The Use of Cytokine and C-Reactive Protein Measurements in Cerebrospinal Fluid during Acute Infective MeningitisAnnals of Clinical Biochemistry - Tập 31 Số 3 - Trang 255-261 - 1994
M Stearman, H J Southgate
Cerebrospinal fluid (CSF) concentrations of C-reactive protein (CRP), tumour necrosis factor α (TNF), interleukin-6 (IL-6), total protein (TP) and white cell count with differential (WCC) have been measured in 24 patients presenting with acute bacterial or viral meningitis and also in a non-infected, non-inflammed control group ( n = 24). In acute viral meningitis, CRP levels were not rai...... hiện toàn bộ
CSF levels of PSA and PSA–ACT complexes in Alzheimer's diseaseAnnals of Clinical Biochemistry - Tập 46 Số 6 - Trang 477-483 - 2009
Sandra D. Mulder, Johannes A. Heijst, Cees Mulder, Frans Martens, C. Erik Hack, Philip Scheltens, Marinus A. Blankenstein, Robert Veerhuis
Background Prostate-specific antigen (PSA) is a serine protease that in serum, is predominantly found complexed to the serine protease inhibitor alpha1-antichymotrypsin (ACT). ACT co-localizes with amyloid plaques in Alzheimer's disease (AD) brain and both PSA and ACT are detectable in cerebrospinal fluid (CSF). Therefore, we aimed to determine whether PS...... hiện toàn bộ
Biochemical Differences in Human Glomerular Basement Membrane Related to Diabetes and AgeAnnals of Clinical Biochemistry - Tập 19 Số 1 - Trang 17-21 - 1982
A. De Bats, E.L. RHODES, A. H. Gordon, Dennis V. Parke
Preparations of glomerular basement membrane from diabetic and young and aged normal subjects have been isolated and purified and the component carbohydrates and amino acids quantitatively determined. Diabetic membrane preparations, compared with membranes from young normal subjects, show significant increases in total hexoses, mannose, and galactose and decreases in sialic acid and gluco...... hiện toàn bộ
3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon- γAnnals of Clinical Biochemistry - Tập 38 Số 3 - Trang 242-251 - 2001
Toshiko Morita, Kuniaki Saito, Masao Takemura, Naoya Maekawa, Suwako Fujigaki, Hidehiko Fujii, Hisayasu Wada, Shoji Takeuchi, Akio Noma, Mitsuru Seishima
3-Hydroxyanthranilic acid (3-HAA), a metabolite of L-tryptophan, accumulates in monocyte-derived cells (THP-1),but not in other celllines tested(MRC9, H4, U373MG, Wil-NS), following immune stimulation that induces indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the L-tryptophan-kynurenine pathway. We examined whether metabolites of the L-tryptophan-kynurenine pathway act to i...... hiện toàn bộ
Assays for Follicle Stimulating Hormone and Luteinising Hormone: Guidelines for the Provision of a Clinical Biochemistry ServiceAnnals of Clinical Biochemistry - Tập 24 Số 3 - Trang 246-262 - 1987
G.H. Beastall, K M Ferguson, Denis St J O’Reilly, Surajit Gorai, B. Sheridan
The measurement of serum follicle stimulating hormone (FSH) and luteinising hormone (LH), together with the appropriate sex steroid, is of great value in the investigation of delayed and precocious puberty, hypogonadism, subfertility, polycystic ovarian disease and hypothalamic-pituitary disorders. Dynamic function testing of the hypothalamic-pituitary-gonadal axis should be restricted to ...... hiện toàn bộ
LDLR gene synonymous mutation c.1813C>T results in mRNA splicing variation in a kindred with familial hypercholesterolaemiaAnnals of Clinical Biochemistry - Tập 52 Số 6 - Trang 680-684 - 2015
Clement Ho, Fathel Rahman Musa, Christine Bell, Simon W. Walker
Familial hypercholesterolaemia, one of the most common inherited diseases in the general population, is associated with mutations in at least three different genes including the low density lipoprotein receptor ( LDLR), apolipoprotein B ( APOB) and protein convertase subtilisin/kexin type 9 ( PCSK9) genes. In this report, we describe an unclassified DNA variant (c.1813C>T; p.Leu605Leu)...... hiện toàn bộ
Chemiluminescence Immunoassay for Progesterone in Plasma Incorporating Acridinium Ester Labelled AntigenAnnals of Clinical Biochemistry - Tập 25 Số 1 - Trang 27-34 - 1988
Stuart Miller, Michael S. Scott Morton, A. Turkes
A sensitive, solid-phase chemiluminescence immunoassay suitable for determining progesterone concentrations in plasma has been developed. The solid-phase antiserum was prepared by coupling a monoclonal progesterone-antibody, raised against a progesterone-11α-hemisuccinyl/bovine serum albumin conjugate, to cyanogen bromide activated cellulose. An 11α-progesteryl-2-carboxymethyltyramine-4-(...... hiện toàn bộ