American Journal of Physiology - Gastrointestinal and Liver Physiology
SCIE-ISI SCOPUS (1980-2023)
0193-1857
1522-1547
Mỹ
Cơ quản chủ quản: AMER PHYSIOLOGICAL SOC , American Physiological Society
Lĩnh vực:
Physiology (medical)HepatologyGastroenterologyPhysiology
Các bài báo tiêu biểu
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammationPatients with ulcerative colitis and Crohn's disease are at increased risk for developing colorectal cancer. To date, no known genetic basis has been identified to explain colorectal cancer predisposition in these inflammatory bowel diseases. Instead, it is assumed that chronic inflammation is what causes cancer. This is supported by the fact that colon cancer risk increases with longer du... ... hiện toàn bộ
Tập 287 Số 1 - Trang G7-G17 - 2004
The adherent gastrointestinal mucus gel layer: thickness and physical state in vivoDivergent results from in vitro studies on the thickness and appearance of the gastrointestinal mucus layer have previously been reported. With an in vivo model, we studied mucus gel thickness over time from stomach to colon. The gastrointestinal tissues of Inactin-anesthetized rats were mounted luminal side up for intravital microscopy. Mucus thickness was measured with a micropipette bef... ... hiện toàn bộ
Tập 280 Số 5 - Trang G922-G929 - 2001
IL-22 is increased in active Crohn’s disease and promotes proinflammatory gene expression and intestinal epithelial cell migrationIL-22 is produced by activated T cells and signals through a receptor complex consisting of IL-22R1 and IL-10R2. The aim of this study was to analyze IL-22 receptor expression, signal transduction, and specific biological functions of this cytokine system in intestinal epithelial cells (IEC). Expression studies were performed by RT-PCR. Signal transduction was analyzed by Western blot expe... ... hiện toàn bộ
Tập 290 Số 4 - Trang G827-G838 - 2006
Secreted bioactive factors fromBifidobacterium infantisenhance epithelial cell barrier functionLive probiotic bacteria are effective in reducing gut permeability and inflammation. We have previously shown that probiotics release peptide bioactive factors that modulate epithelial resistance in vitro. The objectives of this study were to determine the impact of factors released from Bifidobacteria infantis on intestinal epithelial cell permeability and tight junction proteins and to a... ... hiện toàn bộ
Tập 295 Số 5 - Trang G1025-G1034 - 2008
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis Inflammatory bowel disease (IBD) arises from a dysregulated mucosal immune response to luminal bacteria. Toll-like receptor (TLR)4 recognizes LPS and transduces a proinflammatory signal through the adapter molecule myeloid differentiation marker 88 (MyD88). We hypothesized that TLR4 participates in the innate immune response to luminal bacteria and the development of colitis. TLR4−/− and ... ... hiện toàn bộ
Tập 288 Số 5 - Trang G1055-G1065 - 2005
Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in ratThis study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long-Evans dams and their male pups were reared under two conditions: 1) 180 min daily maternal separation (MS180) on postnatal days 2–14 or 2) no handling or separation (NH). At 2 mo of age, visceromotor responses to graded intensities of phasic color... ... hiện toàn bộ
Tập 282 Số 2 - Trang G307-G316 - 2002
V. Stress and irritable bowel syndrome Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhan... ... hiện toàn bộ
Tập 280 Số 4 - Trang G519-G524 - 2001
Functional modulation of enterocytes by gram-positive and gram-negative microorganismsClinical studies have suggested that so-called probiotic bacteria may be effective as therapy in inflammatory bowel disease. However, the molecular mechanisms of their interaction with the intestinal surface remain undefined. The influence of whole probiotic bacteria [ Escherichia coli Nissle 1917 (EcN); probiotic mixture VSL#3 (PM)], bacterial cell lysates, and conditioned media on transe... ... hiện toàn bộ
Tập 286 Số 4 - Trang G613-G626 - 2004
Inflammatory bowel disease is associated with changes of enterocytic junctionsChanges of the intestinal mucosal barrier are considered to play a role in the pathogenesis of inflammatory bowel disease (IBD). Our experiments were designed to identify dysregulation of epithelial junctional molecules in the IBD intestinum and to address whether altered expression of these molecules is a primary event in IBD or a phenomenon secondary to the inflammatory process. Noninfla... ... hiện toàn bộ
Tập 281 Số 1 - Trang G216-G228 - 2001
Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tractPopulations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), a protein that is also expressed on mast cells. No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca2+ -activated ... ... hiện toàn bộ
Tập 296 Số 6 - Trang G1370-G1381 - 2009