Agents and Actions
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Sắp xếp:
Histamine and acute haemorrhagic lesions in rat gastric mucosa: Prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro
Agents and Actions - Tập 7 - Trang 69-73 - 1977
Acute haemorrhagic lesions in the oesophagus, stomach and duodenum (‘stress ulcers’) occur relatively often under clinical conditions and are always dangerous to the patient (lethality rate about 70%). Since conservative and surgical treatment are without significant success up to now, prevention by adaptation to stressors or by administration of drugs seems mandatory. An improved technique for pr...... hiện toàn bộ
Effect of adjuvant arthritis on the disposition of acebutolol enantiomers in rats
Agents and Actions - Tập 37 - Trang 290-296 - 1992
Disease states such as arthritis may interact with the kinetics of β-blockers. Acebutolol (AC) is a chiral β-blocker which is available as a racemate. The beneficial properties of AC, however, is attributed mainly to theS-(+)-enantiomer. The disposition of AC enantiomers and their active, chiral metabolites, diacetolol (DC) were examined after oral administration to healthy and adjuvant-induced ar...... hiện toàn bộ
Interaction between α1 antitrypsin and lymphocyte surface proteases: immunoregulatory effects
Agents and Actions - Tập 11 - Trang 614-616 - 1981
Alpha 1 antitrypsin (α1-AT) is the major plasma protease inhibitor. Radioiodinated α1-AT binds to human lymphocytes. The binding is fast and reversible, and the cells can be saturated with a maximum of approximately 1.2×106 molecules of α1-AT per lymphocyte. The receptor for α1-AT is a surface-associated protease. Adition of α1-AT completely inhibits cell surface proteolytic activity. Furthermore ...... hiện toàn bộ
Mustard oil-induced cutaneous inflammation in the pig
Agents and Actions - Tập 39 - Trang 31-34 - 1993
Recent findings indicate that chemical stimulation of the porcine skin with capsaicin evokes a flare response similar to that observed in man. The aim of the present study was to elucidate whether chemical stimulation of cutaneous capsaicin-sensitive nerve endings with mustard oil produces neurogenic inflammatory reactions in the pig. The application of mustard oil onto the abdominal skin of domes...... hiện toàn bộ
Impairment of inflammatory response in adult rats submitted to maternal undernutrition during early lactation: Role of insulin and glucocorticoid
Agents and Actions - - 2003
Toll-like receptor expression in chronic hepatitis C: Correlation with pro-inflammatory cytokine levels and liver injury
Agents and Actions - Tập 55 - Trang 279-285 - 2006
Toll-like receptors (TLR’s) are critical receptors that promote innate immune responses to pathogen-associated molecular patterns. Activation of TLR’s leads to production of pro-inflammatory cytokines such as tumour necrosis factor (TNF)-α. This study investigates whether peripheral blood monocyte expression of TLR’s is disturbed in patients with chronic hepatitis C and whether levels of expressio...... hiện toàn bộ
The effect of calcium on cardiac anaphylaxis in guinea-pig Langendorff heart preparations
Agents and Actions - Tập 16 - Trang 415-424 - 1985
This study was designed to determine the effects of different calcium concentrations on the perfused isolated guinea-pig heart preparation subjected to cardiac anaphylaxis. Following challenge both physiological and biochemical effects were determined on hearts from guinea-pigs previously sensitized to ovalbumin. Perfusion media containing either 1, 2.54 or 5 mM of calcium was used. In comparison ...... hiện toàn bộ
Inhibitory effects of epi-sesamin on endothelial protein C receptor shedding in vitro and in vivo
Agents and Actions - Tập 62 - Trang 895-902 - 2013
Endothelial protein C receptor (EPCR) plays a pivotal role in augmenting Protein C activation by the thrombin–thrombomodulin complex. The activity of EPCR is markedly changed by ectodomain cleavage and release as the soluble protein (sEPCR). The EPCR shedding is mediated by the tumor necrosis factor-α converting enzyme (TACE). Epi-sesamin (ESM), from the roots of Asarum siebodlii, is known to exhi...... hiện toàn bộ
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