Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?

John M. Sedivy1, Jan M. van Deursen2
1Department of Molecular Biology Cell Biology and Biochemistry, Laboratories for Molecular Medicine, Brown University, 70 Ship Street, Providence, RI, 02903, USA
2Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Finch CE: Longevity, Senescence, and the Genome. 1990, Chicago: University of Chicago Press

Arking R: The Biology of Aging: Observations and Principles. 2006, Oxford: Oxford University Press, 3

Hayflick L, Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res. 1961, 25: 585-621. 10.1016/0014-4827(61)90192-6.

Shay JW, Wright WE: Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis. 2005, 26: 867-874.

Sedivy JM, Munoz-Najar UM, Jeyapalan JC, Campisi J: Cellular senescence: A link between tumor suppression and organismal aging?. In Molecular Biology of Aging. Edited by: Guarente L, Partridge L, Wallace DC. 2007, New York: Cold Spring Harbor Laboratory Press,

Kuilman T, Peeper DS: Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer. 2009, 9: 81-94.

Passos JF, Simillion C, Hallinan J, Wipat A, von Zglinicki T: Cellular senescence: unravelling complexity. Age (Dordr). 2009, 31: 353-363. 10.1007/s11357-009-9108-1.

Rodier F, Campisi J: Four faces of cellular senescence. J Cell Biol. 2011, 192: 547-556. 10.1083/jcb.201009094.

Sulli G, Di Micco R, d'Adda di Fagagna F: Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer. 2012, 12: 709-720.

Campisi J: Cellular senescence: putting the pdoxes in perspective. Curr Opin Genet Dev. 2011, 21: 107-112. 10.1016/j.gde.2010.10.005.

Collado M, Serrano M: Senescence in tumours: evidence from mice and humans. Nat Rev Cancer. 2010, 10: 51-57. 10.1038/nrc2772.

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM: Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011, 479: 232-236. 10.1038/nature10600.

Adams PD: Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell. 2009, 36: 2-14. 10.1016/j.molcel.2009.09.021.

Jun JI, Lau LF: Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov. 2011, 10: 945-963. 10.1038/nrd3599.