Amino Acids

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Tryptophan metabolism, from nutrition to potential therapeutic applications
Amino Acids - Tập 41 - Trang 1195-1205 - 2010
Nathalie Le Floc’h, Winfried Otten, Elodie Merlot
Tryptophan is an indispensable amino acid that should to be supplied by dietary protein. Apart from its incorporation into body proteins, tryptophan is the precursor for serotonin, an important neuromediator, and for kynurenine, an intermediary metabolite of a complex metabolic pathway ending with niacin, CO2, and kynurenic and xanthurenic acids. Tryptophan metabolism within different tissues is a...... hiện toàn bộ
Polyamine oxidase activity in rats treated with mitoguazone: Specific and permanent decrease in thymus
Amino Acids - Tập 24 - Trang 187-194 - 2003
M. E. Ferioli, A. Armanni
To extend the knowledge on the role of polyamine oxidase in thymus physiology, we evaluated the in vivo effect of the polyamine biosynthetic pathway inhibitor mitoguazone. The drug markedly and permanently decreased the enzyme activity in the organ, in which the level of putrescine also decreased at the later times observed. A byproduct of the reaction catalyzed by polyamine oxidase is hydrogen p...... hiện toàn bộ
Functional characterization of brain mitochondrial nitric oxide synthase during hypertension and aging
Amino Acids - Tập 30 - Trang 73-80 - 2005
E. Calderón-Cortés, M Clemente-Guerrero, E. Sierra-Campos, C. Cortés-Rojo, F. J. Gaona-Zamudio, R. Villalobos-Molina, A. Saavedra-Molina
Nitric oxide (NO•) plays an important role in various physiological processes. The aim of the present study was to investigate if brain mitochondrial nitric oxide synthase (mtNOS) is active and functional during hypertension. L-citrulline production, an indicator of nitric oxide synthesis, was concentration-dependent on L-arginine in all strains and all ages tested, and was inhibited by 7-Nitroind...... hiện toàn bộ
Polyamines and transglutaminase activity are involved in compatible and self-incompatible pollination of Citrus grandis
Amino Acids - Tập 42 - Trang 1025-1035 - 2011
Alessandra Gentile, Fabiana Antognoni, Rosa Anna Iorio, Gaetano Distefano, Giuseppina Las Casas, Stefano La Malfa, Donatella Serafini-Fracassini, Stefano Del Duca
Pollination of pummelo (Citrus grandis L. Osbeck) pistils has been studied in planta by adding compatible and self-incompatible (SI) pollen to the stigma surface. The pollen germination has been monitored inside the pistil by fluorescent microscopy showing SI altered morphologies with irregular depositions of callose in the tube walls, and heavy callose depositions in enlarged tips. The polyamine ...... hiện toàn bộ
Ảnh hưởng của việc thay thế glutamine bằng lysine đối với các đặc tính cấu trúc và sinh học của peptide kháng khuẩn Polybia-MP1 Dịch bởi AI
Amino Acids - Tập 55 - Trang 881-890 - 2023
Hai Bui Thi Phuong, Van Anh Tran, Khoa Nguyen Ngoc, Viet Nguyen Huu, Hang Ngo Thu, Mao Can Van, Hue Pham Thi, Minh Nguyen Hong, Hiep Tuan Tran, Huy Luong Xuan
Peptide kháng khuẩn tự nhiên Polybia-MP1 là ứng cử viên triển vọng cho việc phát triển các liệu pháp điều trị mới cho nhiễm trùng và ung thư. Nó thể hiện hoạt tính kháng khuẩn và chống ung thư phổ rộng với độ an toàn cao trên các tế bào khỏe mạnh. Tuy nhiên, các sửa đổi trình tự trước đây thường dẫn đến ít nhất một trong hai hậu quả: gia tăng đáng kể hoạt tính ly giải hồng cầu hoặc giảm đáng kể ho...... hiện toàn bộ
#Polybia-MP1 #peptide kháng khuẩn #glutamine #lysine #hoạt tính kháng khuẩn #hoạt tính chống ung thư
Methionine restriction on lipid metabolism and its possible mechanisms
Amino Acids - Tập 48 - Trang 1533-1540 - 2016
Xihong Zhou, Liuqin He, Dan Wan, Huansheng Yang, Kang Yao, Guoyao Wu, Xin Wu, Yulong Yin
Methionine restriction (MR) exerts many beneficial effects, such as increasing longevity, decreasing oxidative damage and alleviating inflammatory responses. Much attention has been recently focused on the effects of MR on metabolic health, especially lipid metabolism, since the increasing incidence of obesity, insulin resistance and type 2 diabetes causes a worldwide health problem. In general, M...... hiện toàn bộ
Addendum to 11th International Congress on Amino Acids, Peptides and Proteins
Amino Acids - Tập 37 - Trang 761-766 - 2009
SANA: an algorithm for sequential and non-sequential protein structure alignment
Amino Acids - Tập 39 - Trang 417-425 - 2010
Lin Wang, Ling-Yun Wu, Yong Wang, Xiang-Sun Zhang, Luonan Chen
Protein structure alignment algorithms play an important role in the studies of protein structure and function. In this paper, a novel approach for structure alignment is presented. Specifically, core regions in two protein structures are first aligned by identifying connected components in a network of neighboring geometrically compatible aligned fragment pairs. The initial alignments then are re...... hiện toàn bộ
Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance in Escherichia coli
Amino Acids - Tập 46 - Trang 661-670 - 2013
Yusuke Terui, Sunil D. Saroj, Akihiko Sakamoto, Taketo Yoshida, Kyohei Higashi, Shin Kurihara, Hideyuki Suzuki, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi
Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was higher than that of E. coli 3131 transformed with pACYC-PuuP when cells were cultured...... hiện toàn bộ
Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer
Amino Acids - Tập 53 - Trang 73-88 - 2021
Merve Celik Tekeli, Yesim Aktas, Nevin Celebi
The objective of this study was to prepare a stable self-nanoemulsifying formulation of exendin-4, which is an antidiabetic peptide. As exendin-4 is commercially available only in subcutaneous form, several attempts have been made to discover an effective oral formulation. Self-nanoemulsifying drug delivery systems are known to be suitable carriers for the oral administration of peptide drugs. Var...... hiện toàn bộ
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