Zinc and Oxidative Stress: Current Mechanisms
Tóm tắt
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases.
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Tài liệu tham khảo
Butterfield, 2014, Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain, Biochim. Biophys. Acta, 1824, 1693, 10.1016/j.bbadis.2014.06.010
Feng, 2013, Oxidative-stress-induced epigenetic changes in chronic diabetic complications, Can. J. Physiol. Pharmacol., 91, 213, 10.1139/cjpp-2012-0251
Pisoschi, 2015, The role of antioxidants in the chemistry of oxidative stress: A review, Eur. J. Med. Chem., 97, 55, 10.1016/j.ejmech.2015.04.040
Roshanravan, 2015, Effect of zinc supplementation on insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance, Iran J. Public Health, 44, 211
Jurowski, 2014, Biological consequences of zinc deficiency in the pathomechanisms of selected diseases, J. Biol. Inorg. Chem., 19, 1069, 10.1007/s00775-014-1139-0
Foster, 2014, Zinc transporter gene expression and glycemic control in post-menopausal women with type 2 diabetes mellitus, J. Trace Elem. Med. Biol., 28, 448, 10.1016/j.jtemb.2014.07.012
Fung, 2015, Zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia, Nutrients, 7, 4296, 10.3390/nu7064296
Jansen, 2012, Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc, J. Nutr. Biochem., 23, 1458, 10.1016/j.jnutbio.2011.09.008
Ruz, 2013, Zinc as a potential coadjuvant in therapy for type 2 diabetes, Food Nutr. Bull., 34, 215, 10.1177/156482651303400210
Chasapis, 2012, Zinc and human health: An update, Arch. Toxicol., 86, 521, 10.1007/s00204-011-0775-1
Cruz, 2015, Antioxidant role of zinc in diabetes mellitus, World J. Diabetes, 6, 333, 10.4239/wjd.v6.i2.333
Lima, 2011, Parameters of glycemic control and their relationship with zinc concentrations in blood and with superoxide dismutase enzyme activity in type 2 diabetes patients, Arq. Bras. Endocrinol. Metab., 55, 701, 10.1590/S0004-27302011000900006
Cruz, 2011, Uma revisão sobre o zinco, Ensaios Ciência Ciências Biológicas Agrárias Saúde, 15, 207
Homma, 2013, SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency, Mol. Cell., 52, 75, 10.1016/j.molcel.2013.08.038
Ha, 2006, Increased glutathione synthesis through an ARE-Nrf2-dependent pathway by zinc in the RPE: Implication for protection against oxidative stress, Investig. Ophthalmol. Vis. Sci., 47, 2709, 10.1167/iovs.05-1322
Foster, 2010, Zinc and redox signaling: Perturbations associated with cardiovascular disease and diabetes mellitus, Antioxid. Redox. Signal., 13, 1549, 10.1089/ars.2010.3111
Maret, 2007, Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease, Mol. Med., 13, 371, 10.2119/2007-00036.Maret
2012, Zinc supplementation attenuates metallothionein and oxidative stress changes in kidney of streptozotocin-induced diabetic rats, Biol. Trace Elem. Res., 150, 342, 10.1007/s12011-012-9508-4
Liang, 2015, Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein, Toxicol. Lett., 233, 114, 10.1016/j.toxlet.2015.01.010
Coyle, 2002, Methallothionein: The Multipurpose Protein, Cell Mol. Life Sci., 59, 627, 10.1007/s00018-002-8454-2
Davis, 2012, A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1), Biochim. Biophys. Acta, 1823, 476, 10.1016/j.bbamcr.2011.10.006
Lindert, 2012, The taste of heavy metals: Gene regulation by MTF-1, Biochim. Biophys. Acta, 1823, 1416, 10.1016/j.bbamcr.2012.01.005
Andrews, 2000, Regulation of metallothionein gene expression by oxidative stress and metal ions, Biochem. Pharmacol., 59, 95, 10.1016/S0006-2952(99)00301-9
Sekler, 2007, Mechanism and regulation of cellular zinc transport, Mol. Med., 13, 337, 10.2119/2007-00037.Sekler
Bonaventura, 2015, Zinc and its role in immunity and inflammation, Autoimmunity Rev., 14, 277, 10.1016/j.autrev.2014.11.008
Grzywacz, 2015, Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level, Acta Biochim. Pol., 62, 491, 10.18388/abp.2015_1038
Oteiza, 2012, Zinc and the modulation of redox homeostasis, Free Radic. Biol. Med., 53, 1748, 10.1016/j.freeradbiomed.2012.08.568
Bryan, 2013, Redox-inflammatory synergy in the metabolic syndrome, Can. J. Physiol. Pharmacol., 91, 22, 10.1139/cjpp-2012-0295
Prasad, 2011, Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB, Nutrition, 27, 816, 10.1016/j.nut.2010.08.010
Bao, 2010, Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: A potential implication of zinc as an atheroprotective agent, Am. J. Clin. Nutr., 91, 1634, 10.3945/ajcn.2009.28836
Biagiotti, S., and Menotta, M. (2016). Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response. FEBS J.
