Zur Festphasenpeptidsynthese des Makrophagen-migrationsinhibierenden Faktors der Maus (mMIF): Ein Vergleich verschiedener Syntheseansätze zur Darstellung der schwierigen C-terminalen Sequenz mMIF(93-115)/ Solid Phase Peptide Synthetic Approaches to Mouse Macrophage Migration Inhibitory Factor (mMIF): Comparison of Different Strategies Producing the C-Terminal Difficult Sequence Peptide mMIF (93-115)

Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences - Tập 52 Số 2 - Trang 281-295 - 1997
Thomas Kaiser1, Wolfgang Voelter1
1Abteilung für Physikalische Biochemie des Physiologisch-chemischen Instituts der Universität Tübingen, Hoppe-Seyler-Straße 4, D-72076 Tübingen

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Abstract From solid phase peptide synthetic approaches of mMIF(93-115) the C-terminal sequence turned out to be a typical „difficult sequence“ peptide. Various stepwise syntheses were performed with different resins and coupling reagents. The Peptide was synthesized in 90% yield by solid phase fragment condensation of protected mMIF(93-108) to mMIF(109-115) ‘2-Chlorotrityl’ resin bound.

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Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

Tập 52 Số 2

281-295

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