von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD

Blood Advances - Tập 3 - Trang 4147-4154 - 2019
Ferdows Atiq1, Lisette M. Schütte1, Agnes E.M. Looijen1, Johan Boender1, Marjon H. Cnossen2, Jeroen Eikenboom3,4, Moniek P.M. de Maat1, Marieke J. H.A. Kruip1, Frank W.G. Leebeek1
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;
2Department of Pediatric Hematology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, The Netherlands
3Division of Thrombosis and Hemostasis, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
4Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands

Tóm tắt

Key Points VWF and FVIII levels after desmopressin, which mimic hemostatic response, are associated with the bleeding phenotype of type 1 VWD patients. Variability in VWF and FVIII response to hemostatic challenges may partly explain heterogeneity in bleeding phenotype of VWD patients.

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Blood Advances

Tập 3

4147-4154

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