Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content

Nutrition Research - Tập 28 Số 10 - Trang 651-658 - 2008
Christos S. Katsanos1, David L. Chinkes2, Douglas Paddon‐Jones3, Xiaojun Zhang2, Asle Aarsland4, Robert R. Wolfe5
1Center for Metabolic Biology, Arizona State University, PO Box 873704, Tempe, AZ 85287-3704, USA
2Department of Surgery and Shriners Hospitals for Children-Galveston, University of Texas Medical Branch, Galveston, TX 77550, USA
3Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX 77550, USA
4Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77550, USA
5Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Wolfe, 2002, Regulation of muscle protein by amino acids, J Nutr, 132, 3219S, 10.1093/jn/131.10.3219S

Evans, 1995, What is sarcopenia?, J Gerontol A Biol Sci Med Sci, 50, 5, 10.1093/gerona/50A.Special_Issue.5

Roubenoff, 2000, Sarcopenia and its implications for the elderly, Eur J Clin Nutr, 54, S40, 10.1038/sj.ejcn.1601024

Boirie, 1997, Splanchnic and whole-body leucine kinetics in young and elderly men, Am J Clin Nutr, 65, 489, 10.1093/ajcn/65.2.489

Dangin, 2003, The rate of protein digestion affects protein gain differently during aging in humans, J Physiol, 549, 635, 10.1113/jphysiol.2002.036897

Katsanos, 2006, A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly, Am J Physiol Endocrinol Metab, 291, E381, 10.1152/ajpendo.00488.2005

Katsanos, 2005, Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids, Am J Clin Nutr, 82, 1065, 10.1093/ajcn/82.5.1065

Paddon-Jones, 2004, Amino acid ingestion improves muscle protein synthesis in the young and elderly, Am J Physiol Endocrinol Metab, 286, E321, 10.1152/ajpendo.00368.2003

Volpi, 1999, Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction, Am J Physiol, 277, E513

Volpi, 2003, Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults, Am J Clin Nutr, 78, 250, 10.1093/ajcn/78.2.250

Borsheim, 2002, Essential amino acids and muscle protein recovery from resistance exercise, Am J Physiol Endocrinol Metab, 283, E648, 10.1152/ajpendo.00466.2001

Koopman, 2006, Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men, Am J Clin Nutr, 84, 623, 10.1093/ajcn/84.3.623

Koopman, 2008, Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men, Br J Nutr, 99, 571, 10.1017/S0007114507812013

Paddon-Jones, 2006, Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein, Exp Gerontol, 41, 215, 10.1016/j.exger.2005.10.006

Jorfeldt, 1978, The influence of ethanol on splanchnic and skeletal muscle metabolism in man, Metabolism, 27, 97, 10.1016/0026-0495(78)90128-2

Jorfeldt, 1971, Leg blood flow during exercise in man, Clin Sci, 41, 459, 10.1042/cs0410459

Katsanos, 2005, Method for the determination of the arteriovenous muscle protein balance during non–steady-state blood and muscle amino acid concentrations, Am J Physiol Endocrinol Metab, 289, E1064, 10.1152/ajpendo.00141.2005

Rosenblatt, 1992, Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects, Am J Physiol, 263, E584

Wolfe, 2004

Bergstrom, 1974, Intracellular free amino acid concentration in human muscle tissue, J Appl Physiol, 36, 693, 10.1152/jappl.1974.36.6.693

Cuthbertson, 2005, Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle, FASEB J, 19, 422, 10.1096/fj.04-2640fje

Smith, 1998, Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein, Am J Physiol, 275, E73

Boirie, 1997, Slow and fast dietary proteins differently modulate postprandial protein accretion, Proc Natl Acad Sci U S A, 94, 14930, 10.1073/pnas.94.26.14930

Hayes, 2008, Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training, Curr Opin Clin Nutr Metab Care, 11, 40, 10.1097/MCO.0b013e3282f2a57d

Rocha, 1972, Glucagon-stimulating activity of 20 amino acids in dogs, J Clin Invest, 51, 2346, 10.1172/JCI107046

Volpi, 1998, Exogenous amino acids stimulate net muscle protein synthesis in the elderly, J Clin Invest, 101, 2000, 10.1172/JCI939

Schmidt, 1992, Insulin secretion from pancreatic B cells caused by l-arginine–derived nitrogen oxides, Science, 255, 721, 10.1126/science.1371193

Drucker, 2006, The biology of incretin hormones, Cell Metab, 3, 153, 10.1016/j.cmet.2006.01.004

Nilsson, 2004, Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins, Am J Clin Nutr, 80, 1246, 10.1093/ajcn/80.5.1246

Tessari, 2006, Slow versus fast proteins in the stimulation of beta-cell response and the activation of the entero-insular axis in type 2 diabetes, Diabetes Metab Res Rev, 23, 378, 10.1002/dmrr.698

Fujita, 2006, Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability, Am J Physiol Endocrinol Metab, 291, E745, 10.1152/ajpendo.00271.2005

Chow, 2006, Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures, Am J Physiol Endocrinol Metab, 291, E729, 10.1152/ajpendo.00003.2006

Volpi, 2000, The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly, J Clin Endocrinol Metab, 85, 4481, 10.1210/jc.85.12.4481

Guillet, 2004, Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects, J Clin Endocrinol Metab, 89, 6017, 10.1210/jc.2003-031323

Guillet, 2004, Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans, FASEB J, 18, 1586, 10.1096/fj.03-1341fje

Daenzer, 2001, Whole-body nitrogen and splanchnic amino acid metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture, J Nutr, 131, 1965, 10.1093/jn/131.7.1965

Trocki, 1986, Intact protein versus free amino acids in the nutritional support of thermally injured animals, JPEN J Parenter Enteral Nutr, 10, 139, 10.1177/0148607186010002139

Ha, 2003, Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review), J Nutr Biochem, 14, 251, 10.1016/S0955-2863(03)00030-5

Krissansen, 2007, Emerging health properties of whey proteins and their clinical implications, J Am Coll Nutr, 26, 713S, 10.1080/07315724.2007.10719652

Walzem, 2002, Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking, Crit Rev Food Sci Nutr, 42, 353, 10.1080/10408690290825574

Yalcin, 2006, Emerging therapeutic potential of whey proteins and peptides, Curr Pharm Des, 12, 1637, 10.2174/138161206776843296