AAPS PharmSciTech
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A preliminary pharmacokinetic study of liposomal leuprolide dry powder inhaler: A technical note
AAPS PharmSciTech - Tập 6 - Trang E482-E486 - 2005
The developed liposomal DPI of LEU (LLEUn-DPI) demonstrated approximately 50% bioavailability compared with SC route. The studies justify the role of the pulmonary route as a promising alternative to the presently available SC route. The components of liposomal vesicles may be suitably changed to achieve higher bioavailability. Pulmonary delivery of LEU is expected to help in improving patient com...... hiện toàn bộ
99mTc Stearyl 6-(benzylidenehydrazinyl) nicotinamide Liposomes as Tumor Permeability Evaluation Tracer
AAPS PharmSciTech - - 2021
Decision Support for Excipient Risk Assessment in Pharmaceutical Manufacturing
AAPS PharmSciTech - Tập 20 - Trang 1-16 - 2019
Excipients have always been a key input into pharmaceutical products, profoundly affecting product quality. Currently, most of our knowledge of excipient critical quality attributes is empirical, gained through experience, and shared through publications and other sources. The behavior of excipients is complicated, with many different failure modes that depend on the type of dosage form. Even with...... hiện toàn bộ
Design and Mechanism of On–Off Pulsed Drug Release Using Nonenteric Polymeric Systems via pH Modulation
AAPS PharmSciTech - Tập 12 - Trang 46-55 - 2010
The aim was to design a pH-sensitive pulsatile drug delivery system that allows for an on–off pulsed release of a drug using polyacrylic acid (PAA) blended with ethyl cellulose (EC) in different ratios. PAA, a polyelectrolyte polymer, exhibits a highly coiled conformation at low pH but a highly extended structure at high pH. Fumaric acid, which is an internal acidifying agent, was incorporated int...... hiện toàn bộ
IVIVC of Octreotide in PLGA-Glucose Microsphere Formulation, Sandostatin® LAR
AAPS PharmSciTech - Tập 23 - Trang 1-11 - 2022
In vitro-in vivo correlation (IVIVC) analysis reveals a relationship between in vitro release and in vivo pharmacokinetic response of the drug of interest. Sandostatin LAR Depot (SLD) for endocrine tumors and acromegaly is a sustained-release formulation of octreotide, a cyclic oligomer of 8 amino acids, which prolongs therapeutic efficacy and enhances medication compliance of octreotide. Since th...... hiện toàn bộ
Assessing Drug Release from Manipulated Abuse Deterrent Formulations
AAPS PharmSciTech - Tập 21 - Trang 1-11 - 2020
There is a need to develop in vitro
dissolution methods that discriminate for particle size of the manipulated abuse
deterrent formulation (ADF) and that can be used for in
vivo predictive models since dissolution methods developed for intact
formulation might not be suitable for manipulated ones. A vertical diffusion cell
(VDC) and United States Pharmacopeia (USP) Apparatus 1, 2, and 4 were evalu...... hiện toàn bộ
A Novel Approach in Distinguishing Between Role of Hydrodynamics and Mechanical Stresses Similar to Contraction Forces of GI Tract on Drug Release from Modified Release Dosage Forms
AAPS PharmSciTech - Tập 16 - Trang 278-283 - 2014
The objective of this study was to determine the influence of mechanical stresses simulating gastrointestinal contraction forces of 2.0 N (stomach) and 1.2 N (intestine) on the gel properties and drug release characteristics from sustained release swelling and eroding hydrophilic matrices during dissolution studies. Two batches of tetracycline-sustained release tablets containing hydroxypropyl met...... hiện toàn bộ
Membrane-Loaded Doxorubicin Liposomes Based on Ion-Pairing Technology with High Drug Loading and pH-Responsive Property
AAPS PharmSciTech - - 2017
An Investigation of Magnesium Stearate Mixing Performance in a V-Blender Through Passive Vibration Measurements
AAPS PharmSciTech - Tập 20 - Trang 1-9 - 2019
Prior to compression in tablet manufacturing, a lubricant is added and mixed in a V-blender to ensure the mixture is ejected from the tablet die smoothly. Mixing is conducted batch-wise and must be analyzed offline afterwards to ensure the mixture is uniform and will produce desired tablet properties, thereby a costly and time-consuming step within the manufacturing process. To improve process eff...... hiện toàn bộ
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