Chặn C tín hiệu Wnt/β-Catenin Kích Thích Định Hình Nơ-ron và Phân Hóa Đôpamin trong Tế Bào Gốc Phôi
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Tài liệu tham khảo
Parish, 2007, Stem-cell-based strategies for the treatment of Parkinson's disease, Neurodegener Dis, 4, 339, 10.1159/000101892
Ciani, 2005, WNTs in the vertebrate nervous system: From patterning to neuronal connectivity, Nat Rev Neurosci, 6, 351, 10.1038/nrn1665
Ille, 2005, Wnt signaling: Multiple functions in neural development, Cell Mol Life Sci, 62, 1100, 10.1007/s00018-005-4552-2
Gaulden, 2008, Neur-ons and neur-offs: Regulators of neural induction in vertebrate embryos and embryonic stem cells, Hum Mol Genet, 17, R60, 10.1093/hmg/ddn119
Castelo-Branco, 2006, Function of Wnts in dopaminergic neuron development, Neurodegener Dis, 3, 5, 10.1159/000092086
Castelo-Branco, 2003, Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a, Proc Natl Acad Sci U S A, 100, 12747, 10.1073/pnas.1534900100
Parish, 2008, Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice, J Clin Invest, 118, 149, 10.1172/JCI32273
Panhuysen, 2004, Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region, Mol Cell Neurosci, 26, 101, 10.1016/j.mcn.2004.01.011
McMahon, 1990, The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain, Cell, 62, 1073, 10.1016/0092-8674(90)90385-R
Thomas, 1990, Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development, Nature, 346, 847, 10.1038/346847a0
Joksimovic, 2009, Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis, Nat Neurosci, 10.1038/nn.2243
Prakash, 2006, A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo, Development, 133, 89, 10.1242/dev.02181
Kohn, 2005, Wnt and calcium signaling: beta-catenin-independent pathways, Cell Calcium, 38, 439, 10.1016/j.ceca.2005.06.022
Seifert, 2007, Frizzled/PCP signalling: A conserved mechanism regulating cell polarity and directed motility, Nat Rev Genet, 8, 126, 10.1038/nrg2042
Semenov, 2007, SnapShot: Noncanonical Wnt Signaling Pathways, Cell, 131, 1378, 10.1016/j.cell.2007.12.011
Andersson, 2008, Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo, Plos One, 3, e3517, 10.1371/journal.pone.0003517
Kawano, 2003, Secreted antagonists of the Wnt signalling pathway, J Cell Sci, 116, 2627, 10.1242/jcs.00623
Bryja, 2006, An efficient method for the derivation of mouse embryonic stem cells, Stem Cells, 24, 844, 10.1634/stemcells.2005-0444
Parisi, 2003, Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells, J Cell Biol, 163, 303, 10.1083/jcb.200303010
Barberi, 2003, Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice, Nat Biotechnol, 21, 1200, 10.1038/nbt870
Ying, 2003, Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture, Nat Biotechnol, 21, 183, 10.1038/nbt780
Parish, 2005, Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease, Stem Cells, 23, 471, 10.1634/stemcells.2004-0294
Bryja, 2005, Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator, Stem Cells, 23, 965, 10.1634/stemcells.2004-0174
Kawasaki, 2000, Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity, Neuron, 28, 31, 10.1016/S0896-6273(00)00083-0
Danielian, 1996, Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development, Nature, 383, 332, 10.1038/383332a0
Andersson, 2006, Identification of intrinsic determinants of midbrain dopamine neurons, Cell, 124, 393, 10.1016/j.cell.2005.10.037
Kittappa, 2007, The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age, Plos Biol, 5, e325, 10.1371/journal.pbio.0050325
He, 2004, LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way, Development, 131, 1663, 10.1242/dev.01117
Young, 1998, Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts, Mol Cell Biol, 18, 2474, 10.1128/MCB.18.5.2474
Bryja, 2007, Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin, Cell Signal, 19, 610, 10.1016/j.cellsig.2006.08.011
Gonzalez-Sancho, 2004, Wnt proteins induce dishevelled phosphorylation via an LRP5/6-independent mechanism, irrespective of their ability to stabilize beta-catenin, Mol Cell Biol, 24, 4757, 10.1128/MCB.24.11.4757-4768.2004
Jho, 2002, Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway, Mol Cell Biol, 22, 1172, 10.1128/MCB.22.4.1172-1183.2002
Yamaguchi, 1999, T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification, Genes Dev, 13, 3185, 10.1101/gad.13.24.3185
Arnold, 2000, Brachyury is a target gene of the Wnt/beta-catenin signaling pathway, Mech Dev, 91, 249, 10.1016/S0925-4773(99)00309-3
Castelo-Branco, 2004, GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons, J Cell Sci, 117, 5731, 10.1242/jcs.01505
Pinson, 2000, An LDL-receptor-related protein mediates Wnt signalling in mice, Nature, 407, 535, 10.1038/35035124
Tamai, 2000, LDL-receptor-related proteins in Wnt signal transduction, Nature, 407, 530, 10.1038/35035117
Wehrli, 2000, Arrow encodes an LDL-receptor-related protein essential for Wingless signalling, Nature, 407, 527, 10.1038/35035110
McMahon, 1989, Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis, Cell, 58, 1075, 10.1016/0092-8674(89)90506-0
Sokol, 1991, Injected Wnt RNA induces a complete body axis in Xenopus embryos, Cell, 67, 741, 10.1016/0092-8674(91)90069-B
Otero, 2004, Beta-catenin signaling is required for neural differentiation of embryonic stem cells, Development, 131, 3545, 10.1242/dev.01218
Aubert, 2002, Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation, Nat Biotechnol, 20, 1240, 10.1038/nbt763
Verani, 2007, Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid, J Neurochem, 100, 242, 10.1111/j.1471-4159.2006.04207.x
Semënov, 2001, Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6, Curr Biol, 11, 951, 10.1016/S0960-9822(01)00290-1
Bafico, 2001, Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow, Nat Cell Biol, 3, 683, 10.1038/35083081
Hayashi, 2008, Meningeal cells induce dopaminergic neurons from embryonic stem cells, Eur J Neurosci, 27, 261, 10.1111/j.1460-9568.2008.06027.x
Veeman, 2003, A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling, Dev Cell, 5, 367, 10.1016/S1534-5807(03)00266-1
Topol, 2003, Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation, J Cell Biol, 162, 899, 10.1083/jcb.200303158
Tahinci, 2007, Lrp6 is required for convergent extension during Xenopus gastrulation, Development, 134, 4095, 10.1242/dev.010272
Bryja, 2009, The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo, Mol Biol Cell, 20, 924, 10.1091/mbc.e08-07-0711
Clevers, 2006, Wnt/beta-Catenin Signaling in Development and Disease, Cell, 127, 469, 10.1016/j.cell.2006.10.018
White, 2007, Wnt signaling: It gets more humorous with age, Curr Biol, 17, R923, 10.1016/j.cub.2007.08.062