pH control strategy in a shaken minibioreactor for polysaccharide production by medicinal mushroom Phellinus linteus and its anti-hyperlipemia activity

Xiang Zou1, Xusheng Guo1, Min Sun2
1School of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China
2School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Li G, Kim DH, Kim TD, Park BJ, Park HD, Park JI, Na MK, Kim HC, Hong ND, Lim K (2004) Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells. Cancer Lett 216:175–181

Kim GY, Lee JY, Lee JO, Ryu CH, Choi BT, Jeong YK, Lee KW, Jeong SC, Choi YH (2006) Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci Biotech Bioch 70:1218–1226

Sliva D, Kawasaki J, Stanley G, Harvey K, Slivova V (2006) Phellinus linteus inhibits growth and invasive behavior of breast cancer cells through the suppression of Akt signaling. FASEB J 20:559–560

Kim BC, Jeon WK, Hong HY, Jeon KB, Hahn JH, Kim YM, Numazawa S, Yosida T, Park EH, Lim CJ (2007) The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKC[delta]/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. J Ethnopharmacol 113:240–247

Park IH, Chung SK, Lee KB, Yoo YC, Kim SK, Kim GS, Song KS (2004) An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch Pharm Res 27:615–618

Zou X, Sun M, Guo X (2006) Quantitative response of cell growth and polysaccharide biosynthesis by the medicinal mushroom Phellinus linteus to NaCl in the medium. World J Microb Biot 22:1129–1133

Xiao JH, Chen DX, Wan WH, Hu XJ, Qi Y, Liang ZQ (2006) Enhanced simultaneous production of mycelia and intracellular polysaccharide in submerged cultivation of Cordyceps jiangxiensis using desirability functions. Process Biochem 41:1887–1893

Fan LF, Soccol AT, Pandey A, Soccol CR (2007) Effect of nutritional and environmental conditions on the production of exo-polysaccharide of Agaricus brasiliensis by submerged fermentation and its antitumor activity. Lwt-Food Sci Technol 40:30–35

Lin ES, Sung SC (2006) Cultivating conditions influence exopolysaccharide production by the edible basidiomycete Antrodia cinnamomea in submerged culture. Int J Food Microbiol 108:182–187

Kim HM, Park MK, Yun JW (2006) Culture pH affects exopolysaccharide production in submerged mycelial culture of Ganoderma lucidum. Appl Biochem Biotech 134:249–262

Lee KM, Lee SY, Lee HY (1999) Biostage control of pH for improving exopolysaccharide production from mycelia of Ganoderma lucidum in an air-lift fermentor. J Biosci Bioeng 6:646–650

Fang QH, Zhong JJ (2002) Effect of initial pH on production of ganoderic acid and polysaccharide by submerged fermentation of Ganoderma lucidum. Process Biochem 37:769–774

Pokhrel CP, Ohga S (2007) Submerged culture conditions for mycelial yield and polysaccharides production by Lyophyllum decastes. Food Chem 105:641–646

Kim SW, Hwang HJ, Xu CP, Sung JM, Choi JW, Yun JW (2003) Optimization of submerged culture process for the production of mycelial biomass and exo-polysaccharides by Cordyceps militaris C738. J Appl Microbiol 94:120–126

Betts JI, Baganz F (2006) Miniature bioreactors: current practices and future opportunities. Microb Cell Fact 5:21–35

Fernandes P, Cabral JMS (2006) Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes a review. Biocatal Biotransfor 24:237–252

Miller GL (1959) Use of dinitrosalicylic acid reagent for determ ination of reducing sugar. Anal Chem 31:426–428

Dmgkahjkrpas F (1956) Colorimetric method for determination of sugars and related substances. Anal Chem 28:350–356

Xiao JH, Liu JW, Liu ZL, Wan WH, Fang N, Xiao Y, Qi Y, Liang ZQ (2004) Optimization of submerged culture requirments for production of mycelial growth and exopolysaccharide by Cordyceps jiangxiensis JXP 0109. J Appl Microbiol 96:1105–1116