American Journal of Hematology
0361-8609
1096-8652
Mỹ
Cơ quản chủ quản: Wiley-Liss Inc. , WILEY
Lĩnh vực:
Hematology
Phân tích ảnh hưởng
Thông tin về tạp chí
The American Journal of Hematology provides broad coverage of experimental and clinical features of blood diseases in humans and in animal models of human disease. The journal publishes original contributions in non-malignant and malignant hematological diseases including clinical and basic studies in hemostasis and thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports describing novel therapeutic approaches to diagnosis and treatment of hematological diseases are welcomed and encouraged. The journal includes regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, letters and correspondence.
Các bài báo tiêu biểu
Successful treatment of a patient with HIV‐associated multicentric Castleman disease (MCD) with thalidomide
Tập 75 Số 3 - Trang 176-177 - 2004
Treatment of sinus histiocytosis with massive lymphadenopathy (rosai‐dorfman disease): Report of a case and literature review Abstract Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder of unknown etiology, usually associated with lymph node enlargement in various superficial or deep sites. It usually shows a prolonged clinical course with occasional exacerbation and remission phases. We describe the long‐term follow‐up of a case of SHML that showed typical clinical features and in which various therapeutic strategies were attempted. Chemotherapy and α‐interferon (IFN) were ineffective; surgery was ultimately required with satisfactory results. From an extensive literature review we found different treatment strategies in SHML in the 80 cases published between 1969 and 2000. Spontaneous resolution of adenopathies is frequently observed: 32 out of 40 cases which did not receive chemotherapy, radiotherapy, or surgery were healthy at the time of publication. Radiotherapy alone showed conflicting results: 3 complete remissions (CR) were obtained in the 9 patients treated. Surgical debulking when required was effective—8/9 CR—while chemotherapy showed generally negative results. IFN has been previously employed in only one case. In conclusion, clinical observation without treatment is advisable when possible. In the presence of vital organ compression and/or extranodal localization with important clinical signs, surgical debulking may be necessary. Radiotherapy has shown limited efficacy, while chemotherapy is in general ineffective. More experience is needed to evaluate the role of IFN. Am. J. Hematol. 69:67‐71, 2002. © 2002 Wiley‐Liss, Inc.
Tập 69 Số 1 - Trang 67-71 - 2002
Recombinant FVIIa in the treatment of bleeding in acquired hemophilia
Tập 70 Số 4 - Trang 333-333 - 2002
Progressive multifocal leukoencephalopathy after fludarabine therapy for low‐grade lymphoproliferative disease Abstract Fludarabine is becoming the initial therapy for low‐grade lymphoproliferative malignancies, such as CLL and follicular lymphoma. Fludarabine is highly immunosuppressive in addition to being myelosuppressive and has been associated with neurotoxicity. Progressive multifocal leukoencephalopathy (PML) is an infection with JC virus of the white matter of the central nervous system seen mostly in immunosuppressed patients. We describe two patients treated with fludarabine who developed PML. Immunolabeling was positive for JCV in both patients, but PCR was repeatedly negative in one of them. We suggest that fludarabine may increase the risk of PML in patients with lymphoproliferative diseases. Am. J. Hematol. 70:51–54, 2002. © 2002 Wiley‐Liss, Inc.
Tập 70 Số 1 - Trang 51-54 - 2002
Venous thromboembolism prophylaxis in medically ill patients and the development of strategies to improve prophylaxis rates
Tập 78 Số 3 - Trang 167-172 - 2005
Simultaneous lupus anticoagulant and anticardiolipin assays and clinical detection of antiphospholipids Abstract Lupus anticoagulants and/or anticardiolipin antibodies were detected in 100 patients with autoimmune disorders, thrombosis, or pregnancy loss. Significant agreement between tests for these two antipnospholipid activities was lacking. Performing both assays is thus important in maximizing the likelihood of detecting antiphospnolipids that may have clinical relevance.
Tập 32 Số 2 - Trang 148-149 - 1989
Heparin‐induced thrombocytopenia: Association with a platelet aggregating factor and arterial thromboses Abstract Eleven patients with heparin‐induced thrombocytopenia were studied. Thrombocytopenia appeared 3–16 days following the initiation of prophylactic or therapeutic doses of heparin. The mean lowest platelet count recorded was 48,000/mm3 . When heparin was stopped, recovery from thrombocytopenia began within 24 hours and was complete by ten days. Two patients developed fatal thromboses, and two others had myocardial infarctions while thrombocytopenic. In the serum of seven patients, including three of the four with arterial thrombosis, a heparin‐dependent platelet aggregating factor was present. The factor caused release of platelet 14 C serotonin but did not lyse platelets. It was present in the globulin fraction of all positive sera, and in one serum studied it was isolated in the IgG/IgA immunoglobulin fraction. The factor was not present in 16 normal sera or in the sera of 15 nonthrombocytopenic patients receiving heparin. Our observations suggest that heparin‐induced thrombocytopenia is common and that, in some patients it may be accompanied by severe arterial thrombosis. In vivo platelet aggregation is a possible explanation for the thrombocytopenia and the thrombosis in this disorder.
Tập 6 Số 2 - Trang 125-133 - 1979
The direct antiglobulin test: A critical step in the evaluation of hemolysis Abstract The direct antiglobulin test (DAT) is a laboratory test that detects immunoglobulin and/or complement on the surface of red blood cells. The utility of the DAT is to sort hemolysis into an immune or nonimmune etiology. As with all tests, DAT results must be viewed in light of clinical and other laboratory data. This review highlights the most common clinical situations where the DAT can help classify causes of hemolysis, including autoimmune hemolytic anemia, transfusion‐related hemolysis, hemolytic disease of the fetus/newborn, drug‐induced hemolytic anemia, passenger lymphocyte syndrome, and DAT‐negative hemolytic anemia. In addition, the pitfalls and limitations of the test are addressed. False reactions may occur with improper technique, including improper washing, centrifugation, and specimen agitation at the time of result interpretation. Patient factors, such as spontaneous red blood cell agglutination, may also contribute to false results. Am. J. Hematol. 87:707–709, 2012. © 2012 Wiley Periodicals, Inc.
Tập 87 Số 7 - Trang 707-709 - 2012
Factor VII deficiency Abstract This report describes three patients with factor (F) VII deficiency: two adult siblings and an unrelated 5½‐month‐old child who succumbed after several central nervous system (CNS) hemorrhages. This event prompted a review of the literature concerning the incidence and characteristics of intracranial hemorrhage in congenital F VII deficiency. Of 138 patients reported to have F VII deficiency, only 75 were considered to have a true deficiency. There was a 1:1 sex distribution with a 19% incidence of consanguinity in the 63 families which these 75 patients represented. CNS hemorrhage occurred in 12 of the 75 proven factor‐deficient patients – an incidence of 16.0%. There was a 1.4:1 female predominance in this group, with a 44.4% incidence of consanguinity in their nine families. Except for one patient with hypertension, there was no history of preceding trauma or previous underlying CNS abnormality, though head trauma with a difficult vaginal delivery may have occurred in five infants. Diagnostic lumbar puncture or ventricular tap revealed bloody, xanthochromic cerebrospinal fluid in five. Five patients with F VII deficiency developed a CNS hemorrhage prior to 1 week of age, and none survived. Seven patients older than 1 week of age suffered such an event, and four of these survived. It is concluded that the greatest risk factor for development of CNS hemorrhage is trauma related to the birth process.
Tập 10 Số 1 - Trang 79-88 - 1981