White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation

Springer Science and Business Media LLC - Tập 10 - Trang 1-8 - 2018
Charlotte E. Teunissen1, Markus Otto2, Sebastiaan Engelborghs3,4, Sanna-Kaisa Herukka5, Sylvain Lehmann6, Piotr Lewczuk7,8,9,10, Alberto Lleó11,12, Armand Perret-Liaudet13,14, Hayrettin Tumani15,16, Martin R. Turner17, Marcel M. Verbeek18, Jens Wiltfang19,20,21, Henrik Zetterberg22,23,24,25, Lucilla Parnetti26, Kaj Blennow22,23
1Neurochemistry Lab and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam, the Netherlands
2Department of Neurology, University of Ulm, Ulm, Germany
3Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
4Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, Antwerp, Belgium
5Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
6Université de Montpellier, University Hospital, INSERM U1183, Montpellier, France
7Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Germany
8[Friedrich–Alexander Universität Erlangen-Nürnberg, Erlangen, Germany]
9Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland
10Department of Biochemical Diagnostics, University Hospital of Białystok, Białystok, Poland
11Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau – Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
12Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
13Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Hospices Civils de Lyon, Lyon, France
14University of Lyon 1, CNRS UMR5292, INSERM U1028, BioRan, Lyon, France
15Department of Neurology, CSF Laboratory, MS Outpatient Unit, University Hospital of Ulm, Ulm, Germany
16Specialty Hospital of Neurology Dietenbronn, Acadamic Hospital of University of Ulm, Schwendi, Germany
17Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
18Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands
19Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University, Goettingen, Germany
20German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany
21iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal
22Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
23Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
24Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
25UK Dementia Research Institute at UCL, London, UK
26Center for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy

Tóm tắt

Body fluid biomarkers have great potential for different clinical purposes, including diagnosis, prognosis, patient stratification and treatment effect monitoring. This is exemplified by current use of several excellent biomarkers, such as the Alzheimer’s disease cerebrospinal fluid (CSF) biomarkers, anti-neuromyelitis optica antibodies and blood neurofilament light. We still, however, have a strong need for additional biomarkers and several gaps in their development and implementation should be filled. Examples of such gaps are i) limited knowledge of the causes of neurological diseases, and thus hypotheses about the best biomarkers to detect subclinical stages of these diseases; ii) the limited success translating discoveries obtained by e.g. initial mass spectrometry proteomic low-throughput studies into immunoassays for widespread clinical implementation; iii) lack of interaction among all stakeholders to optimise and adapt study designs throughout the biomarker development process to medical needs, which may change during the long period needed for biomarker development. The Society for CSF Analysis and Clinical Neurochemistry (established in 2015) has been founded as a concerted follow-up of large standardisation projects, including BIOMARKAPD and SOPHIA, and the BioMS-consortium. The main aims of the CSF society are to exchange high level international scientific experience, to facilitate the incorporation of CSF diagnostics into clinical practice and to give advice on inclusion of CSF analysis into clinical guidelines. The society has a broad scope, as its vision is that the gaps in development and implementation of biomarkers are shared among almost all neurological diseases and thus they can benefit from the activities of the society.

Tài liệu tham khảo

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