-phase chemiluminescence immunoassay suitable for determining progesterone concentrations in plasma has been developed. The solid-phase antiserum was prepared by coupling a monoclonal progesterone-antibody, raised against a progesterone-11α-hemisuccinyl/bovine serum albumin conjugate, to cyanogen bromide activated cellulose. An 11α-progesteryl-2-carboxymethyltyramine-4-(...... hiện toàn bộ
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