Agents and Actions
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Human platelet cationic proteins bind to rat glomeruli, induce loss of anionic charges and increase glomerular permeability
Agents and Actions - - 1985
Paul-Peter Tak, Academic Medical Center, University of Amsterdam, The Netherlands (ed): New Therapeutic Targets in Rheumatoid Arthritis. (PIR: Progress in Inflammation Research Series)
Agents and Actions - - 2010
The clinical significance of elevated CSF and plasma histamine in cerebral aneurysm surgery utilizing cardiopulmonary bypass with total circulatory arrest
Agents and Actions - Tập 23 - Trang 343-347 - 1988
Recently there has been a renewed interest in the neurosurgical treatment of large cerebral aneurysms and AV malformations utilising cardiopulmonary bypass (CPB) and total circulatory arrest (TCA). However, the differing tolerance limits of coagulation and bleeding, pH control and fluid constraint are difficult to reconcile. Although clinical assessment, electro encephalogram (EEG) and intracrania......
Intestinal anaphylaxis in the rat: Mediators responsible for the ion transport abnormalities
Agents and Actions - Tập 28 - Trang 185-191 - 1989
Antigen challenge of jejunal epithelium from rats sensitized to egg albumin induces an active Cl− secretory process secondary to release of mucosal mast cell mediators. The present study was designed to define the relative role of these mast cell mediators and the enteric nervous system in the transport abnormalities associated with intestinal anaphylaxis. Net ion transport of stripped jejural tis......
Inhibitory effect of famotidine on cat gastric secretion
Agents and Actions - Tập 19 - Trang 188-193 - 1986
The inhibitory effect of the novel H2 receptor antagonist famotidine was studied in conscious gastric fistula cats against dimaprit-induced hypersecretion, in comparison with ranitidine. On the secretory plateau induced by dimaprit (2 μmol kg−1 h−1) famotidine (0.05–0.2 μmol kg−1 i.v.) exerted a dose-dependent inhibitory effect, being approximately 4.5 times as potent as ranitidine (ID50 values we......
Reactive oxygen species downregulate the expression of pro-inflammatory genes by human chondrocytes
Agents and Actions - Tập 52 Số 3 - Trang 111-118 - 2003
H1-receptor dependent increase in platelet aggregation is mediated by intracellular calcium
Agents and Actions - Tập 36 - Trang C402-C405 - 1992
The influence of histamine on human platelet function was studied by measuring the uptake of [3H]-histamine and by evaluating the effect of histamine on Ca2+ influx and on intracellular Ca2+ levels. The uptake of histamine by platelets is significantly reduced by mepyramine and unaffected by cimetidine. Histamine was found to increase both the [45Ca]2+ uptake by resting and stimulated platelets, a......
FcγRIIa requires lipid rafts, but not co-localization into rafts, for effector function
Agents and Actions - Tập 62 - Trang 37-43 - 2012
To determine if receptor localization into lipid rafts, or the lipid rafts themselves, are important for FcγRIIa effector functions. Wild-type FcγRIIa or mutant FcγRIIa(C208A) that does not translocate to lipid rafts were transfected into Chinese hamster ovary (CHO) cells which have been shown to be reliable cells for studying FcγR function. Cells were treated with buffer or methyl-β-cyclodextrin ......
Azelastine inhibits stimulated histamine release from human lung tissuein vitro but does not alter cyclic nucleotide content
Agents and Actions - Tập 28 - Trang 16-21 - 1989
To investigate the mechanism by which azelastine may be effective therapeutically in asthma, we studied its ability to inhibit anti-IgE- and calcium ionophore A23187-stimulated histamine release from human lung and to alter lung cyclic nucleotide levels. Significant inhibition of histamine release from both anti-IgE- and A23187-stimulated human tissue was aparent after 30 minutes preincubation of ......
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