AAPS PharmSciTech

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Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles
AAPS PharmSciTech - Tập 16 - Trang 1235-1244 - 2015
Rana M. Obaidat, Bassam M. Tashtoush, Mohammad F. Bayan, Rana T. Al Bustami, Mohammad Alnaief
Supercritical fluid technology offers several advantages in preparation of microparticles. These include uniformity in particle size, morphology, and drug distribution without degradation of the product. One of the recent advantages is preparation of porous aerogel carrier with proper aerodynamic properties. In this study, we aimed to prepare chitosan aerogel microparticles using supercritical flu...... hiện toàn bộ
Melt-in-Mouth Multi-particulate System for the Treatment of ADHD: A Convenient Platform for Pediatric Use
AAPS PharmSciTech - Tập 17 - Trang 878-890 - 2015
Jalashri Patadia, Rahul Tripathi, Amita Joshi
Generally, pellets obtained from extrusion/spheronization, containing microcrystalline cellulose (MCC), do not disintegrate. An attempt has been made to develop melt-in-mouth pellets of taste-masked atomoxetine hydrochloride, using extrusion-spheronization, for pediatric patients. Melt-in-mouth pellets were prepared using extrusion-spheronization method and optimized using 33 FFD. MCC (X1, %), man...... hiện toàn bộ
ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation
AAPS PharmSciTech - Tập 24 Số 8
Pooja Khairnar, Ajit Singh, Kailash Ahirwar, Rahul Shukla
A preliminary pharmacokinetic study of liposomal leuprolide dry powder inhaler: A technical note
AAPS PharmSciTech - Tập 6 - Trang E482-E486 - 2005
Aliasgar Shahiwala, Ambikanandan Misra
The developed liposomal DPI of LEU (LLEUn-DPI) demonstrated approximately 50% bioavailability compared with SC route. The studies justify the role of the pulmonary route as a promising alternative to the presently available SC route. The components of liposomal vesicles may be suitably changed to achieve higher bioavailability. Pulmonary delivery of LEU is expected to help in improving patient com...... hiện toàn bộ
Vacuum foam drying for preservation of LaSota virus: Effect of additives
AAPS PharmSciTech - Tập 7 - Trang E30-E37 - 2017
Sambhaji Pisal, Gopal Wawde, Shailendra Salvankar, Sanjay Lade, Shivajirao Kadam
The purpose of this research was to apply vacuum foam drying (VFD) for processing of LaSota virus and to screen formulation additives for its stability. The aqueous dispersion of harvest containing sucrose or trehalose in combination with additive (monosaccharides, polymers, N-Z-amine) was prepared. The diluted dispersions in vials were vacuum concentrated, foamed to form a continuous structure, a...... hiện toàn bộ
A Feasibility Study on Pellet Coating Using a High-Speed Quasi-continuous Coater
AAPS PharmSciTech - - 2012
Christine Cahyadi, Jackson Jie Sheng Koh, Zhi Hui Loh, Lai Wah Chan, Paul Wan Sia Heng
A Novel Thermal-driven Self-assembly Method to Prepare Albumin Nanoparticles: Formation Kinetics, Degradation Behavior and Formation Mechanism
AAPS PharmSciTech - Tập 23 - Trang 1-15 - 2022
Fang Li, Stacy Yeh, Qin Shi, Peng Wang, Hongyan Wu, Junbo Xin
Nanoparticles based on bovine serum albumin (BSA), which shares 76% homology with human serum albumin (HSA), have emerged as a promising candidate for the efficient delivery of anticancer drugs. Thermal-driven self-assembly is a novel organic solvent-free approach to produce albumin nanoparticles. In our previous study, some features of this nanoparticle such as drug loading efficiency, drug encap...... hiện toàn bộ
Effect of Counterions on Physicochemical Properties of Prazosin Salts
AAPS PharmSciTech - Tập 14 - Trang 141-150 - 2012
Lokesh Kumar, Chhuttan Lal Meena, Yogesh B. Pawar, Banrida Wahlang, Kulbhushan Tikoo, Rahul Jain, Arvind K. Bansal
This study evaluated the effect of counterions on the physicochemical properties of prazosin salts. Salt forms of prazosin, namely, mesylate, besylate, tosylate, camsylate, oxalate, and maleate, were prepared and compared with the marketed anhydrous and polyhydrate forms of prazosin hydrochloride. Physicochemical characterization was performed in the order of crystallinity, hygroscopicity, solubil...... hiện toàn bộ
Glutamine-Loaded Liposomes: Preliminary Investigation, Characterization, and Evaluation of Neutrophil Viability
AAPS PharmSciTech - Tập 17 - Trang 446-453 - 2015
Larissa Chaves Costa, Bárbara Nayane Rosário Fernandes Souza, Fábio Fidélis Almeida, Cláudia Jacques Lagranha, Pabyton Gonçalves Cadena, Nereide Stela Santos-Magalhães, Mariane Cajubá de Britto Lira-Nogueira
Glutamine has received attention due to its ability to ameliorate the immune system response. Once conventional liposomes are readily recognized and captured by immune system cells, the encapsulation of glutamine into those nanosystems could be an alternative to reduce glutamine dosage and target then to neutrophils. Our goals were to nanoencapsulate glutamine into conventional liposomes (Gln-L), ...... hiện toàn bộ
Methotrexate-Loaded Chitosan- and Glycolchitosan-Based Nanoparticles: A Promising Strategy for the Administration of the Anticancer Drug to Brain Tumors
AAPS PharmSciTech - Tập 12 - Trang 1302-1311 - 2011
Adriana Trapani, Nunzio Denora, Giuliano Iacobellis, Johannes Sitterberg, Udo Bakowsky, Thomas Kissel
Brain tumor treatment employing methotrexate (MTX) is limited by the efflux mechanism of Pg-p on the blood–brain barrier. We aimed to investigate MTX-loaded chitosan or glycol chitosan (GCS) nanoparticles (NPs) in the presence and in the absence of a coating layer of Tween 80 for brain delivery of MTX. The effect of a low Tween 80 concentration was evaluated. MTX NPs were formulated following the ...... hiện toàn bộ
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