American Journal of Physiology - Lung Cellular and Molecular Physiology
SCIE-ISI SCOPUS (1989-2025)
1522-1504
1040-0605
Mỹ
Cơ quản chủ quản: AMER PHYSIOLOGICAL SOC , American Physiological Society
Lĩnh vực:
Physiology (medical)Cell BiologyPhysiologyPulmonary and Respiratory Medicine
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Reactive oxygen species in cell signaling
Tập 279 Số 6 - Trang L1005-L1028 - 2000
Reactive oxygen species (ROS) are generated as by-products of cellular
metabolism, primarily in the mitochondria. When cellular production of ROS
overwhelms its antioxidant capacity, damage to cellular macromolecules such as
lipids, protein, and DNA may ensue. Such a state of “oxidative stress” is
thought to contribute to the pathogenesis of a number of human diseases
including those of the lung. ...
Heme oxygenase: colors of defense against cellular stress
Tập 279 Số 6 - Trang L1029-L1037 - 2000
The discovery of the gaseous molecule nitric oxide in 1987 unraveled
investigations on its functional role in the pathogenesis of a wide spectrum of
biological and pathological processes. At that time, the novel concept that an
endogenous production of a gaseous substance such as nitric oxide can impart
such diverse and potent cellular effects proved to be very fruitful in enhancing
our understand...
NF-κB activation as a pathological mechanism of septic shock and inflammation
Tập 290 Số 4 - Trang L622-L645 - 2006
The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to
the activation of these networks. The role of NF-κB in septic pathophysiology
and the signal transduction pathways leading to NF-κB activation during sepsis
have been an area of intensive investigation. NF-κB is activated by a variety of
pathog...
Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases
Tập 284 Số 4 - Trang L566-L577 - 2003
Fifteen years have passed since the first description of interleukin
(IL)-8/CXCL8 as a potent neutrophil chemotactic factor. Accumulating evidence
has demonstrated that various types of cells can produce a large amount of
IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory
cytokines, microbes and their products, and environmental changes such as
hypoxia, reperfusion, and...
Animal models of chronic obstructive pulmonary disease
Tập 295 Số 1 - Trang L1-L15 - 2008
The mechanisms involved in the genesis of chronic obstructive pulmonary disease
(COPD) are poorly defined. This area is complicated and difficult to model
because COPD consists of four separate anatomic lesions (emphysema, small airway
remodeling, pulmonary hypertension, and chronic bronchitis) and a functional
lesion, acute exacerbation; moreover, the disease in humans develops over
decades. This...
TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?
Tập 279 Số 3 - Trang L562-L574 - 2000
Fibroblast proliferation and extracellular matrix accumulation characterize
idiopathic pulmonary fibrosis (IPF). We evaluated the presence of tissue
inhibitor of metalloproteinase (TIMP)-1, -2, -3, and -4; collagenase-1, -2, and
-3; gelatinases A and B; and membrane type 1 matrix metalloproteinase (MMP) in
12 IPF and 6 control lungs. TIMP-1 was found in interstitial macrophages and
TIMP-2 in fibro...
Biological significance of nitric oxide-mediated protein modifications
Tập 287 Số 2 - Trang L262-L268 - 2004
Nitric oxide (NO), despite an apparently simple diatomic structure, has a wide
variety of functions in both physiology and pathology and within every major
organ system. It has become an increasingly important scientific challenge to
decipher how this wide range of activity is achieved. To this end a number of
investigators have begun to explore how NO-mediated posttranslational
modifications of p...
Mechanisms of cigarette smoke-induced COPD: insights from animal models
Tập 294 Số 4 - Trang L612-L631 - 2008
Cigarette smoke-induced animal models of chronic obstructive pulmonary disease
support the protease-antiprotease hypothesis of emphysema, although which cells
and proteases are the crucial actors remains controversial. Inhibition of either
serine or metalloproteases produces significant protection against emphysema,
but inhibition is invariably accompanied by decreases in the inflammatory
response...
Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
Tập 278 Số 2 - Trang L312-L319 - 2000
Heme oxygenase (HO)-1 catalyzes the oxidative cleavage of heme to yield
equimolar amounts of biliverdin, iron, and carbon monoxide. HO-1 is a stress
response protein, the induction of which is associated with protection against
oxidative stress. The mechanism(s) of protection is not completely elucidated,
although it is suggested that one or more of the catalytic by-products provide
antioxidant fu...
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
Tập 278 Số 1 - Trang L193-L201 - 2000
Mast cells play a potentially important role in fibroproliferative diseases,
releasing mediators including tryptase that are capable of stimulating
fibroblast proliferation and procollagen synthesis. The mechanism by which
tryptase stimulates fibroblast proliferation is unclear, although recent studies
suggest it can activate protease-activated receptor (PAR)-2. We therefore
investigated the role ...