Annals of Clinical Biochemistry

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Quality of Performance of Assays for Maternal Serum Alphafetoprotein in the United Kingdom: Evidence from the UK External Quality Assessment Scheme 1980–87
Annals of Clinical Biochemistry - Tập 25 Số 3 - Trang 310-318 - 1988
Surajit Gorai, I Hanning, R R A Bacon, W. M. Hunter
Between-laboratory agreement in the UK EQAS for maternal serum alphafetoprotein has improved steadily since 1976 and the geometric coefficient of variation is now 8 to 9% at levels of 50 to 150 kU/L. The use of a common standard and commercial assay kits appear to have contributed to this trend. Within-laboratory performance is also generally good, about 50% of participants maintain a bia...... hiện toàn bộ
Bacterial Contamination of QC Specimens as a Cause of Artefactually Poor Performance in the UK EQAS
Annals of Clinical Biochemistry - Tập 24 Số 2 - Trang 182-184 - 1987
LaKeta Kemp, K M Ferguson, S.L. Jeffcoate
During 1984–85, users of a solid-phase radioimmunoassay kit for LH and FSH had problems of both variability and bias in the assay of some EQAS specimens despite adequate internal QC. The cause has been identified as contamination of these specimens with Pseudomonas fluorescens.
Utility of the urine calcium-to-creatinine ratio to diagnose primary hyperparathyroidism in asymptomatic hypercalcaemic patients with vitamin D deficiency
Annals of Clinical Biochemistry - Tập 48 Số 2 - Trang 126-129 - 2011
Channa N. Jayasena, Mohammad Mahmud, Fausto Palazzo, Mandy Donaldson, Karim Meeran, Waljit S. Dhillo
Background Primary hyperparathyroidism (PHP) is the most common cause of hypercalcaemia, and often requires surgical treatment. Familial hypocalciuric hypercalcaemia (FHH) has similar biochemical features to PHP, but requires no treatment. The most common biochemical method used to distinguish between PHP and FHH is the urine calcium-to-creatinine ratio (...... hiện toàn bộ
Determination of Serum γ-Glutamyl Transpeptidase Activity and its Clinical Applications
Annals of Clinical Biochemistry - Tập 7 Số 6 - Trang 143-147 - 1970
S B Rosalki, Donald C. Rau, Deborah Lehmann, Mary Prentice
Factors Influencing the Assay of Creatinine
Annals of Clinical Biochemistry - Tập 12 Số 1-6 - Trang 219-232 - 1975
John G. Cook
The Use of Cytokine and C-Reactive Protein Measurements in Cerebrospinal Fluid during Acute Infective Meningitis
Annals of Clinical Biochemistry - Tập 31 Số 3 - Trang 255-261 - 1994
M Stearman, H J Southgate
Cerebrospinal fluid (CSF) concentrations of C-reactive protein (CRP), tumour necrosis factor α (TNF), interleukin-6 (IL-6), total protein (TP) and white cell count with differential (WCC) have been measured in 24 patients presenting with acute bacterial or viral meningitis and also in a non-infected, non-inflammed control group ( n = 24). In acute viral meningitis, CRP levels were not rai...... hiện toàn bộ
Plasma Carnitine Reference Values
Annals of Clinical Biochemistry - Tập 31 Số 2 - Trang 188-189 - 1994
M. Farriol, S. Schwartz
CSF levels of PSA and PSA–ACT complexes in Alzheimer's disease
Annals of Clinical Biochemistry - Tập 46 Số 6 - Trang 477-483 - 2009
Sandra D. Mulder, Johannes A. Heijst, Cees Mulder, Frans Martens, C. Erik Hack, Philip Scheltens, Marinus A. Blankenstein, Robert Veerhuis
Background Prostate-specific antigen (PSA) is a serine protease that in serum, is predominantly found complexed to the serine protease inhibitor alpha1-antichymotrypsin (ACT). ACT co-localizes with amyloid plaques in Alzheimer's disease (AD) brain and both PSA and ACT are detectable in cerebrospinal fluid (CSF). Therefore, we aimed to determine whether PS...... hiện toàn bộ
The Measurement of Insulin-Like Growth Factor I: Clinical Applications and Significance
Annals of Clinical Biochemistry - Tập 23 Số 4 - Trang 413-424 - 1986
J D Teale, Vincent Marks
Of the somatomedins so far measured, the selective quantitation of insulin-like growth factor I (IGF-I) appears to have the greatest potential in clinical diagnosis. There have been two approaches to the development of immunoassay systems. One type uses antibodies raised against synthetic fragments of IGF-I which exhibit cross-reactivity with the whole hormone. Such assay systems may be ad...... hiện toàn bộ
Biochemical Differences in Human Glomerular Basement Membrane Related to Diabetes and Age
Annals of Clinical Biochemistry - Tập 19 Số 1 - Trang 17-21 - 1982
A. De Bats, E.L. RHODES, A. H. Gordon, Dennis V. Parke
Preparations of glomerular basement membrane from diabetic and young and aged normal subjects have been isolated and purified and the component carbohydrates and amino acids quantitatively determined. Diabetic membrane preparations, compared with membranes from young normal subjects, show significant increases in total hexoses, mannose, and galactose and decreases in sialic acid and gluco...... hiện toàn bộ
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