American Journal of Physiology - Gastrointestinal and Liver Physiology

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Regulation of gastric epithelial cell development revealed in H+/K+-ATPase β-subunit- and gastrin-deficient mice
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 281 Số 6 - Trang G1502-G1511 - 2001
Teo V. Franic, Louise M. Judd, David Robinson, Simon P. Barrett, Katrina L. Scarff, Paul A. Gleeson, Linda C. Samuelson, Ian R. van Driel
The gastric H+/K+-ATPase is essential for normal development of parietal cells. Here we have directly assessed the role of the H+/K+-ATPase β-subunit (H/K-β) on epithelial cell development by detailed quantitation of the epithelial cell types of the gastric mucosa of H/K-β-deficient mice. H/K-β-deficient mi...... hiện toàn bộ
The role of luminal factors in the recovery of gastric function and behavioral changes after chronicHelicobacter pyloriinfection
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 295 Số 4 - Trang G664-G670 - 2008
Elena F. Verdú, Přemysl Berčík, Xian Xi Huang, Jun Lü, Nafia Al-Mutawaly, Hiromi Sakai, Thomas A. Tompkins, Kenneth Croitoru, Eihun Tsuchida, Mary H. Perdue, Stephen M. Collins
The role of chronic infections, such as Helicobacter pylori ( Hp), to produce sustained changes in host physiology remains controversial. In this study, we investigate whether the antigenic or bacterial content of the gut, after Hp eradication, influences the changes in gut function induced by chronic Hp infection. Mice were infected with Hp for 4 mo and then treated with antibiotics or pl...... hiện toàn bộ
A novel ultrasound technique to study the biomechanics of the human esophagus in vivo
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 282 Số 5 - Trang G785-G793 - 2002
Tomoshiro Takeda, Ghassan S. Kassab, Jianmin Liu, James L. Puckett, Rishi R. Mittal, Ravinder K. Mittal
The objectives of this study were to validate a novel ultrasound technique and to use it to study the circumferential stress-strain properties of the human esophagus in vivo. A manometric catheter equipped with a high-compliance bag and a high-frequency intraluminal ultrasonography probe was used to record esophageal pressure and images. Validation studies were performed in vitro followed...... hiện toàn bộ
Ca2+sparks and BK currents in gallbladder myocytes: role in CCK-induced response
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 282 Số 1 - Trang G165-G174 - 2002
Marı́a J. Pozo, Guillermo J. Pérez, Mark T. Nelson, Gary M. Mawe
We sought to elucidate the regulation of gallbladder smooth muscle (GBSM) excitability by localized Ca2+release events (sparks) and large-conductance Ca2+-dependent (BK) channels by determining whether sparks exist in GBSM and, if so, whether they activate BK channels. Sparks were identified in isolated GBSM loaded with fluo 4. Each spark was assoc...... hiện toàn bộ
Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 279 Số 4 - Trang G815-G826 - 2000
Sanjeev Gupta, Pankaj Rajvanshi, Harmeet Malhi, Sanjeev Slehria, Rana P. Sokhi, Srinivasa R. G. Vasa, Mariana D. Dabeva, David A. Shafritz, Andrew Kerr
Cell transplantation into hepatic sinusoids, which is necessary for liver repopulation, could cause hepatic ischemia. To examine the effects of cell transplantation on host hepatocytes, we transplanted Fisher 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. Within 24 h of cell transplantation, areas of ischemic necrosis, along with transient disruption of gap junc...... hiện toàn bộ
Transplanted reporter cells help in defining onset of hepatocyte proliferation during the life of F344 rats
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 279 Số 3 - Trang G631-G640 - 2000
Rana P. Sokhi, Pankaj Rajvanshi, Sanjeev Gupta
Transplanted hepatocytes integrate in the liver parenchyma and exhibit gene expression patterns that are similar to adjacent host hepatocytes. To determine the fate of genetically marked hepatocytes in the context of hepatocellular proliferation throughout the rodent life span, we transplanted Fischer 344 (F344) rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. The pr...... hiện toàn bộ
HumanClostridium difficileinfection: altered mucus production and composition
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 308 Số 6 - Trang G510-G524 - 2015
Melinda A. Engevik, Mary Beth Yacyshyn, Kristen A. Engevik, Jiang Wang, Benjamin J. Darien, Daniel J. Hassett, Bruce Yacyshyn, Roger T. Worrell
The majority of antibiotic-induced diarrhea is caused by Clostridium difficile ( C. difficile). Hospitalizations for C. difficile infection (CDI) have tripled in the last decade, emphasizing the need to better understand how the organism colonizes the intestine and maintain infection. The mucus provides an interface for bacterial-host interactions and changes in intestinal mucus have been ...... hiện toàn bộ
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 299 Số 1 - Trang G236-G243 - 2010
Sophie C. Cazanave, Nafisa A. Elmi, Yuko Akazawa, Steven F. Bronk, Justin L. Mott, Gregory J. Gores
Endoplasmic reticulum (ER) stress-mediated apoptosis is a key feature of hepatocyte cytotoxicity by saturated free fatty acids (FFA). This lipoapoptosis is dependent, in part, on the transcriptional upregulation of the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). Although the activator protein (AP)-1 complex facilitates PUMA expression by saturated FFA, the transcription...... hiện toàn bộ
Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 293 Số 1 - Trang G308-G318 - 2007
Parimal Sheth, Noel Delos Santos, Ankur Seth, Nicholas F. LaRusso, R. K. Rao
Bile duct epithelium forms a barrier to the backflow of bile into the liver parenchyma. However, the structure and regulation of the tight junctions in bile duct epithelium is not well understood. In the present study, we evaluated the effect of lipopolysaccharide on tight junction integrity and barrier function in normal rat cholangiocyte monolayers. Lipopolysaccharide disrupts barrier fu...... hiện toàn bộ
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 290 Số 2 - Trang G222-G231 - 2006
Mark W. Musch, Margaret M. Walsh-Reitz, Eugene B. Chang
Oxidants such as monochloramine (NH2Cl) decrease epithelial barrier function by disrupting perijunctional actin and possibly affecting the distribution of tight junctional proteins. These effects can, in theory, disturb cell polarization and affect critical membrane proteins by compromising molecular fence function of the tight junctions. To examine these possibilities...... hiện toàn bộ
Tổng số: 108   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10