Waterhouse-Friderichsen Syndrome Secondary to Capnocytophaga canimorsus Septicemia and Demonstration of Bacteremia by Peripheral Blood Smear

Archives of Pathology and Laboratory Medicine - Tập 124 Số 6 - Trang 859-863 - 2000
Imran Mirza1,2, John H. Wolk1, Lajos Barna Tóth1, Peter Rostenberg1, Ramon Kranwinkel1, Steven Sieber1
1From the Departments of Pathology and Laboratory Medicine (Drs Mirza, Wolk, Kranwinkel, and Sieber) and Medicine (Drs Rostenberg and Toth), Danbury Hospital, Danbury, Conn.
2Reprints: Imran Mirza, MD, MS, Department of Pathology and Laboratory Medicine, Danbury Hospital, 24 Hospital Ave, Danbury, CT 06810.

Tóm tắt

Abstract Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus septicemia was fatal in a previously healthy 47-year-old woman. The patient died suddenly in less than 12 hours after presentation, in spite of supportive measures, including ventilation, antibiotic coverage, pressor therapy, and multiple transfusions of blood products. The diagnosis of infection due to an unusual organism was suspected earlier in the course of management after review of the peripheral blood smear. The importance of the findings in the blood smear and their correlation with infection due to this organism are discussed.

Từ khóa


Tài liệu tham khảo

Kullberg, 1991, Purpura fulminans and symmetrical peripheral gangrene caused by Capnocytophaga canimorsus (formerly DF-2) septicemia: a complication of dog bite., Medicine, 70, 287, 10.1097/00005792-199109000-00001

Bobo, 1976, A previously undescribed gram-negative bacillus causing septicemia and meningitis., Am J Clin Pathol, 65, 564, 10.1093/ajcp/65.4.564

Brenner, 1989, Capnocytophaga canimorsus sp nov (formerly CDC group DF-2), a cause of septicemia following dog bite, and C cynodegmi sp nov, a cause of localized wound infection following dog bite., J Clin Microbiol, 27, 231, 10.1128/JCM.27.2.231-235.1989

Westwell, 1989, DF-2 infection., BMJ, 298, 116, 10.1136/bmj.298.6666.116-c

Parenti, 1985, Capnocytophaga species: infection in nonimmunocompromised and compromised hosts., J Infect Dis, 151, 140, 10.1093/infdis/151.1.140

Schlossberg, 1987, Septicemia caused by DF-2., J Clin Microbiol, 9, 884

Ndon, 1992, Capnocytophaga canimorsus septicemia caused by a dog bite in a hairy cell leukemia patient., J Clin Microbiol, 30, 211, 10.1128/JCM.30.1.211-213.1992

Roblot, 1993, Septicemia due to Capnocytophaga canimorsus after a dog bite in a cirrhotic patient., Eur J Clin Microbiol Infect Dis, 12, 302, 10.1007/BF01967265

Pres, 1996, Capnocytophaga canimorsus septicemia in Denmark, 1982–1995: review of 39 cases., Clin Infect Dis, 23, 71, 10.1093/clinids/23.1.71

Chaudhuri, 1981, Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient., J Clin Pathol, 34, 172, 10.1136/jcp.34.2.172

Martone, 1980, Postsplenectomy sepsis with DF-2: report of a case with isolation of the organism from the patient's dog., Ann Intern Med, 93, 457, 10.7326/0003-4819-93-3-457

Hicklin, 1987, Dysgonic fermenter-2 septicemia., Rev Infect Dis, 9, 884, 10.1093/clinids/9.5.884

Alberio, 1998, Images in clinical medicine. Capnocytophaga canimorsus sepsis., N Engl J Med, 339, 1827, 10.1056/NEJM199812173392506

Mossad, 1997, Diagnosis: Capnocytophaga canimorsus septicemia., Clin Infect Dis, 24, 123

Pedersen, 1993, Capnocytophaga canimorsus bacteremia demonstrated by a positive blood smear: a case report., APMIS, 101, 572, 10.1111/j.1699-0463.1993.tb00148.x

Shurin, 1979, A neutrophil disorder induced by Capnocytophaga, a dental microorganism., N Engl Med J, 301, 849, 10.1056/NEJM197910183011601

Fischer, 1995, Intracellular multiplication and toxic destruction of cultured macrophages by Capnocytophaga canimorsus., Infect Immun, 63, 3483, 10.1128/IAI.63.9.3484-3490.1995