Jenner, 2007, Zinc supplementation inhibits lipid peroxidation and the development of atherosclerosis in rabbits fed a high cholesterol diet, Free Radic. Biol. Med., 42, 559, 10.1016/j.freeradbiomed.2006.11.024
Miao, 2013, Zinc protects against diabetes-induced pathogenic changes in the aorta: Roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2, Cardiovasc. Diabetol., 12, 54, 10.1186/1475-2840-12-54
Weglicki, 2011, Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiency, Am. J. Med. Sci., 342, 125, 10.1097/MAJ.0b013e318222e88c
Ranasinghe, 2015, Zinc and diabetes mellitus: Understanding molecular mechanisms and clinical implications, Daru, 23, 44, 10.1186/s40199-015-0127-4
Vardatsikos, 2013, Insulino-mimetic and anti-diabetic effects of zinc, J. Inorg. Biochem., 120, 8, 10.1016/j.jinorgbio.2012.11.006
Liang, 2013, ZnT7 can protect MC3T3-E1 cells from oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK signaling pathways, Cell Signal., 25, 1126, 10.1016/j.cellsig.2013.02.003
Sun, Q., and Li, Q. (2014). Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol., 313–322.
Aydemir, T.B., and Chang, S.M. (2012). Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS ONE, 7.
Kirschke, 2003, ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus, J. Biol. Chem., 278, 4096, 10.1074/jbc.M207644200
Taylor, 2004, Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters, Biochem. J., 377, 131, 10.1042/bj20031183
Sun, 2015, Zinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathways, Am. J. Physiol. Gastrointest. Liver Physiol., 308, 757, 10.1152/ajpgi.00442.2014
Maret, 2013, Zinc biochemistry: From a single zinc enzyme to a key element of life, Adv. Nutr., 4, 82, 10.3945/an.112.003038
Maret, 2006, Zinc requirements and the risks and benefits of zinc supplementation, J. Trace Elem. Med. Biol., 20, 3, 10.1016/j.jtemb.2006.01.006
Maret, 2008, Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc, Exp. Gerontol., 43, 363, 10.1016/j.exger.2007.11.005
Martins, 2014, Influence of cortisol on zinc metabolism in morbidly obese women, Nutr. Hosp., 29, 57
Sulibuska, 2014, Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation, Eur. J. Nutr., 53, 387, 10.1007/s00394-013-0533-7
Habib, 2015, Pro-inflammatory adipocytokines, oxidative stress, insulin, Zn and Cu: Interrelations with obesity in Egyptian non-diabetic obese children and adolescents, Adv. Med. Sci., 60, 179, 10.1016/j.advms.2015.02.002
Tonelli, M.N., and Wiebe, H.B. (2009). Trace elements in hemodialysis patients: A systematic review and meta-analysis. BMC Med., 7.
2011, Nutritional status of zinc and activity superoxide dismutase in chronic renal patients undergoing hemodialysis, Nutr. Hosp., 26, 1456
Guo, 2013, Effects of zinc supplementation on plasma copper/zinc ratios, oxidative stress, and immunological status in hemodialysis patients, Int. J. Med. Sci., 10, 79, 10.7150/ijms.5291
Sensi, 2011, The neurophysiology and pathology of brain zinc, J. Neurosci., 31, 16076, 10.1523/JNEUROSCI.3454-11.2011
Vergnano, 2014, Zinc dynamics and action at excitatory synapses, Neuron, 82, 1101, 10.1016/j.neuron.2014.04.034
Oliveira, 2015, Magnesium Status and Its Relationship with C-Reactive Protein in Obese Women, Biol. Trace Elem. Res., 168, 296, 10.1007/s12011-015-0358-8
Prabasheela, 2011, Association between Antioxidant Enzymes and Breast Cancer, Rec. Res. Sci. Tech., 3, 93
Bostanci, 2015, Paradoxical zinc toxicity and oxidative stress in the mammary gland during marginal dietary zinc deficiency, Reprod. Toxicol., 54, 84, 10.1016/j.reprotox.2014.07.076
Alam, 2012, Cellular mechanisms of zinc dysregulation: A perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer, Nutrients, 4, 875, 10.3390/nu4080875
Kim, 2002, The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly (ADP-ribose) polymerase activation and cell death in cortical culture, Exp. Neurol., 177, 407, 10.1006/exnr.2002.7990
Higashi, 2011, Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia, Glia, 59, 1933, 10.1002/glia.21235
Furuta, 2016, Oxidative stress upregulates zinc uptake activity via Zrt/Irt-like protein 1 (ZIP1) in cultured mouse astrocytes, Life Sci., 151, 305, 10.1016/j.lfs.2016.03.025