Annals of Clinical Biochemistry

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3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon- γ
Annals of Clinical Biochemistry - Tập 38 Số 3 - Trang 242-251 - 2001
Toshiko Morita, Kuniaki Saito, Masao Takemura, Naoya Maekawa, Suwako Fujigaki, Hidehiko Fujii, Hisayasu Wada, Shoji Takeuchi, Akio Noma, Mitsuru Seishima
3-Hydroxyanthranilic acid (3-HAA), a metabolite of L-tryptophan, accumulates in monocyte-derived cells (THP-1),but not in other celllines tested(MRC9, H4, U373MG, Wil-NS), following immune stimulation that induces indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the L-tryptophan-kynurenine pathway. We examined whether metabolites of the L-tryptophan-kynurenine pathway act to i...... hiện toàn bộ
Quality of Performance of Assays for Maternal Serum Alphafetoprotein in the United Kingdom: Evidence from the UK External Quality Assessment Scheme 1980–87
Annals of Clinical Biochemistry - Tập 25 Số 3 - Trang 310-318 - 1988
Surajit Gorai, I Hanning, R R A Bacon, W. M. Hunter
Between-laboratory agreement in the UK EQAS for maternal serum alphafetoprotein has improved steadily since 1976 and the geometric coefficient of variation is now 8 to 9% at levels of 50 to 150 kU/L. The use of a common standard and commercial assay kits appear to have contributed to this trend. Within-laboratory performance is also generally good, about 50% of participants maintain a bia...... hiện toàn bộ
Bacterial Contamination of QC Specimens as a Cause of Artefactually Poor Performance in the UK EQAS
Annals of Clinical Biochemistry - Tập 24 Số 2 - Trang 182-184 - 1987
LaKeta Kemp, K M Ferguson, S.L. Jeffcoate
During 1984–85, users of a solid-phase radioimmunoassay kit for LH and FSH had problems of both variability and bias in the assay of some EQAS specimens despite adequate internal QC. The cause has been identified as contamination of these specimens with Pseudomonas fluorescens.
Improved Performance of Plasma Gonadotrophin Assays Using Common Reagents and Assay Protocols: Evidence from the UK External Quality Assessment Scheme
Annals of Clinical Biochemistry - Tập 22 Số 2 - Trang 179-184 - 1985
Margaret M. Hayes, K M Ferguson, S.L. Jeffcoate, R R A Bacon, Surajit Gorai
Radioimmunoassay kits prepared in the Chelsea Hospital for Women for follicle stimulating hormone (FSH) and luteinising hormone (LH) have been used in 26 UK laboratories for over 2 years. Data from the UK External Quality Assessment Schemes for FSH and LH have been used to provide an independent assessment of the performance of these kits over a 12-month period. For both...... hiện toàn bộ
Assays for Follicle Stimulating Hormone and Luteinising Hormone: Guidelines for the Provision of a Clinical Biochemistry Service
Annals of Clinical Biochemistry - Tập 24 Số 3 - Trang 246-262 - 1987
G.H. Beastall, K M Ferguson, Denis St J O’Reilly, Surajit Gorai, B. Sheridan
The measurement of serum follicle stimulating hormone (FSH) and luteinising hormone (LH), together with the appropriate sex steroid, is of great value in the investigation of delayed and precocious puberty, hypogonadism, subfertility, polycystic ovarian disease and hypothalamic-pituitary disorders. Dynamic function testing of the hypothalamic-pituitary-gonadal axis should be restricted to ...... hiện toàn bộ
LDLR gene synonymous mutation c.1813C>T results in mRNA splicing variation in a kindred with familial hypercholesterolaemia
Annals of Clinical Biochemistry - Tập 52 Số 6 - Trang 680-684 - 2015
Clement Ho, Fathel Rahman Musa, Christine Bell, Simon W. Walker
Familial hypercholesterolaemia, one of the most common inherited diseases in the general population, is associated with mutations in at least three different genes including the low density lipoprotein receptor ( LDLR), apolipoprotein B ( APOB) and protein convertase subtilisin/kexin type 9 ( PCSK9) genes. In this report, we describe an unclassified DNA variant (c.1813C>T; p.Leu605Leu)...... hiện toàn bộ
Chemiluminescence Immunoassay for Progesterone in Plasma Incorporating Acridinium Ester Labelled Antigen
Annals of Clinical Biochemistry - Tập 25 Số 1 - Trang 27-34 - 1988
Stuart Miller, Michael S. Scott Morton, A. Turkes
A sensitive, solid-phase chemiluminescence immunoassay suitable for determining progesterone concentrations in plasma has been developed. The solid-phase antiserum was prepared by coupling a monoclonal progesterone-antibody, raised against a progesterone-11α-hemisuccinyl/bovine serum albumin conjugate, to cyanogen bromide activated cellulose. An 11α-progesteryl-2-carboxymethyltyramine-4-(...... hiện toàn bộ
New approaches towards laboratory diagnosis of isolated sulphite oxidase deficiency
Annals of Clinical Biochemistry - Tập 41 Số 2 - Trang 157-159 - 2004
Jörn Oliver Sass, Toyofumi Nakanishi, Takako Sato, Akira Shimizu
Background: Molybdenum cofactor deficiency (resulting in combined deficiencies of the enzymes sulphite oxidase, xanthine dehydrogenase and aldehyde dehydrogenase) and isolated sulphite oxidase deficiency are inherited metabolic diseases which follow an autosomal recessive trait of inheritance. Detection of these diseases in selective screening for inborn errors of metabolism is not easy b...... hiện toàn bộ
Comparison of Seven Formulae and Isoelectrofocusing for Determination of Intrathecally Produced IgG in Neurological Diseases
Annals of Clinical Biochemistry - Tập 29 Số 4 - Trang 405-410 - 1992
Sten Öhman, Jan Ernerudh, Pia Forsberg, Annemarie Henriksson, H. von Schenck, Magnus Vrethem
Seven different formulae and agarose isoelectrofocusing (AIF) using immunolabelling for IgG were compared for their ability to discriminate between intrathecally produced IgG and transudated IgG in cerebrospinal fluid. All reference limits were set to a specificity of 97·5% (reference group, n = 211). The probability of a positive test ( p+) was evaluated for 112 pati...... hiện toàn bộ
Effects of Long-Term Haemodialysis on Lipid, Lipoprotein and Apolipoprotein Levels of Black Patients with Chronic Renal Failure
Annals of Clinical Biochemistry - Tập 25 Số 3 - Trang 242-245 - 1988
Nader Rifai, Mary E. King, Domenic A. Sica
Premature coronary artery disease is believed to be a major cause of death in patients undergoing long-term haemodialysis. We investigated the effects of chronic maintenance haemodialysis on lipid, lipoprotein and apolipoprotein levels of 42 black patients with chronic renal failure and compared them with those of 40 age- and sex-matched black controls to determine the changes in the lipop...... hiện toàn bộ
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