Aging Clinical and Experimental Research
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Predictors for institutionalization and prosthetic ambulation after major lower extremity amputation during an eight-year follow-up
Aging Clinical and Experimental Research - Tập 21 - Trang 129-135 - 2013
Background and aims: Major lower extremity amputation (LEA) leads to great loss in mobility, exposing old people to the risk of losing their independent living status. This study applies predictors for institutionalization and considers prosthesis use by major lower leg amputees with peripheral arterial disease (PAD). Methods: 119 PAD patients admitted from home (mean age 73.6, SD......
Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
Aging Clinical and Experimental Research - Tập 31 Số 10 - Trang 1375-1389 - 2019
Survival following vertebral compression fractures in population over 65 years old
Aging Clinical and Experimental Research - Tập 35 - Trang 1609-1617 - 2023
Lower mortality has been demonstrated when vertebral compression fractures (VCFs) are treated surgically (vertebral augmentation) vs. conservatively. To analyze the overall survival in patients over 65 who suffer a VCF, to review the principal causes of death, and to detect which factors are associated with a greater risk of mortality. Patients over 65 years old diagnosed with acute, non-pathologi......
Predicting mild cognitive impairment progression to Alzheimer’s disease based on machine learning analysis of cortical morphological features
Aging Clinical and Experimental Research - Tập 35 - Trang 1721-1730 - 2023
To establish a model for predicting mild cognitive impairment (MCI) progression to Alzheimer's disease (AD) using morphological features extracted from a joint analysis of voxel-based morphometry (VBM) and surface-based morphometry (SBM).
We analyzed data from 121 MCI patients from the Alzheimer's Disease Neuroimaging Initiative, 32 of whom progressed to AD during a 4-year follow-up period and we......
Functional autonomy and 12-month mortality in older adults with proximal femoral fractures in an orthogeriatric setting: risk factors and gender differences
Aging Clinical and Experimental Research - Tập 35 - Trang 1063-1071 - 2023
Proximal femur fractures have a negative impact on loss of functional autonomy and mortality. The aim of this retrospective study was to evaluate functional autonomy and mortality in a group of older adults with hip fractures managed in an orthogeriatric setting 12 months after discharge and to determine if gender affected outcome. In all participants, we assessed clinical history, functional pre-......
Readmissions to a geriatric medical unit: Is prevention possible?
Aging Clinical and Experimental Research - Tập 4 - Trang 61-67 - 2013
Of the 622 patients admitted to a geriatric medical unit during the period November 1985 to October 1986, 211 (33.9%) had been discharged from hospital within the previous year. Of these, 117 (55.5%) had previously been admitted to the geriatric medical unit (18.8% of all admissions). The reasons for read-mission were deterioration of existing disease (47.4%), new medical events (33.2%), poor mana......
Hospital admissions and mortality over 20 years in community-dwelling older people: findings from the Hertfordshire Cohort Study
Aging Clinical and Experimental Research - Tập 35 - Trang 2751-2757 - 2023
Demographic changes worldwide are leading to pressures on health services, with hospital admissions representing an important contributor. Here, we report admission types experienced by older people and examine baseline risk factors for subsequent admission/death, from the community-based Hertfordshire Cohort Study. 2997 participants (1418 women) completed a baseline questionnaire and clinic visit......
Combined measurement of serum albumin and high-density lipoprotein cholesterol strongly predicts mortality in frail older nursing-home residents
Aging Clinical and Experimental Research - Tập 16 - Trang 472-475 - 2013
Background and aims: The aim of this study was to verify the hypothesis that a combined measurement of albumin and HDL-C might predict total mortality in institutionalized frail older residents. Methods: Participants were 344 older subjects (272 F, 72 M), living in the “Istituto Riposo Anziani” (I.R.A.), a nursing-home located in Padova, North-east Italy. Functional status, comorb......
Prefrontal cortex activation while walking did not change but gait speed improved after a randomized physical therapy intervention
Aging Clinical and Experimental Research - Tập 36 - Trang 1-10 - 2024
Higher prefrontal cortex (PFC) activation while walking may indicate reduced gait automaticity. We examine whether PFC activation during walking improves after training in older adults at risk for mobility disability. Forty-two adults aged ≥ 65 participated in a randomized clinical trial (NCT026637780) of a 12-week timing and coordination physical therapy intervention to improve walking (n = 20 in......
Probiotics and bone disorders: the role of RANKL/RANK/OPG pathway
Aging Clinical and Experimental Research - Tập 32 - Trang 363-371 - 2019
The skeleton is the framework and in charge of body configuration preservation. As a living tissue, bones are constantly being formed and absorbed. Osteoblasts and osteoclasts are the main bone cells and balance between their activities indicates bone health. Several mechanisms influence the bone turnover and RANKL/RANK/OPG pathway is one of them. This system, whose components are part of the tumo......
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