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We thank C. Riekel H. Belrahli and A. Bram for invaluable help on the ID13 beamline; E. Fanchon R. Kahn and M. Roth on the French beamline D2AM; G. Büldt for his generosity; G. Büldt S. Cusack O. Dideberg J. Heberle J. Sass and G. Zaccai for stimulating discussions; and T. Bickle and R. Eisenberg for critically reading the manuscript. Supported by the Université Joseph Fourier the Institut de Biologie Structurale the Institut Universitaire de France the University of Basel and grants from the Swiss National Science Foundation (SPP 5002-37911 and -46092) EU-BIOMED (BIO4CT96/BBW95.0137.2) and EU-BIOTECH (EU-BIO4CT96/BBW96.0145.1). Beam time at the ESRF (Grenoble France) was granted under experiments LS-435 LS-553 LS-655 02.03.060 and 02.03.111.