Annals of Clinical Biochemistry
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3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon- γ
Annals of Clinical Biochemistry - Tập 38 Số 3 - Trang 242-251 - 2001
3-Hydroxyanthranilic acid (3-HAA), a metabolite of L-tryptophan, accumulates in
monocyte-derived cells (THP-1),but not in other celllines tested(MRC9, H4,
U373MG, Wil-NS), following immune stimulation that induces indoleamine
2,3-dioxygenase (IDO), a rate-limiting enzyme in the L-tryptophan-kynurenine
pathway. We examined whether metabolites of the L-tryptophan-kynurenine pathway
act to induce apo...
Bacterial Contamination of QC Specimens as a Cause of Artefactually Poor Performance in the UK EQAS
Annals of Clinical Biochemistry - Tập 24 Số 2 - Trang 182-184 - 1987
During 1984–85, users of a solid-phase radioimmunoassay kit for LH and FSH had
problems of both variability and bias in the assay of some EQAS specimens
despite adequate internal QC. The cause has been identified as contamination of
these specimens with Pseudomonas fluorescens.
Improved Performance of Plasma Gonadotrophin Assays Using Common Reagents and Assay Protocols: Evidence from the UK External Quality Assessment Scheme
Annals of Clinical Biochemistry - Tập 22 Số 2 - Trang 179-184 - 1985
Radioimmunoassay kits prepared in the Chelsea Hospital for Women for follicle
stimulating hormone (FSH) and luteinising hormone (LH) have been used in 26 UK
laboratories for over 2 years. Data from the UK External Quality Assessment
Schemes for FSH and LH have been used to provide an independent assessment of
the performance of these kits over a 12-month period. For both analytes, users
of the kit...
Quality of Performance of Assays for Maternal Serum Alphafetoprotein in the United Kingdom: Evidence from the UK External Quality Assessment Scheme 1980–87
Annals of Clinical Biochemistry - Tập 25 Số 3 - Trang 310-318 - 1988
Between-laboratory agreement in the UK EQAS for maternal serum alphafetoprotein
has improved steadily since 1976 and the geometric coefficient of variation is
now 8 to 9% at levels of 50 to 150 kU/L. The use of a common standard and
commercial assay kits appear to have contributed to this trend.
Within-laboratory performance is also generally good, about 50% of participants
maintain a bias of less...
Assays for Follicle Stimulating Hormone and Luteinising Hormone: Guidelines for the Provision of a Clinical Biochemistry Service
Annals of Clinical Biochemistry - Tập 24 Số 3 - Trang 246-262 - 1987
The measurement of serum follicle stimulating hormone (FSH) and luteinising
hormone (LH), together with the appropriate sex steroid, is of great value in
the investigation of delayed and precocious puberty, hypogonadism, subfertility,
polycystic ovarian disease and hypothalamic-pituitary disorders. Dynamic
function testing of the hypothalamic-pituitary-gonadal axis should be restricted
to a few de...
LDLR gene synonymous mutation c.1813C>T results in mRNA splicing variation in a kindred with familial hypercholesterolaemia
Annals of Clinical Biochemistry - Tập 52 Số 6 - Trang 680-684 - 2015
Familial hypercholesterolaemia, one of the most common inherited diseases in the
general population, is associated with mutations in at least three different
genes including the low density lipoprotein receptor ( LDLR), apolipoprotein B (
APOB) and protein convertase subtilisin/kexin type 9 ( PCSK9) genes. In this
report, we describe an unclassified DNA variant (c.1813C>T; p.Leu605Leu) within
exon...
Chemiluminescence Immunoassay for Progesterone in Plasma Incorporating Acridinium Ester Labelled Antigen
Annals of Clinical Biochemistry - Tập 25 Số 1 - Trang 27-34 - 1988
A sensitive, solid-phase chemiluminescence immunoassay suitable for determining
progesterone concentrations in plasma has been developed. The solid-phase
antiserum was prepared by coupling a monoclonal progesterone-antibody, raised
against a progesterone-11α-hemisuccinyl/bovine serum albumin conjugate, to
cyanogen bromide activated cellulose. An
11α-progesteryl-2-carboxymethyltyramine-4-(10-methyl...
New approaches towards laboratory diagnosis of isolated sulphite oxidase deficiency
Annals of Clinical Biochemistry - Tập 41 Số 2 - Trang 157-159 - 2004
Background: Molybdenum cofactor deficiency (resulting in combined deficiencies
of the enzymes sulphite oxidase, xanthine dehydrogenase and aldehyde
dehydrogenase) and isolated sulphite oxidase deficiency are inherited metabolic
diseases which follow an autosomal recessive trait of inheritance. Detection of
these diseases in selective screening for inborn errors of metabolism is not
easy because re...
Comparison of Seven Formulae and Isoelectrofocusing for Determination of Intrathecally Produced IgG in Neurological Diseases
Annals of Clinical Biochemistry - Tập 29 Số 4 - Trang 405-410 - 1992
Seven different formulae and agarose isoelectrofocusing (AIF) using
immunolabelling for IgG were compared for their ability to discriminate between
intrathecally produced IgG and transudated IgG in cerebrospinal fluid. All
reference limits were set to a specificity of 97·5% (reference group, n = 211).
The probability of a positive test ( p+) was evaluated for 112 patients with
multiple sclerosis (...
Effects of Long-Term Haemodialysis on Lipid, Lipoprotein and Apolipoprotein Levels of Black Patients with Chronic Renal Failure
Annals of Clinical Biochemistry - Tập 25 Số 3 - Trang 242-245 - 1988
Premature coronary artery disease is believed to be a major cause of death in
patients undergoing long-term haemodialysis. We investigated the effects of
chronic maintenance haemodialysis on lipid, lipoprotein and apolipoprotein
levels of 42 black patients with chronic renal failure and compared them with
those of 40 age- and sex-matched black controls to determine the changes in the
lipoprotein p...
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