American Journal of Physiology - Cell Physiology
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Turnover of adenosine in plasma of human and dog blood To determine half-life and turnover of plasma adenosine, heparinized blood from healthy volunteers was incubated with radiolabeled adenosine in the physiological concentration range of 0.1-1 microM. Plasma levels of adenosine in vitro were 82 +/- 14 nM and were similar to those determined immediately after blood collection with a "stopping solution." Dipyridamole (83 microM) and erythro-9... ...
American Journal of Physiology - Cell Physiology - Tập 256 Số 4 - Trang C799-C806 - 1989
Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2 We have previously reported that glucosamine protected neonatal rat ventricular myocytes against ischemia-reperfusion (I/R) injury, and this was associated with an increase in protein O-linked- N-acetylglucosamine ( O-GlcNAc) levels. However, the protective effect of glucosamine could be mediated via pathways other that O-GlcNAc formation; thus the initial goal of the present study was to... ...
American Journal of Physiology - Cell Physiology - Tập 294 Số 6 - Trang C1509-C1520 - 2008
Expression of glucocorticoid receptor α- and β-isoforms in human cells and tissues Alternative splicing of the human glucocorticoid receptor (GR) primary transcript generates two protein isoforms: GR-α and GR-β. We investigated the expression of both GR isoforms in healthy human cells and tissues. GR-α mRNA abundance (×106 cDNA copies/μg total RNA) was as follows: brain (3.83 ± 0.80) > skeletal muscle > macrophages > lung > kidney > l... ...
American Journal of Physiology - Cell Physiology - Tập 283 Số 4 - Trang C1324-C1331 - 2002
IFN-γ + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38 mapk in a mouse macrophage cell line Nitric oxide (NO·) produced by inducible nitric oxide synthase (iNOS) mediates a number of important physiological and pathophysiological processes. The objective of this investigation was to examine the role of mitogen-activated protein kinases (MAPKs) in the regulation of iNOS and NO· by interferon-γ (IFN-γ) + lipopolysaccharide (LPS) in macrophages using specific inhibitors and dominan... ...
American Journal of Physiology - Cell Physiology - Tập 280 Số 3 - Trang C441-C450 - 2001
Plasticity and stressor specificity of osmotic and heat shock responses of Gillichthys mirabilis gill cells Short-term effects of osmotic and heat shock on proteins of Gillichthys mirabilis gill cells were analyzed. The protein synthesis rate (PSR) of gill cells was influenced by hyperosmotic shock (335-->635 mosmol/kgH2O) and heat shock (25-->37 degrees C), but not by hyposmotic shock (335-->190 mosmol/kgH2O). Between 4 and 6 h after hyperosmotic shock, gill cell protein synthesis was... ...
American Journal of Physiology - Cell Physiology - Tập 271 Số 4 - Trang C1181-C1193 - 1996
Intracellular Ca regulation during secretagogue stimulation of the parietal cell Intracellular [Ca] ([Ca]i) was measured following secretagogue stimulation of rabbit gastric glands loaded with the Ca-sensitive dye fura-2. Glands were mounted on cover slips and placed either in a perfused cuvette (for spectrofluorimetric measurements on whole glands) or in a chamber on the stage of a microscope (for microspectrofluorimetric measurements on single parietal cells within ... ...
American Journal of Physiology - Cell Physiology - Tập 254 Số 1 - Trang C130-C140 - 1988
Temperature acclimation: effects on membrane physiology of an identified snail neuron The neuronal basis for thermal acclimation was examined by comparing the short- and long-term effects of temperature change on the physiological properties of an identified neuron in the isolated ganglion of Hexis aspersa. Using intracellular electrophysiological techniques, we found that the frequency of spontaneous action potentials and excitability of neurons from warm-acclimated anima... ...
American Journal of Physiology - Cell Physiology - Tập 239 Số 3 - Trang C47-C57 - 1980
Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers Mutations in the central domain of the skeletal muscle ryanodine receptor (RyR) cause malignant hyperthermia (MH). A synthetic peptide (DP4) in this domain (Leu-2442–Pro-2477) produces enhanced ryanodine binding and sensitized Ca2+ release in isolated sarcoplasmic reticulum, similar to the properties in MH, possibly because the peptide disrupts the normal interdomain ... ...
American Journal of Physiology - Cell Physiology - Tập 281 Số 1 - Trang C207-C214 - 2001
Voltage dependence of Ca2+sparks in intact cerebral arteries Ca2+ sparks have been previously described in isolated smooth muscle cells. Here we present the first measurements of local Ca2+ transients (“Ca2+ sparks”) in an intact smooth muscle preparation. Ca2+ sparks appear to result from the opening of ryanodine-sensitive Ca2+ release (RyR) cha... ...
American Journal of Physiology - Cell Physiology - Tập 274 Số 6 - Trang C1755-C1761 - 1998
Two-step Ca2+ intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes The relative contributions of Ca2+ -induced Ca2+ release (CICR) versus Ca2+ influx through voltage-dependent Ca2+ channels (VDCCs) to excitation-contraction coupling has not been defined in most smooth muscle cells (SMCs). The present study was undertaken to address this issue in mouse urinary bladder (UB) ... ...
American Journal of Physiology - Cell Physiology - Tập 290 Số 2 - Trang C388-C403 - 2006
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