American Journal of Physiology - Gastrointestinal and Liver Physiology

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Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 303 Số 10 - Trang G1087-G1095 - 2012
Jamie L. McClellan, J. Mark Davis, Jennifer L. Steiner, Reilly T. Enos, Soo Yeon Jung, James A. Carson, Maria Marjorette O. Peña, Kevin Carnevale, Franklin G. Berger, E. Angela Murphy
Tumor-associated macrophages are associated with poor prognosis in certain cancers. Monocyte chemoattractant protein 1 (MCP-1) is thought to be the most important chemokine for recruitment of macrophages to the tumor microenvironment. However, its role on tumorigenesis in a genetic mouse model of colon cancer has not been explored. We examined the role of MCP-1 on tumor-associated macroph...... hiện toàn bộ
Regulation of gastric epithelial cell development revealed in H+/K+-ATPase β-subunit- and gastrin-deficient mice
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 281 Số 6 - Trang G1502-G1511 - 2001
Teo V. Franic, Louise M. Judd, David Robinson, Simon P. Barrett, Katrina L. Scarff, Paul A. Gleeson, Linda C. Samuelson, Ian R. van Driel
The gastric H+/K+-ATPase is essential for normal development of parietal cells. Here we have directly assessed the role of the H+/K+-ATPase β-subunit (H/K-β) on epithelial cell development by detailed quantitation of the epithelial cell types of the gastric mucosa of H/K-β-deficient mice. H/K-β-deficient mi...... hiện toàn bộ
Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 288 Số 2 - Trang G396-G402 - 2005
Edwina Baskin-Bey, Ali Canbay, Steven F. Bronk, Nathan W. Werneburg, Maria Eugenia Guicciardi, Scott L. Nyberg, Greg J. Barritt
Hepatic steatosis predisposes the liver to cold ischemia-warm reperfusion (CI/WR) injury by unclear mechanisms. Because hepatic steatosis has recently been associated with a lysosomal pathway of apoptosis, our aim was to determine whether this cell-death pathway contributes to CI/WR injury of steatotic livers. Wild-type and cathepsin B-knockout ( Ctsb −/−) mice were f...... hiện toàn bộ
The role of luminal factors in the recovery of gastric function and behavioral changes after chronicHelicobacter pyloriinfection
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 295 Số 4 - Trang G664-G670 - 2008
Elena F. Verdú, Přemysl Berčík, Xian Xi Huang, Jun Lü, Nafia Al-Mutawaly, Hiromi Sakai, Thomas A. Tompkins, Kenneth Croitoru, Eihun Tsuchida, Mary H. Perdue, Stephen M. Collins
The role of chronic infections, such as Helicobacter pylori ( Hp), to produce sustained changes in host physiology remains controversial. In this study, we investigate whether the antigenic or bacterial content of the gut, after Hp eradication, influences the changes in gut function induced by chronic Hp infection. Mice were infected with Hp for 4 mo and then treated with antibiotics or pl...... hiện toàn bộ
A novel ultrasound technique to study the biomechanics of the human esophagus in vivo
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 282 Số 5 - Trang G785-G793 - 2002
Tomoshiro Takeda, Ghassan S. Kassab, Jianmin Liu, James L. Puckett, Rishi R. Mittal, Ravinder K. Mittal
The objectives of this study were to validate a novel ultrasound technique and to use it to study the circumferential stress-strain properties of the human esophagus in vivo. A manometric catheter equipped with a high-compliance bag and a high-frequency intraluminal ultrasonography probe was used to record esophageal pressure and images. Validation studies were performed in vitro followed...... hiện toàn bộ
Measuring esophageal distension by high-frequency intraluminal ultrasound probe
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 283 Số 4 - Trang G886-G892 - 2002
Poong‐Lyul Rhee, Jianmin Liu, James L. Puckett, Ravinder K. Mittal
Distension of the esophagus can cause heartburn and chest pain; however, none of the available techniques to study the esophagus measure esophageal distension. We evaluated the technique of high-frequency intraluminal ultrasound probe (HFIUS) to measure the esophageal cross-sectional area (CSA) during gastroesophageal reflux (GER). The following methods were used: 1) the CSA of agarose ge...... hiện toàn bộ
Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 309 Số 10 - Trang G841-G854 - 2015
Stephen D. Zucker, Megan Vogel, Tammy L. Kindel, David S. Askew, Gila Idelman, Uri Avissar, Ganesh V. Kakarlapudi, Michelle E. Masnovi
Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS). As VCAM-1 and iNOS are important mediators of tissue injury in the dextran sodium sulfate (DSS) murine model of inflammatory colitis, we examined whether bilirubin prevents...... hiện toàn bộ
Establishment of conditionally immortalized epithelial cell lines from the intestinal tissue of adult normal and transgenic mice
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 296 Số 3 - Trang G455-G460 - 2009
Robert H. Whitehead, Pamela S. Robinson
It has proved to be impossible to culture epithelial cells from the gastrointestinal tract of adult animals. Researchers have had to use either cell lines derived from newborn rat small intestine or colon carcinoma cell lines that have retained some of the properties of the gastrointestinal mucosa. We have described a method for establishing conditionally immortalized cell lines from the ...... hiện toàn bộ
Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 305 Số 3 - Trang G225-G240 - 2013
Kshipra Singh, Lori A. Coburn, Daniel P. Barry, Mohammad Asim, Brooks Scull, Margaret M. Allaman, Nuruddeen D. Lewis, M. Kay Washington, Michael J. Rosen, Christopher S. Williams, Rupesh Chaturvedi, Keith T. Wilson
l-Arginine (l-Arg) is a semiessential amino acid that has altered availability in human ulcerative colitis (UC), a form of inflammatory bowel disease, and is beneficial in murine colitis induced by dextran sulfate sodium (DSS), a model with similarity to UC. We assessed the role of cationic amino acid transporter 2 (CAT2), the inducible transporter of l-Arg, in DSS colitis. Expression of C...... hiện toàn bộ
Ca2+sparks and BK currents in gallbladder myocytes: role in CCK-induced response
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 282 Số 1 - Trang G165-G174 - 2002
Marı́a J. Pozo, Guillermo J. Pérez, Mark T. Nelson, Gary M. Mawe
We sought to elucidate the regulation of gallbladder smooth muscle (GBSM) excitability by localized Ca2+release events (sparks) and large-conductance Ca2+-dependent (BK) channels by determining whether sparks exist in GBSM and, if so, whether they activate BK channels. Sparks were identified in isolated GBSM loaded with fluo 4. Each spark was assoc...... hiện toàn bộ
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