American Journal of Physiology - Gastrointestinal and Liver Physiology

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Regulation of gastric epithelial cell development revealed in H+/K+-ATPase β-subunit- and gastrin-deficient mice
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 281 Số 6 - Trang G1502-G1511 - 2001
Teo V. Franic, Louise M. Judd, David Robinson, Simon P. Barrett, Katrina L. Scarff, Paul A. Gleeson, Linda C. Samuelson, Ian R. van Driel
The gastric H+/K+-ATPase is essential for normal development of parietal cells. Here we have directly assessed the role of the H+/K+-ATPase β-subunit (H/K-β) on epithelial cell development by detailed quantitation of the epithelial cell types of the gastric mucosa of H/K-β-deficient mice. H/K-β-deficient mi...... hiện toàn bộ
The role of luminal factors in the recovery of gastric function and behavioral changes after chronicHelicobacter pyloriinfection
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 295 Số 4 - Trang G664-G670 - 2008
Elena F. Verdú, Přemysl Berčík, Xian Xi Huang, Jun Lü, Nafia Al-Mutawaly, Hiromi Sakai, Thomas A. Tompkins, Kenneth Croitoru, Eihun Tsuchida, Mary H. Perdue, Stephen M. Collins
The role of chronic infections, such as Helicobacter pylori ( Hp), to produce sustained changes in host physiology remains controversial. In this study, we investigate whether the antigenic or bacterial content of the gut, after Hp eradication, influences the changes in gut function induced by chronic Hp infection. Mice were infected with Hp for 4 mo and then treated with antibiotics or pl...... hiện toàn bộ
A novel ultrasound technique to study the biomechanics of the human esophagus in vivo
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 282 Số 5 - Trang G785-G793 - 2002
Tomoshiro Takeda, Ghassan S. Kassab, Jianmin Liu, James L. Puckett, Rishi R. Mittal, Ravinder K. Mittal
The objectives of this study were to validate a novel ultrasound technique and to use it to study the circumferential stress-strain properties of the human esophagus in vivo. A manometric catheter equipped with a high-compliance bag and a high-frequency intraluminal ultrasonography probe was used to record esophageal pressure and images. Validation studies were performed in vitro followed...... hiện toàn bộ
Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 279 Số 4 - Trang G815-G826 - 2000
Sanjeev Gupta, Pankaj Rajvanshi, Harmeet Malhi, Sanjeev Slehria, Rana P. Sokhi, Srinivasa R. G. Vasa, Mariana D. Dabeva, David A. Shafritz, Andrew Kerr
Cell transplantation into hepatic sinusoids, which is necessary for liver repopulation, could cause hepatic ischemia. To examine the effects of cell transplantation on host hepatocytes, we transplanted Fisher 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. Within 24 h of cell transplantation, areas of ischemic necrosis, along with transient disruption of gap junc...... hiện toàn bộ
Transplanted reporter cells help in defining onset of hepatocyte proliferation during the life of F344 rats
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 279 Số 3 - Trang G631-G640 - 2000
Rana P. Sokhi, Pankaj Rajvanshi, Sanjeev Gupta
Transplanted hepatocytes integrate in the liver parenchyma and exhibit gene expression patterns that are similar to adjacent host hepatocytes. To determine the fate of genetically marked hepatocytes in the context of hepatocellular proliferation throughout the rodent life span, we transplanted Fischer 344 (F344) rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. The pr...... hiện toàn bộ
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 299 Số 1 - Trang G236-G243 - 2010
Sophie C. Cazanave, Nafisa A. Elmi, Yuko Akazawa, Steven F. Bronk, Justin L. Mott, Gregory J. Gores
Endoplasmic reticulum (ER) stress-mediated apoptosis is a key feature of hepatocyte cytotoxicity by saturated free fatty acids (FFA). This lipoapoptosis is dependent, in part, on the transcriptional upregulation of the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). Although the activator protein (AP)-1 complex facilitates PUMA expression by saturated FFA, the transcription...... hiện toàn bộ
Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 293 Số 1 - Trang G308-G318 - 2007
Parimal Sheth, Noel Delos Santos, Ankur Seth, Nicholas F. LaRusso, R. K. Rao
Bile duct epithelium forms a barrier to the backflow of bile into the liver parenchyma. However, the structure and regulation of the tight junctions in bile duct epithelium is not well understood. In the present study, we evaluated the effect of lipopolysaccharide on tight junction integrity and barrier function in normal rat cholangiocyte monolayers. Lipopolysaccharide disrupts barrier fu...... hiện toàn bộ
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 290 Số 2 - Trang G222-G231 - 2006
Mark W. Musch, Margaret M. Walsh-Reitz, Eugene B. Chang
Oxidants such as monochloramine (NH2Cl) decrease epithelial barrier function by disrupting perijunctional actin and possibly affecting the distribution of tight junctional proteins. These effects can, in theory, disturb cell polarization and affect critical membrane proteins by compromising molecular fence function of the tight junctions. To examine these possibilities...... hiện toàn bộ
Glucocerebroside treatment ameliorates ConA hepatitis by inhibition of NKT lymphocytes
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 289 Số 5 - Trang G917-G925 - 2005
Maya Margalit, Samir Abu Gazala, Shwaqi J. Ghazala, Ruslana Alper, Eran Elinav, Andreas Klein, Victoria Doviner, Yoav Sherman, Barbara Thalenfeld, Dean Engelhardt, Elazar Rabbani, Yaron Ilan
Concanavalin A (ConA) induces natural killer T (NKT) cell-mediated liver damage. Glucocerebroside (GC) is a naturally occurring glycolipid. Our aims were to determine the effect of GC in a murine model of ConA-induced hepatitis. Mice in groups A and B were treated with GC 2 h before and 2 h following administration of ConA, respectively; group C mice were treated with ConA; group D mice wa...... hiện toàn bộ
III. Senescent enteric nervous system: lessons from extraintestinal sites and nonmammalian species
American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 283 Số 5 - Trang G1020-G1026 - 2002
John Wiley
Functional changes in GI motility associated with advanced age include slowing of gastric emptying, decreased peristalsis, and slowing of colonic transit. These changes appear to be associated with region-specific loss of neurons and impaired function. The mechanism(s) underlying physiological aging are likely to be multifactorial. Alterations in specific signal transduction pathways have...... hiện toàn bộ
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