American Journal of Physiology - Lung Cellular and Molecular Physiology

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Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 278 Số 5 - Trang L1008-L1017 - 2000
Conor Woods, Gerald G. Neslund, Elisabeth S. Kornbrust, Stephen F. Flaim
Infiltration of activated neutrophils into the lung appears to be a key element in the severe lung injury that develops in animal models of acute lung injury. Partial liquid ventilation with perflubron has been shown to ameliorate tissue damage compared with conventional mechanical ventilation in acute lung injury models. Pilot experiments indicated that indirect exposure to perflubron cou...... hiện toàn bộ
Activation of type II alveolar epithelial cells during acute endotoxemia
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 282 Số 4 - Trang L872-L880 - 2002
Vasanthi R. Sunil, Agnieszka J. Connor, Yan Guo, Jeffrey D. Laskin, Debra L. Laskin
Lung injury induced by acute endotoxemia is associated with increased generation of inflammatory mediators such as nitric oxide and eicosanoids, which have been implicated in the pathophysiological process. Although production of these mediators by alveolar macrophages (AM) has been characterized, the response of type II cells is unknown and was assessed in the present studies. Acute endot...... hiện toàn bộ
Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 294 Số 6 - Trang L1049-L1054 - 2008
Kristina L. Bailey, Jill Poole, T. Mathisen, Todd A. Wyatt, Susanna G. Von Essen, Debra J. Romberger
Hog confinement workers are at high risk to develop chronic bronchitis as a result of their exposure to organic dust. Chronic bronchitis is characterized by inflammatory changes of the airway epithelium. A key mediator in inflammation is Toll-like receptor 2 (TLR2). We investigated the role of TLR2 in pulmonary inflammation induced by hog confinement dust. Normal human bronchial epithelia...... hiện toàn bộ
Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturation
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 297 Số 4 - Trang L767-L776 - 2009
Jill Poole, Geoffrey M. Thiele, Neil E. Alexis, Angela Burrell, Conrad Parks, Debra J. Romberger
Organic dust exposure in agricultural animal environments results in airway diseases. Dendritic cells (DCs) orchestrate inflammatory immune response in the airways, but little is known about how organic dust affects differentiation and maturation of monocyte-derived immature and mature DCs (iDCs, mDCs). Peripheral blood monocytes were differentiated in vitro into iDCs with granulocyte-mac...... hiện toàn bộ
Organic dust augments nucleotide-binding oligomerization domain expression via an NF-κB pathway to negatively regulate inflammatory responses
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 301 Số 3 - Trang L296-L306 - 2011
Jill Poole, Tammy Kielian, Todd A. Wyatt, Angela Gleason, Jeremy Stone, Kelsey Palm, William W. West, Debra J. Romberger
Nucleotide-binding oligomerization domain 2 (NOD2) is involved in innate immune responses to peptidoglycan degradation products. Peptidoglycans are important mediators of organic dust-induced airway diseases in exposed agriculture workers; however, the role of NOD2 in response to complex organic dust is unknown. Monocytes/macrophages were exposed to swine facility organic dust extract (OD...... hiện toàn bộ
Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 296 Số 6 - Trang L1085-L1095 - 2009
Jill Poole, Todd A. Wyatt, Peter J. Oldenburg, Margaret K. Elliott, William W. West, Joseph H. Sisson, Susanna G. Von Essen, Debra J. Romberger
Organic dust exposure in agricultural environments results in an inflammatory response that attenuates over time, but repetitive exposures can result in chronic respiratory disease. Animal models to study these mechanisms are limited. This study investigated the effects of single vs. repetitive dust-induced airway inflammation in mice by intranasal exposure method. Mice were exposed to swi...... hiện toàn bộ
Regulation of angiopoietin expression by bacterial lipopolysaccharide
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 294 Số 5 - Trang L955-L963 - 2008
Mahroo Mofarrahi, Thamer Nouh, Salman T. Qureshi, Loïc Guillot, Dominique Mayaki, Sabah N. A. Hussain
Angiopoietins are ligands for Tie-2 receptors and play important roles in angiogenesis and inflammation. While angiopoietin-1 (Ang-1) inhibits inflammatory responses, angiopoietin-2 (Ang-2) promotes cytokine production and vascular leakage. In this study, we evaluated in vivo and in vitro effects of Escherichia coli lipopolysaccharides (LPS) on angiopoietin expression. Wild-type C57/BL6 m...... hiện toàn bộ
Microvascular endowment in the developing chicken embryo lung
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 292 Số 5 - Trang L1136-L1146 - 2007
Andrew N. Makanya, Ruslan Hlushchuk, Oliver Baum, N. Velinov, Mark W. Ochs, Valentin Djonov
In the current study, the contribution of the major angiogenic mechanisms, sprouting and intussusception, to vascular development in the avian lung has been demonstrated. Sprouting guides the emerging vessels to form the primordial vascular plexus, which successively surrounds and encloses the parabronchi. Intussusceptive angiogenesis has an upsurge from embryonic day 15 (E15) and contrib...... hiện toàn bộ
Hypoxia-induced reactive oxygen species downregulate ETBreceptor-mediated contraction of rat pulmonary arteries
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 290 Số 3 - Trang L570-L578 - 2006
Xiaohua Wang, Mei Song Tong, Shashi Chinta, J. Usha Raj, Yuansheng Gao
Production of reactive oxygen species (ROS) may be increased during hypoxia in pulmonary arteries. In this study, the role of ROS in the effect of hypoxia on endothelin (ET) type B (ETB) receptor-mediated vasocontraction in lungs was determined. In rat intrapulmonary (∼0.63 mm ID) arteries, contraction induced by IRL-1620 (a selective ETBreceptor a...... hiện toàn bộ
Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide
American Journal of Physiology - Lung Cellular and Molecular Physiology - Tập 298 Số 6 - Trang L880-L887 - 2010
Jong‐Hau Hsu, Peter Oishi, Dean A. Wiseman, Yali Hou, Omar Chikovani, Sanjeev A. Datar, Enikö Sajti, Michael Johengen, Cynthia Harmon, Stephen M. Black, Jeffrey R. Fineman
Acute partial compression of the fetal ductus arteriosus (DA) results in an initial abrupt increase in pulmonary blood flow (PBF), which is followed by a significant reduction in PBF to baseline values over the ensuing 2–4 h. We have previously demonstrated that this potent vasoconstricting response is due, in part, to an endothelin-1 (ET-1)-mediated decrease in nitric oxide synthase (NOS...... hiện toàn bộ
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