Nanxin Li1, Boyoung Lee1, Rongjian Liu1, Mounira Banasr1, Jason M. Dwyer1, Masaaki Iwata1, Xiao‐Yuan Li1, George K. Aghajanian1, Ronald S. Duman1
1Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA.
Tóm tắt
Antidepressant Action of Ketamine
In contrast to the weeks or months of treatment required for standard antidepressant medication, ketamine administration produces an antidepressant response within 4 to 6 hours in depressed patients. What lies behind the rapid actions of ketamine?
Li
et al.
(p.
959
; see the Perspective by
Cryan and O'Leary
) found that ketamine administration resulted in fast activation of mammalian target of rapamycin (mTOR) signaling and increased levels of synaptic proteins in the rat prefrontal cortex. Ketamine rapidly increased the density and function of the dendritic spines of layer V pyramidal neurons in the prefrontal cortex. Thus, the behavioral actions of ketamine in models of depression and antidepressant response are dependent on mTOR signaling.
