H1-receptor dependent increase in platelet aggregation is mediated by intracellular calcium
Tóm tắt
The influence of histamine on human platelet function was studied by measuring the uptake of [3H]-histamine and by evaluating the effect of histamine on Ca2+ influx and on intracellular Ca2+ levels. The uptake of histamine by platelets is significantly reduced by mepyramine and unaffected by cimetidine. Histamine was found to increase both the [45Ca]2+ uptake by resting and stimulated platelets, and the intracellular Ca2+ levels in Fura 2-AM loaded platelets. H1-antihistaminics significantly reduced these processes, suggesting a role for histamine, which in platelets promotes aggregation by acting through H1-receptors modulating intracellular Ca2+ levels.
Tài liệu tham khảo
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