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H1-receptor dependent increase in platelet aggregation is mediated by intracellular calcium
Agents and Actions - Tập 36 - Trang C402-C405 - 1992
P. F. Mannaioni, A. Pistelli, M. G. Di Bello, F. Gambassi, E. Masini
The influence of histamine on human platelet function was studied by measuring the uptake of [3H]-histamine and by evaluating the effect of histamine on Ca2+ influx and on intracellular Ca2+ levels. The uptake of histamine by platelets is significantly reduced by mepyramine and unaffected by cimetidine. Histamine was found to increase both the [45Ca]2+ uptake by resting and stimulated platelets, a...... hiện toàn bộ
Azelastine inhibits stimulated histamine release from human lung tissuein vitro but does not alter cyclic nucleotide content
Agents and Actions - Tập 28 - Trang 16-21 - 1989
M. M. Little, D. R. Wood, T. B. Casale
To investigate the mechanism by which azelastine may be effective therapeutically in asthma, we studied its ability to inhibit anti-IgE- and calcium ionophore A23187-stimulated histamine release from human lung and to alter lung cyclic nucleotide levels. Significant inhibition of histamine release from both anti-IgE- and A23187-stimulated human tissue was aparent after 30 minutes preincubation of ...... hiện toàn bộ
A comparison of tissue gold levels in guinea-pigs after treatment with Myocrisin injected intramuscularly and triethylphosphine gold chloride and Myocrisin administered orally
Agents and Actions - Tập 8 - Trang 546-550 - 1978
H. Kamel, D. H. Brown, J. M. Ottaway, W. E. Smith, J. Cottney, A. J. Lewis
A comparative study of tissue gold levels produced in guinea-pigs after the oral administration of either triethyl-phosphine gold chloride or Myocrisin (sodium aurothiomalate) or after the injection of Myocrisin intramuscularly is reported. Gold concentrations were determined 5, 24 and 168 hours after administration in stomach, small intestine, large intestine, kidney, liver and spleen and 5 and 2...... hiện toàn bộ
Advances in prostaglandin, thromboxane and leukotriene research volume 16: leukotrienes and prostanoids in health and disease
Agents and Actions - - 1987
Joseph Chang
A new model of acute inflammation: Cobra venom factor induced paw oedema
Agents and Actions - Tập 13 - Trang 437-438 - 1983
S. Leyck, E. Etschenberg, U. Hadding, J. Winkelmann
Dual role of ANGPTL4 in inflammation
Agents and Actions - Tập 72 - Trang 1303-1313 - 2023
Yuyue Zuo, Zhen He, Yu Chen, Lei Dai
Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like protein family and mediates the inhibition of lipoprotein lipase activity. Emerging evidence suggests that ANGPTL4 has pleiotropic functions with anti- and pro-inflammatory properties. A thorough search on PubMed related to ANGPTL4 and inflammation was performed. Genetic inactivation of ANGPTL4 can significantly reduce the risk of deve...... hiện toàn bộ
Inhibition of histamine-N-methyltransferase activity by neuromuscular blocking drugs
Agents and Actions - Tập 17 - Trang 27-31 - 1985
D. G. Harle, B. A. Baldo, M. M. Fisher
On the basis of previous findings that histamine-N-methyltransferase (HMT) activity can be significantly enhanced or inhibited by a number of analogues of histamine and drugs containing dialkylaminoalkyl moieties, we investigated whether the neuromuscular blocking drugs alcuronium,d-tubocurarine, decamethonium, succinylcholine, gallamine and pancuronium each of which contain quaterhary ammonium gr...... hiện toàn bộ
Influence of chronic inflammation and autoimmunity on coronary calcifications and myocardial perfusion defects in systemic lupus erythematosus patients
Agents and Actions - Tập 60 - Trang 973-980 - 2011
Wojciech Plazak, Mieczyslaw Pasowicz, Magdalena Kostkiewicz, Jakub Podolec, Lidia Tomkiewicz-Pajak, Jacek Musial, Piotr Podolec
Conventional risk factors for coronary artery disease fail to explain the increased frequency or cardiovascular morbidity in systemic lupus erythematosus (SLE) patients. This study was conducted to determine the possible influence of autoimmune and inflammatory phenomena markers on coronary artery calcifications and myocardial perfusion abnormalities in SLE patients. Multi-detector computed tomogr...... hiện toàn bộ
Important role of CD18 in TNF-α-induced leukocyte adhesion in muscle and skin venules in vivo
Agents and Actions - Tập 49 - Trang 529-534 - 2000
X.W. Zhang, R. Schramm, Q. Liu, H. Ekberg, B. Jeppsson, H. Thorlacius
Objective: To examine the role of CD18 in tumor necrosis factor-α (TNF-α)-induced leukocyte adhesion and extravasation in vivo.¶Material: Male wild-type (WT) and mutated mice with hypomorphic expression of CD18.¶Methods: Intravital microscopy was used to quantitate leukocyte-endothelium interactions provoked by TNF-α (0.5 μg) in the cremaster muscle and dorsal skin microc...... hiện toàn bộ
Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation
Agents and Actions - Tập 21 - Trang 149-159 - 1987
G. M. Strathy, J. P. Gorski
Effects of aspirin (200 μg/ml), hydrocortisone (10 μg/ml), sodium aurothiomalate (100 μg/ml), and indomethacin (10 μg/ml) on recovery of cartilage from interleukin 1 or catabolin-induced degradation were examined in this initialin vitro study. The experimental protocol involved a “degradative phase” of eight days during which cartilage plugs were incubated in the presence or absence of spent human...... hiện toàn bộ
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