American Journal of Physiology - Lung Cellular and Molecular Physiology
SCIE-ISI SCOPUS (1989-2023)
1522-1504
1040-0605
Mỹ
Cơ quản chủ quản: AMER PHYSIOLOGICAL SOC , American Physiological Society
Lĩnh vực:
Physiology (medical)Cell BiologyPhysiologyPulmonary and Respiratory Medicine
Các bài báo tiêu biểu
Reactive oxygen species in cell signalingReactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA may ensue. Such a state of “oxidative stress” is thought to contribute to the pathogenesis of a number of human diseases including those of th... ... hiện toàn bộ
Tập 279 Số 6 - Trang L1005-L1028 - 2000
Heme oxygenase: colors of defense against cellular stressThe discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its functional role in the pathogenesis of a wide spectrum of biological and pathological processes. At that time, the novel concept that an endogenous production of a gaseous substance such as nitric oxide can impart such diverse and potent cellular effects proved to be very fruitful in enhancing our un... ... hiện toàn bộ
Tập 279 Số 6 - Trang L1029-L1037 - 2000
NF-κB activation as a pathological mechanism of septic shock and inflammationThe pathophysiology of sepsis and septic shock involves complex cytokine and inflammatory mediator networks. NF-κB activation is a central event leading to the activation of these networks. The role of NF-κB in septic pathophysiology and the signal transduction pathways leading to NF-κB activation during sepsis have been an area of intensive investigation. NF-κB is activated by a variety o... ... hiện toàn bộ
Tập 290 Số 4 - Trang L622-L645 - 2006
Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseasesFifteen years have passed since the first description of interleukin (IL)-8/CXCL8 as a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfus... ... hiện toàn bộ
Tập 284 Số 4 - Trang L566-L577 - 2003
Animal models of chronic obstructive pulmonary diseaseThe mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD) are poorly defined. This area is complicated and difficult to model because COPD consists of four separate anatomic lesions (emphysema, small airway remodeling, pulmonary hypertension, and chronic bronchitis) and a functional lesion, acute exacerbation; moreover, the disease in humans develops over decad... ... hiện toàn bộ
Tập 295 Số 1 - Trang L1-L15 - 2008
TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?Fibroblast proliferation and extracellular matrix accumulation characterize idiopathic pulmonary fibrosis (IPF). We evaluated the presence of tissue inhibitor of metalloproteinase (TIMP)-1, -2, -3, and -4; collagenase-1, -2, and -3; gelatinases A and B; and membrane type 1 matrix metalloproteinase (MMP) in 12 IPF and 6 control lungs. TIMP-1 was found in interstitial macrophages and TIMP-2 ... ... hiện toàn bộ
Tập 279 Số 3 - Trang L562-L574 - 2000
Biological significance of nitric oxide-mediated protein modificationsNitric oxide (NO), despite an apparently simple diatomic structure, has a wide variety of functions in both physiology and pathology and within every major organ system. It has become an increasingly important scientific challenge to decipher how this wide range of activity is achieved. To this end a number of investigators have begun to explore how NO-mediated posttranslational modificati... ... hiện toàn bộ
Tập 287 Số 2 - Trang L262-L268 - 2004
Mechanisms of cigarette smoke-induced COPD: insights from animal modelsCigarette smoke-induced animal models of chronic obstructive pulmonary disease support the protease-antiprotease hypothesis of emphysema, although which cells and proteases are the crucial actors remains controversial. Inhibition of either serine or metalloproteases produces significant protection against emphysema, but inhibition is invariably accompanied by decreases in the inflammatory ... ... hiện toàn bộ
Tập 294 Số 4 - Trang L612-L631 - 2008
Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblastsHeme oxygenase (HO)-1 catalyzes the oxidative cleavage of heme to yield equimolar amounts of biliverdin, iron, and carbon monoxide. HO-1 is a stress response protein, the induction of which is associated with protection against oxidative stress. The mechanism(s) of protection is not completely elucidated, although it is suggested that one or more of the catalytic by-products provide antiox... ... hiện toàn bộ
Tập 278 Số 2 - Trang L312-L319 - 2000
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2Mast cells play a potentially important role in fibroproliferative diseases, releasing mediators including tryptase that are capable of stimulating fibroblast proliferation and procollagen synthesis. The mechanism by which tryptase stimulates fibroblast proliferation is unclear, although recent studies suggest it can activate protease-activated receptor (PAR)-2. We therefore investigated t... ... hiện toàn bộ
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