Amino Acids
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Combinatorial peptide libraries to overcome the classical affinity-enrichment methods in proteomics
Amino Acids - Tập 45 - Trang 219-229 - 2013
The enrichment of targeted low-abundance proteins is possible by affinity adsorption using selected sorbents. Different categories of very dilute proteins are present in most of biological extracts so that specific affinity methods are unable to address their collective enrichment. Only recently an interesting approach has been proposed associating the affinity of multiple ligands used as a librar...... hiện toàn bộ
Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update. Part II: synthetic uses of ethynylglycine synthon
Amino Acids - Tập 50 Số 10 - Trang 1307-1328 - 2018
The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyl-oxazolidine} is a chiral compound with valuable synthetic interest. An update (covering literature from 2005 to 2017) on the different synthetic utilities is reviewed and discussed.
An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts
Amino Acids - - Trang 1-7 - 2023
In the human body, the skin is one of the organs most affected by the aging process. Nutritional approaches aimed to counteract the age-induced decline of extracellular matrix (ECM) deposition could be a valuable tool to decrease the degenerative processes underlying skin aging. Here, we investigated the ability of a six-amino acid plus hyaluronic acid (6AAH) formulation enriched with tricarboxyli...... hiện toàn bộ
A conjugate of the lytic peptide Hecate and gallic acid: structure, activity against cervical cancer, and toxicity
Amino Acids - Tập 47 - Trang 1433-1443 - 2015
Conjugate compounds constitute a new class of molecules
of important biological interest mainly for the treatment of diseases such as cancer. The N-terminus region of cationic peptides has been described as important for their biological activity. The aim of this study was to evaluate the lytic peptide Hecate (FALALKALKKALKKLKKALKKAL) and the effect of conjugating this macromolecule with gallic a...... hiện toàn bộ
A new 18F-labeled BBN-RGD peptide heterodimer with a symmetric linker for prostate cancer imaging
Amino Acids - Tập 41 - Trang 439-447 - 2010
A peptide heterodimer comprises two different receptor-targeting peptide ligands. Molecular imaging probes based on dual-receptor targeting peptide heterodimers exhibit improved tumor targeting efficacy for multi-receptor expressing tumors compared with their parent single-receptor targeting peptide monomers. Previously we have developed bombesin (BBN)-RGD (Arg-Gly-Asp) peptide heterodimers, in wh...... hiện toàn bộ
Design and synthesis of a novel anthracene-based fluorescent probe through the application of the Suzuki–Miyaura cross-coupling reaction
Amino Acids - Tập 35 - Trang 169-173 - 2007
We report on a simple synthetic route to a novel anthracene-based bis-armed amino acid derivative as a useful fluorescent probe. Various photophysical studies of this amino acid derivative are also described. Here, Suzuki–Miyaura cross-coupling reaction has been used as a key step for carbon–carbon bond formation.
Taurine supplementation in high-fat diet fed male mice attenuates endocrine pancreatic dysfunction in their male offspring
Amino Acids - - 2019
A direct method for the synthesis of orthogonally protected furyl- and thienyl- amino acids
Amino Acids - Tập 47 - Trang 779-785 - 2015
The synthesis of unnatural amino acids plays a key part in expanding the potential application of peptide-based drugs and in the total synthesis of peptide natural products. Herein, we report a direct method for the synthesis of orthogonally protected 5-membered heteroaromatic amino acids.
Taurine prevents fat deposition and ameliorates plasma lipid profile in monosodium glutamate-obese rats
Amino Acids - Tập 41 - Trang 901-908 - 2010
The aim of the present study was to evaluate the preventive effects of taurine (TAU) supplementation upon monosodium glutamate (MSG)-induced obesity. Rats treated during the first 5 days of life with MSG or saline were distributed into the following groups: control (CTL), CTL-treated with TAU (CTAU), MSG and MSG-supplemented with TAU (MTAU). CTAU and MTAU received 2.5% of TAU in their drinking wat...... hiện toàn bộ
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