American Journal of Hematology
SCIE-ISI SCOPUS (1976-2025)
0361-8609
1096-8652
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
Hematology
Các bài báo tiêu biểu
Hematological findings and complications of COVID ‐19
Tập 95 Số 7 - Trang 834-847 - 2020
AbstractCOVID‐19 is a systemic infection with a significant impact on the
hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal
laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and
peak platelet/lymphocyte ratio may also have prognostic value in determining
severe cases. During the disease course, longitudinal evaluation of lymphocyte
count dyna...
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer
Tập 94 Số S1 - 2019
Chimeric antigen receptor (CAR) T‐cell therapy represents a major advancement in
personalized cancer treatment. In this strategy, a patient's own T cells are
genetically engineered to express a synthetic receptor that binds a tumor
antigen. CAR T cells are then expanded for clinical use and infused back into
the patient's body to attack and destroy chemotherapy‐resistant cancer. Dramatic
clinical ...
Treatment of sinus histiocytosis with massive lymphadenopathy (rosai‐dorfman disease): Report of a case and literature review
Tập 69 Số 1 - Trang 67-71 - 2002
AbstractSinus histiocytosis with massive lymphadenopathy (SHML) is a rare
disorder of unknown etiology, usually associated with lymph node enlargement in
various superficial or deep sites. It usually shows a prolonged clinical course
with occasional exacerbation and remission phases. We describe the long‐term
follow‐up of a case of SHML that showed typical clinical features and in which
various th...
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
Tập 87 Số S1 - 2012
AbstractThe new oral anticoagulants dabigatran, rivaroxaban and apixaban have
advantages over warfarin which include no need for laboratory monitoring, less
drug–drug interactions and less food‐drug interactions. However, there is no
established antidote for patients who are bleeding or require emergent surgery
and there is a paucity of evidence to guide the clinical care during these
situations. ...
Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions
Tập 84 Số 9 - Trang 618-625 - 2009
Estimated annual numbers of US acute‐care hospital patients at risk for venous thromboembolism
Tập 82 Số 9 - Trang 777-782 - 2007
AbstractVenous thromboembolism (VTE) is a major US health problem. However, the
total number of US inpatients who are at risk for VTE is unknown. Our objective
was to estimate the number of US acute‐care hospital inpatients who were at risk
for VTE according to criteria established by the Seventh American College of
Chest Physicians (ACCP) Consensus Conference on Antithrombotic and Thrombolytic
Th...
Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML
Tập 90 Số 8 - Trang 732-736 - 2015
The pathophysiology of IDH mutations in tumorigenesis is increasingly described,
yet the prognostic significance of IDH1 and IDH2 mutations in AML remains
controversial. The primary objective of this study was to define the natural
history and prognosis of patients with AML and IDH1 or IDH2 mutations and
provide historical survival expectations. A total of 826 patients treated from
2010 to 2014 at...
Cryopreservation of hematopoietic stem cells
Tập 82 Số 6 - Trang 463-472 - 2007
AbstractStem cell transplantation represents a critical approach for the
treatment of many malignant and non‐malignant diseases. The foundation for these
approaches is the ability to cryopreserve marrow cells for future use. This
technique is routinely employed in all autologous settings and is critical for
cord blood transplantation. A variety of cryopreservatives have been used with
multiple fre...
Primary myelofibrosis: 2021 update on diagnosis, risk‐stratification and management
Tập 96 Số 1 - Trang 145-162 - 2021
AbstractDisease OverviewPrimary myelofibrosis (PMF) is a myeloproliferative
neoplasm (MPN) characterized by stem cell‐derived clonal myeloproliferation that
is often but not always accompanied by JAK2, CALR, or MPL mutations. Additional
disease features include bone marrow reticulin/collagen fibrosis, aberrant
inflammatory cytokine expression, anemia, hepatosplenomegaly, extramedullary
hematopoies...
Increasing mortality from thrombotic thrombocytopenic purpura in the United States—analysis of national mortality data, 1968–1991
Tập 50 Số 2 - Trang 84-90 - 1995
AbstractThrombotic thrombocytopenic purpura (TTP) is a rare disease and the
epidemiologic features have been incompletely characterized. Because of the
historically high case‐fatality rate for TTP, we analyzed U.S. multiple
cause‐of‐death mortality data with TTP listed on the death record for the period
1968–1991, in order to estimate the incidence of TTP, to characterize
demographic features of t...